Protein: NGAL
Neutrophil gelatinase-associated lipocalin (NGAL) (25 kDa alpha-2-microglobulin-related subunit of MMP-9) (Lipocalin-2) (Oncogene 24p3) (Siderocalin) (p25)

Gene: NGAL, LCN2
Organism: Homo sapiens
Interactions: 181
UniProt ID: P80188

Gene Ontology (top 5):
GO:0002020 - protease binding
GO:0005506 - iron ion binding
GO:0005576 - extracellular region
GO:0005615 - extracellular space
GO:0006953 - acute-phase response

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1009635

NGAL
Neutrophil gelatinase-associated lipocalin

3

5

Small-scale

0.843

High

1009722

CLMP
CXADR-like membrane protein

2

1

High-throughput

0.700

High

1009682

FNDC5
Fibronectin type III domain-containing protein 5

1

1

High-throughput

0.691

High

575784

MMP9
Matrix metalloproteinase-9

4

3

Small-scale

0.676

High

522647

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

0

High-throughput

0.656

High

585447

VEGFA
Vascular endothelial growth factor A, long form

1

0

High-throughput

0.630

High

1009749

DD19B
ATP-dependent RNA helicase DDX19B

2

2

High-throughput

0.611

High

1009650

KI3S1
Killer cell immunoglobulin-like receptor 3DS1

3

5

High-throughput

0.609

High

1009727

UD110
UDP-glucuronosyltransferase 1A10

3

1

High-throughput

0.609

High

666821

CCNC
Cyclin-C

3

1

High-throughput

0.607

High

452234

PDIA1
Protein disulfide-isomerase

2

1

High-throughput

0.606

High

566627

PDIA4
Protein disulfide-isomerase A4

2

1

High-throughput

0.606

High

930674

AAPK2
5'-AMP-activated protein kinase catalytic subunit alpha-2

2

1

High-throughput

0.606

High

943753

UBS3A
Ubiquitin-associated and SH3 domain-containing protein A

2

2

High-throughput

0.606

High

1009645

TRI32
E3 ubiquitin-protein ligase TRIM32

2

1

High-throughput

0.606

High

1009667

LAIR2
Leukocyte-associated immunoglobulin-like receptor 2

2

3

High-throughput

0.606

High

1009678

TBC21
TBC1 domain family member 21

2

1

High-throughput

0.606

High

1009744

LCAP
Leucyl-cystinyl aminopeptidase

2

1

High-throughput

0.606

High

1009750

UBQL1
Ubiquilin-1

2

4

High-throughput

0.606

High

376985

ANF
Natriuretic peptides A

2

0

High-throughput

0.602

High

260748

RAMP2
Receptor activity-modifying protein 2

2

0

High-throughput

0.580

High

631850

TRH
Pro-thyrotropin-releasing hormone

2

0

High-throughput

0.580

High

883084

AL7A1
Alpha-aminoadipic semialdehyde dehydrogenase

2

0

High-throughput

0.580

High

1009646

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

2

0

High-throughput

0.580

High

1009654

ODAPH
Odontogenesis associated phosphoprotein

2

0

High-throughput

0.580

High

1009690

MYDGF
Myeloid-derived growth factor

2

0

High-throughput

0.580

High

1009706

TS101
Tumor susceptibility gene 101 protein

2

0

High-throughput

0.580

High

1009755

LY96
Lymphocyte antigen 96

2

0

High-throughput

0.580

High

1009700

SNX27
Sorting nexin-27

2

1

High-throughput

0.574

High

1009724

DDX31
ATP-dependent DNA helicase DDX31

2

2

High-throughput

0.574

High

1009729

SHCAF
SIN3-HDAC complex-associated factor

2

1

High-throughput

0.574

High

1009647

ITA9
Integrin alpha-9

2

6

High-throughput

0.558

High

1009662

MYOME
Myomegalin

2

1

High-throughput

0.558

High

158564

CTDS2
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 2

2

1

High-throughput

0.553

High

226751

SGTA
Small glutamine-rich tetratricopeptide repeat-containing protein alpha

2

1

High-throughput

0.553

High

1009643

PO4F2
POU domain, class 4, transcription factor 2

2

1

High-throughput

0.553

High

1009648

VEZF1
Vascular endothelial zinc finger 1

2

1

High-throughput

0.553

High

1009676

MSRB3
Methionine-R-sulfoxide reductase B3

2

1

High-throughput

0.553

High

1009688

ASB10
Ankyrin repeat and SOCS box protein 10

2

1

High-throughput

