Protein: T2EA
General transcription factor IIE subunit 1 (General transcription factor IIE 56 kDa subunit) (Transcription initiation factor IIE subunit alpha) (TFIIE-alpha)

Gene: T2EA, GTF2E1
Organism: Homo sapiens
Interactions: 73
UniProt ID: P29083

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005669 - transcription factor TFIID complex
GO:0005673 - transcription factor TFIIE complex
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

708874

T2EB
Transcription initiation factor IIE subunit beta

12

6

Small-scale

0.982

High

708876

TF2H1
General transcription factor IIH subunit 1

5

2

Small-scale

0.933

High

667180

RPB1
DNA-directed RNA polymerase II subunit RPB1

2

1

Small-scale

0.806

High

708890

TF2B
Transcription initiation factor IIB

2

1

Small-scale

0.806

High

708877

T2FA
General transcription factor IIF subunit 1

4

1

Small-scale

0.694

High

708882

CDK7
Cyclin-dependent kinase 7

4

1

Small-scale

0.686

High

628708

TBP
TATA-box-binding protein

3

0

Small-scale

0.639

High

708922

NEMO
NF-kappa-B essential modulator

2

0

High-throughput

0.606

High

569061

T2FB
General transcription factor IIF subunit 2

2

1

Small-scale

0.602

High

622762

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

2

2

Small-scale

0.602

High

708887

H31
Histone H3.1

2

1

High-throughput

0.584

High

708881

TAF6
Transcription initiation factor TFIID subunit 6

2

0

Small-scale

0.577

High

654618

TCEA1
Transcription elongation factor A protein 1

2

0

Small-scale

0.560

High

708911

TF2H4
General transcription factor IIH subunit 4

1

1

Small-scale

0.550

High

708912

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

2

High-throughput

0.541

High

167828

IKKB
Inhibitor of nuclear factor kappa-B kinase subunit beta

1

1

High-throughput

0.536

High

177802

IKKA
Inhibitor of nuclear factor kappa-B kinase subunit alpha

1

1

High-throughput

0.536

High

708888

SRPK2
SRSF protein kinase 2

1

0

High-throughput

0.527

High

708900

TAF11
Transcription initiation factor TFIID subunit 11

1

0

Small-scale

0.527

High

216165

MTG8R
Protein CBFA2T2

1

0

High-throughput

0.518

High

708898

TRI29
Tripartite motif-containing protein 29

1

0

High-throughput

0.518

High

708910

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.518

High

708914

TRI15
E3 ubiquitin-protein ligase TRIM15

1

0

High-throughput

0.518

High

708894

MED21
Mediator of RNA polymerase II transcription subunit 21

1

0

Small-scale

0.513

High

708917

MED17
Mediator of RNA polymerase II transcription subunit 17

1

0

High-throughput

0.513

High

180714

TIF1A
Transcription intermediary factor 1-alpha

1

2

Small-scale

0.501

High

185448

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

611645

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

1

1

Small-scale

0.501

High

708896

TF2H2
General transcription factor IIH subunit 2

1

1

Small-scale

0.501

High

708897

TF2H3
General transcription factor IIH subunit 3

1

1

Small-scale

0.501

High

421551

A4
Amyloid-beta precursor protein

1

0

High-throughput

0.480

High

639672

TAF1
Transcription initiation factor TFIID subunit 1

1

0

Small-scale

0.480

High

708883

TF2AA
Transcription initiation factor IIA subunit 1

1

0

Small-scale

0.480

High

708892

TLE5
TLE family member 5

1

0

Small-scale

0.480

High

708904

TF2H5
General transcription factor IIH subunit 5

1

0

Small-scale

0.480

High

708905

SND1
Staphylococcal nuclease domain-containing protein 1

1

0

Small-scale

0.480

High

254333

CC14B
Dual specificity protein phosphatase CDC14B

1

1

High-throughput

0.479

High

708875

PML
Protein PML

1

2

High-throughput

0.479

High

708880

CDK8
Cyclin-dependent kinase 8

1

1

High-throughput

0.479

High

708889

H33
Histone H3.3

1

1

High-throughput

0.479

High

708913

DDX23
Probable ATP-dependent RNA helicase DDX23

1

1

High-throughput

0.479

High

190828

RPA34
DNA-directed RNA polymerase I subunit RPA34

1

0

High-throughput

0.458

High

259491

BRD4
Bromodomain-containing protein 4

1

0

High-throughput

0.458

High

331546

KIF4A
Chromosome-associated kinesin KIF4A

1

0

High-throughput

0.458

High

385478

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

469260

ASNS
Asparagine synthetase [glutamine-hydrolyzing]

1

0

Small-scale

0.458

High

486989

PARP1
Poly [ADP-ribose] polymerase 1

1

0

High-throughput

0.458

High

557883

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.458

High

674945

TNR6
Tumor necrosis factor receptor superfamily member 6

1

0

High-throughput

0.458

High

708879

COIL
Coilin

1

0

High-throughput

0.458

High

708885

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

0

High-throughput

0.458

High

708886

ACTC
Actin, alpha cardiac muscle 1

1

0

High-throughput

0.458

High

708891

EWS
RNA-binding protein EWS

1

0

High-throughput

0.458

High

708893

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

708895

CUL3
Cullin-3

1

0

High-throughput

0.458

High

708899

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

708902

MCAF1
Activating transcription factor 7-interacting protein 1

1

0

Small-scale

0.458

High

708903

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

708907

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

708915

RPA49
DNA-directed RNA polymerase I subunit RPA49

1

0

High-throughput

0.458

High

708918

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

708919

NUP50
Nuclear pore complex protein Nup50

1

0

High-throughput

0.458

High

708921

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

708920

S45A2
Membrane-associated transporter protein

1

1

High-throughput

0.437

High

708878

BRCA1
Breast cancer type 1 susceptibility protein

1

0

Small-scale

0.426

High

708901

ELP2
Elongator complex protein 2

1

0

High-throughput

0.426

High

708908

TF2LY
Homeobox protein TGIF2LY

1

0

High-throughput

0.426

High

94488

D6RGY6
Solute carrier family 45 member 2

1

1

High-throughput

0.407

High

708906

NRARP
Notch-regulated ankyrin repeat-containing protein

2

0

High-throughput

0.316

High

708909

TBC21
TBC1 domain family member 21

2

0

High-throughput

0.316

High

708916

PHS2
Pterin-4-alpha-carbinolamine dehydratase 2

1

0

High-throughput

0.282

High

708884

FCGRN
IgG receptor FcRn large subunit p51

1

0

High-throughput

0.279

Low

566919

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025