Protein: DHYS
Deoxyhypusine synthase (DHS) (EC 2.5.1.46)

Gene: DHYS, DHPS
Organism: Homo sapiens
Interactions: 85
UniProt ID: P49366

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006412 - translation
GO:0008216 - spermidine metabolic process
GO:0008284 - positive regulation of cell population proliferation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

691675

MK03
Mitogen-activated protein kinase 3

10

3

High-throughput

0.977

High

881807

IF5A2
Eukaryotic translation initiation factor 5A-2

5

7

High-throughput

0.937

High

703495

MK01
Mitogen-activated protein kinase 1

5

3

High-throughput

0.908

High

881763

IF5A1
Eukaryotic translation initiation factor 5A-1

3

7

High-throughput

0.871

High

881754

DHYS
Deoxyhypusine synthase

3

3

High-throughput

0.861

High

881764

CDK17
Cyclin-dependent kinase 17

2

1

High-throughput

0.789

High

748960

RL9
Large ribosomal subunit protein uL6

6

0

High-throughput

0.710

High

881767

REL
Proto-oncogene c-Rel

3

0

High-throughput

0.646

High

881759

TIRAP
Toll/interleukin-1 receptor domain-containing adapter protein

3

0

High-throughput

0.638

High

881770

BYST
Bystin

3

0

High-throughput

0.638

High

881785

NUD18
8-oxo-dGDP phosphatase NUDT18

2

0

High-throughput

0.613

High

881806

NIF3L
NIF3-like protein 1

2

0

High-throughput

0.613

High

216304

KCAB3
Voltage-gated potassium channel subunit beta-3

2

1

High-throughput

0.611

High

767040

PTN7
Tyrosine-protein phosphatase non-receptor type 7

2

2

High-throughput

0.611

High

881775

PTPRR
Receptor-type tyrosine-protein phosphatase R

2

1

High-throughput

0.611

High

655107

SFPQ
Splicing factor, proline- and glutamine-rich

2

0

High-throughput

0.602

High

881771

SAFB2
Scaffold attachment factor B2

2

0

High-throughput

0.602

High

881777

RHG15
Rho GTPase-activating protein 15

2

0

High-throughput

0.585

High

881812

SPHK1
Sphingosine kinase 1

2

0

High-throughput

0.585

High

482145

RET1
Retinol-binding protein 1

2

0

High-throughput

0.580

High

685125

PAX6
Paired box protein Pax-6

2

0

High-throughput

0.580

High

881797

LNX1
E3 ubiquitin-protein ligase LNX

2

0

High-throughput

0.580

High

881799

ES8L1
Epidermal growth factor receptor kinase substrate 8-like protein 1

2

0

High-throughput

0.576

High

798840

BRCA1
Breast cancer type 1 susceptibility protein

2

0

High-throughput

0.561

High

881787

VASH1
Tubulinyl-Tyr carboxypeptidase 1

1

0

High-throughput

0.549

High

881804

NTAQ1
Protein N-terminal glutamine amidohydrolase

1

0

High-throughput

0.549

High

881757

DRG2
Developmentally-regulated GTP-binding protein 2

2

0

High-throughput

0.547

High

881792

DAA11
Dynein axonemal assembly factor 11

1

1

High-throughput

0.536

High

194812

KCNN4
Intermediate conductance calcium-activated potassium channel protein 4

1

0

High-throughput

0.513

High

664035

PRTN3
Myeloblastin

1

0

High-throughput

0.513

High

881758

DLX1
Homeobox protein DLX-1

1

0

High-throughput

0.513

High

881765

SRSF2
Serine/arginine-rich splicing factor 2

1

0

High-throughput

0.513

High

881783

PADI6
Inactive protein-arginine deiminase type-6

1

0

High-throughput

0.513

High

881790

SPA24
Spermatogenesis-associated protein 24

1

0

High-throughput

0.513

High

881794

PLCD3
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-3

1

0

High-throughput

0.513

High

881798

CCHCR
Coiled-coil alpha-helical rod protein 1

1

0

High-throughput

0.513

High

881801

CSN9
COP9 signalosome complex subunit 9

1

0

High-throughput

0.513

High

881762

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.493

High

881810

PTPRH
Receptor-type tyrosine-protein phosphatase H