0.553

High

1009691

UBE2F
NEDD8-conjugating enzyme UBE2F

2

1

High-throughput

0.553

High

1009697

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

2

1

High-throughput

0.553

High

1009705

THIOM
Thioredoxin, mitochondrial

2

2

High-throughput

0.553

High

1009741

UBQL2
Ubiquilin-2

2

4

High-throughput

0.553

High

132588

UPK1A
Uroplakin-1a

1

3

High-throughput

0.536

High

141997

FCN1
Ficolin-1

1

1

High-throughput

0.536

High

210742

KLK10
Kallikrein-10

1

1

High-throughput

0.536

High

222364

TSN6
Tetraspanin-6

1

1

High-throughput

0.536

High

1009687

ITLN2
Intelectin-2

1

1

High-throughput

0.536

High

1009708

EGFL8
Epidermal growth factor-like protein 8

1

4

High-throughput

0.536

High

1009716

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

2

High-throughput

0.536

High

46364

A0A1U9X8X8
Corneodesmosin

1

1

High-throughput

0.515

High

292613

RENR
Renin receptor

1

0

High-throughput

0.513

High

1009644

FSTL1
Follistatin-related protein 1

1

0

High-throughput

0.513

High

1009712

MMTA2
Multiple myeloma tumor-associated protein 2

1

0

High-throughput

0.513

High

1009726

COE2
Transcription factor COE2

1

0

High-throughput

0.513

High

1009728

CP343
Cytochrome P450 3A43

1

0

High-throughput

0.513

High

1009739

DKK2
Dickkopf-related protein 2

1

0

High-throughput

0.513

High

133855

FOXN3
Forkhead box protein N3

1

1

High-throughput

0.489

High

335239

CXB5
Gap junction beta-5 protein

1

2

High-throughput

0.489

High

352702

NUDT3
Diphosphoinositol polyphosphate phosphohydrolase 1

1

1

High-throughput

0.489

High

552200

ADT3
ADP/ATP translocase 3

1

5

High-throughput

0.489

High

622792

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

1

3

High-throughput

0.489

High

733329

CCR1
C-C chemokine receptor type 1

1

3

High-throughput

0.489

High

873854

PCP4
Calmodulin regulator protein PCP4

1

1

High-throughput

0.489

High

876314

PTSS1
Phosphatidylserine synthase 1

1

1

High-throughput

0.489

High

896685

ASCL1
Achaete-scute homolog 1

1

1

High-throughput

0.489

High

943463

DSCR6
Protein ripply3

1

1

High-throughput

0.489

High

1009640

GABPA
GA-binding protein alpha chain

1

3

High-throughput

0.489

High

1009652

ZIC1
Zinc finger protein ZIC 1

1

1

High-throughput

0.489

High

1009657

T176B
Transmembrane protein 176B

1

1

High-throughput

0.489

High

1009658

LRC10
Leucine-rich repeat-containing protein 10

1

2

High-throughput

0.489

High

1009663

UBE2U
Ubiquitin-conjugating enzyme E2 U

1

2

High-throughput

0.489

High

1009669

SFXN4
Sideroflexin-4

1

1

High-throughput

0.489

High

1009671

APTX
Aprataxin

1

1

High-throughput

0.489

High

1009683

NFAM1
NFAT activation molecule 1

1

1

High-throughput

0.489

High

1009684

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

3

High-throughput

0.489

High

1009685

RHBL4
Rhomboid-related protein 4

1

2

High-throughput

0.489

High

1009693

SIA7F
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6

1

3

High-throughput

0.489

High

1009695

SARAF
Store-operated calcium entry-associated regulatory factor

1

1

High-throughput

0.489

High

1009702

FMNL2
Formin-like protein 2

1

2

High-throughput

0.489

High

1009703

TEFM
Transcription elongation factor, mitochondrial

1

1

High-throughput

0.489

High

1009707

PLCA
1-acyl-sn-glycerol-3-phosphate acyltransferase alpha

1

1

High-throughput

0.489

High

1009710

SH23A
SH2 domain-containing protein 3A

1

6

High-throughput

0.489

High

1009730

ST7
Suppressor of tumorigenicity 7 protein

1

1

High-throughput

0.489

High

1009733

KLH11
Kelch-like protein 11

1

2

High-throughput

0.489

High

1009734

GID8
Glucose-induced degradation protein 8 homolog

1

2

High-throughput

0.489

High

1009752

RN115
E3 ubiquitin-protein ligase RNF115

1

1

High-throughput

0.489

High

1009753

NPTN
Neuroplastin

1

1

High-throughput

0.489

High

1009651

CDSN
Corneodesmosin

1

1

High-throughput

0.481

High

469671

MMP2
72 kDa type IV collagenase

1

3

Small-scale

0.479

High

606615

CEBPB
CCAAT/enhancer-binding protein beta

1

1

Small-scale

0.479

High

626175

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

4

Small-scale

0.479

High

1009636

LRP2
Low-density lipoprotein receptor-related protein 2

1

2

Small-scale

0.479

High

1009638

TF65
Transcription factor p65

1

3

Small-scale

0.479

High

1009680

TOR2X
Prosalusin

1

2

High-throughput

0.479

High

1009718

IKBZ
NF-kappa-B inhibitor zeta

1

4

Small-scale

0.479

High

75153

FM25C
Protein FAM25C

1

3

High-throughput

0.470

High

1009754

Q9Y6T4
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

1

1

High-throughput

0.470

High

485059

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

0

High-throughput

0.458

High

1009686

S22AH
Solute carrier family 22 member 17

1

0

Small-scale

0.458

High

1009639

UBE3A
Ubiquitin-protein ligase E3A

1

1

Small-scale

0.457

High

1009649

RFTN1
Raftlin

1

1

High-throughput

0.445

High

1009653

NF2L2
Nuclear factor erythroid 2-related factor 2

1

2

High-throughput

0.445

High

75134

FM25A
Protein FAM25A

1

3

High-throughput

0.439

High

328463

NDUB2
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 2, mitochondrial

1

1

High-throughput

0.439

High

302478

RNF8
E3 ubiquitin-protein ligase RNF8

1

3

High-throughput

0.437

High

1009673

UBP48
Ubiquitin carboxyl-terminal hydrolase 48

1

2

Small-scale

0.437

High

1009689

ESR2
Estrogen receptor beta

1

3

High-throughput

0.437

High

1009721

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.437

High

1009737

UBP36
Ubiquitin carboxyl-terminal hydrolase 36

1

1

High-throughput

0.437

High

406968

THY1
Thy-1 membrane glycoprotein

1

0

High-throughput

0.426

High

536958

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.426

High

770149

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.426

High

96896

E9PDS3
Integrin subunit alpha 9

1

6

High-throughput

0.407

High

943909

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.407

High

1009660

TOR2A
Torsin-2A

1

2

High-throughput

0.407

High

1009665

A16L1
Autophagy-related protein 16-1

1

2

High-throughput

0.407

High

1009696

ASB9
Ankyrin repeat and SOCS box protein 9

1

2

High-throughput

0.407

High

1009745

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

5

High-throughput

0.407

High

1009725

L2HDH
L-2-hydroxyglutarate dehydrogenase, mitochondrial

3

0

High-throughput

0.347

High

1009732

TB22B
TBC1 domain family member 22B

2

0

High-throughput

0.328

High

225163

TRIA1
TP53-regulated inhibitor of apoptosis 1

2

0

High-throughput

0.316

High

354218

ZBED1
E3 SUMO-protein ligase ZBED1

2

0

High-throughput

0.316

High

878653

CAMLG
Guided entry of tail-anchored proteins factor CAMLG

2

0

High-throughput

0.316

High

949000

SC61G
Protein transport protein Sec61 subunit gamma

2

0

High-throughput

0.316

High

1009642

ASPH
Aspartyl/asparaginyl beta-hydroxylase

2

0

High-throughput

0.316

High

1009664

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1009668

FAP20
Fanconi anemia core complex-associated protein 20

2

0

High-throughput

0.316

High

1009672

HDDC2
5'-deoxynucleotidase HDDC2

2

0

High-throughput

0.316

High

1009674

PTH
Peptidyl-tRNA hydrolase

2

0

High-throughput

0.316

High

1009692

NEIL2
Endonuclease 8-like 2

2

0

High-throughput

0.316

High

1009698

PELI1
E3 ubiquitin-protein ligase pellino homolog 1

2

0

High-throughput

0.316

High

1009699

MAGD4
Melanoma-associated antigen D4

2

0

High-throughput

0.316

High

1009701

BMF
Bcl-2-modifying factor

2

0