1

0

High-throughput

0.493

High

881755

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

58710

PTPC1
Protein tyrosine phosphatase domain-containing protein 1

1

2

High-throughput

0.479

High

881774

EXOS7
Exosome complex component RRP42

1

1

High-throughput

0.479

High

881800

DUS19
Dual specificity protein phosphatase 19

1

1

High-throughput

0.479

High

881808

PTN23
Tyrosine-protein phosphatase non-receptor type 23

1

1

Small-scale

0.479

High

881811

EXOS4
Exosome complex component RRP41

1

1

High-throughput

0.479

High

881816

ANC2
Anaphase-promoting complex subunit 2

1

1

High-throughput

0.479

High

881781

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.470

High

315275

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

376758

TGFB1
Transforming growth factor beta-1 proprotein [Cleaved into: Latency-associated peptide

1

0

High-throughput

0.458

High

606417

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

881760

ARP3
Actin-related protein 3

1

0

High-throughput

0.458

High

881768

CUL3
Cullin-3

1

0

High-throughput

0.458

High

881769

EXOS2
Exosome complex component RRP4

1

0

High-throughput

0.458

High

881772

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

0

Small-scale

0.458

High

881773

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

881780

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.458

High

881784

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

881789

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

881802

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

881814

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

881815

XPO7
Exportin-7

1

0

High-throughput

0.458

High

881761

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.457

High

881776

DUS28
Dual specificity phosphatase 28

1

1

High-throughput

0.437

High

881782

PKHA7
Pleckstrin homology domain-containing family A member 7

1

0

High-throughput

0.426

High

125989

RB27B
Ras-related protein Rab-27B

3

0

High-throughput

0.352

High

881756

ZN138
Zinc finger protein 138

3

0

High-throughput

0.352

High

881779

SUSD4
Sushi domain-containing protein 4

3

0

High-throughput

0.347

High

881788

TAFA3
Chemokine-like protein TAFA-3

2

0

High-throughput

0.328

High

881805

ZN414
Zinc finger protein 414

2

0

High-throughput

0.328

High

881793

CFA46
Cilia- and flagella-associated protein 46

2

0

High-throughput

0.313

High

60638

CI170
Uncharacterized protein encoded by LINC02872

1

0

High-throughput

0.279

Low

282963

LGR5
Leucine-rich repeat-containing G-protein coupled receptor 5

1

0

High-throughput

0.279

Low

881778

SPXN4
Sperm protein associated with the nucleus on the X chromosome N4

1

0

High-throughput

0.279

Low

881791

PRSR2
Proline and serine-rich protein 2

1

0

High-throughput

0.279

Low

881795

ZN276
Zinc finger protein 276

1

0

High-throughput

0.279

Low

881796

F133A
Protein FAM133A

1

0

High-throughput

0.279

Low

881813

NHSL3
NHS-like protein 3

1

0

High-throughput

0.279

Low

279306

TULP3
Tubby-related protein 3

1

0

High-throughput

0.249

Low

881766

TLE3
Transducin-like enhancer protein 3

1

0

High-throughput

0.249

Low

881786

ASXL2
Putative Polycomb group protein ASXL2

1

0

High-throughput

0.249

Low

881803

VP33A
Vacuolar protein sorting-associated protein 33A

1

0

High-throughput

0.249

Low

881809

SP110
Sp110 nuclear body protein

1

0

High-throughput

0.249

Low

881817

SRRM2
Serine/arginine repetitive matrix protein 2

1

0

High-throughput

0.249

Low

2095

TVA20
T cell receptor alpha variable 20

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025