High-throughput

0.316

High

1009714

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.316

High

1009717

BEX2
Protein BEX2

2

0

High-throughput

0.316

High

1009719

XRN2
5'-3' exoribonuclease 2

2

0

High-throughput

0.316

High

1009720

CMIP1
Ciliary microtubule inner protein 1

2

0

High-throughput

0.316

High

1009731

PICK1
PRKCA-binding protein

2

0

High-throughput

0.316

High

1009735

ALKB4
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4

2

0

High-throughput

0.316

High

1009740

DPOLL
DNA polymerase lambda

2

0

High-throughput

0.316

High

1009747

CHIC2
Cysteine-rich hydrophobic domain-containing protein 2

2

0

High-throughput

0.316

High

1009748

TPC2L
Trafficking protein particle complex subunit 2-like protein

2

0

High-throughput

0.316

High

210185

IRAK2
Interleukin-1 receptor-associated kinase-like 2

1

0

High-throughput

0.279

Low

229226

G6PT1
Glucose-6-phosphate exchanger SLC37A4

1

0

High-throughput

0.279

Low

254962

HCN1
Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

1

0

High-throughput

0.279

Low

325312

OR2A4
Olfactory receptor 2A4

1

0

High-throughput

0.279

Low

327220

ZFPL1
Zinc finger protein-like 1

1

0

High-throughput

0.279

Low

331660

MBD4
Methyl-CpG-binding domain protein 4

1

0

High-throughput

0.279

Low

929318

OAZ1
Ornithine decarboxylase antizyme 1

1

0

High-throughput

0.279

Low

943035

STX17
Syntaxin-17

1

0

High-throughput

0.279

Low

967254

TIM10
Mitochondrial import inner membrane translocase subunit Tim10

1

0

High-throughput

0.279

Low

1009637

2ABB
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform

1

0

High-throughput

0.279

Low

1009655

INSC
Protein inscuteable homolog

1

0

High-throughput

0.279

Low

1009656

CR021
UPF0711 protein C18orf21

1

0

High-throughput

0.279

Low

1009659

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.279

Low

1009670

DPPA3
Developmental pluripotency-associated protein 3

1

0

High-throughput

0.279

Low

1009675

CERS3
Ceramide synthase 3

1

0

High-throughput

0.279

Low

1009677

ELOA2
Elongin-A2

1

0

High-throughput

0.279

Low

1009679

NRSN1
Neurensin-1

1

0

High-throughput

0.279

Low

1009681

IQUB
IQ motif and ubiquitin-like domain-containing protein

1

0

High-throughput

0.279

Low

1009694

RNF25
E3 ubiquitin-protein ligase RNF25

1

0

High-throughput

0.279

Low

1009709

TREX2
Three prime repair exonuclease 2

1

0

High-throughput

0.279

Low

1009715

5NT1A
Cytosolic 5'-nucleotidase 1A

1

0

High-throughput

0.279

Low

1009723

ZDHC6
Palmitoyltransferase ZDHHC6

1

0

High-throughput

0.279

Low

1009738

THA10
THAP domain-containing protein 10

1

0

High-throughput

0.279

Low

1009742

SMBT1
Scm-like with four MBT domains protein 1

1

0

High-throughput

0.279

Low

1009743

PHF11
PHD finger protein 11

1

0

High-throughput

0.279

Low

1009746

GBG8
Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-8

1

0

High-throughput

0.279

Low

1009751

SSUH2
Protein SSUH2 homolog

1

0

High-throughput

0.279

Low

1009641

ECHP
Peroxisomal bifunctional enzyme

1

0

High-throughput

0.268

Low

1009661

LCE3A
Late cornified envelope protein 3A

1

0

High-throughput

0.268

Low

1009711

URM1
Ubiquitin-related modifier 1

1

0

Small-scale

0.261

Low

1009736

TBA8
Tubulin alpha-8 chain

1

0

High-throughput

0.251

Low

71202

HIDE1
Protein HIDE1

1

0

High-throughput

0.232

Low

261149

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.232

Low

665565

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

1

0

High-throughput

0.232

Low

1009666

RL7L
Ribosomal protein uL30-like

1

0

High-throughput

0.232

Low

1009704

MYCBP
c-Myc-binding protein

1

0

High-throughput

0.232

Low

1009713

RSRP1
Arginine/serine-rich protein 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025