Protein: TPM2
Tropomyosin beta chain (Beta-tropomyosin) (Tropomyosin-2)

Gene: TPM2
Organism: Homo sapiens
Interactions: 150
UniProt ID: P07951

Gene Ontology (top 5):
GO:0003779 - actin binding
GO:0005829 - cytosol
GO:0005862 - muscle thin filament tropomyosin
GO:0005884 - actin filament
GO:0006936 - muscle contraction

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

434329

TPM1
Tropomyosin alpha-1 chain

6

16

Small-scale

0.947

High

434327

TPM2
Tropomyosin beta chain

4

16

Small-scale

0.887

High

418845

TPM3
Tropomyosin alpha-3 chain

3

16

High-throughput

0.847

High

434370

TPM4
Tropomyosin alpha-4 chain

3

16

High-throughput

0.847

High

434354

MYH9
Myosin-9

1

6

High-throughput

0.691

High

434421

MYO19
Unconventional myosin-XIX

1

9

High-throughput

0.691

High

310889

SNAPN
SNARE-associated protein Snapin

3

5

High-throughput

0.667

High

434371

ACTS
Actin, alpha skeletal muscle

1

10

Small-scale

0.647

High

434438

PDLI7
PDZ and LIM domain protein 7

2

11

Small-scale

0.639

High

434415

MY18A
Unconventional myosin-XVIIIa

1

13

High-throughput

0.618

High

434437

MYO5C
Unconventional myosin-Vc

1

1

High-throughput

0.618

High

434358

MAGAA
Melanoma-associated antigen 10

2

3

High-throughput

0.611

High

434330

TFPT
TCF3 fusion partner

2

5

High-throughput

0.606

High

434441

ABI2
Abl interactor 2

2

3

High-throughput

0.606

High

434334

CFTR
Cystic fibrosis transmembrane conductance regulator

2

3

High-throughput

0.601

High

434385

CD5R1
Cyclin-dependent kinase 5 activator 1

2

0

High-throughput

0.585

High

434436

ANLN
Anillin

2

4

High-throughput

0.584

High

434364

RAD
GTP-binding protein RAD

1

5

Small-scale

0.561

High

66638

ZN785
Zinc finger protein 785

2

1

High-throughput

0.553

High

434397

ZN620
Zinc finger protein 620

2

1

High-throughput

0.553

High

213883

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

17

High-throughput

0.536

High

262220

ULK1
Serine/threonine-protein kinase ULK1

1

9

High-throughput

0.536

High

295787

ST17B
Serine/threonine-protein kinase 17B

1

11

High-throughput

0.536

High

434340

FLNA
Filamin-A

1

6

High-throughput

0.536

High

434344

CDK2
Cyclin-dependent kinase 2

1

7

High-throughput

0.536

High

434349

AKT1
RAC-alpha serine/threonine-protein kinase

1

7

Small-scale

0.536

High

434350

AKT2
RAC-beta serine/threonine-protein kinase

1

7

High-throughput

0.536

High

434351

BMI1
Polycomb complex protein BMI-1

1

9

High-throughput

0.536

High

434355

ADDA
Alpha-adducin

1

4

High-throughput

0.536

High

434374

MECOM
Histone-lysine N-methyltransferase MECOM

1

1

High-throughput

0.536

High

434392

LEG9C
Galectin-9C

1

6

High-throughput

0.536

High

434403

PIM3
Serine/threonine-protein kinase pim-3

1

11

High-throughput

0.536

High

434408

SYNPO
Synaptopodin

1

4

High-throughput

0.536

High

434409

ABTB2
Ankyrin repeat and BTB/POZ domain-containing protein 2

1

3

High-throughput

0.536

High

434425

AKAP9
A-kinase anchor protein 9

1

15

High-throughput

0.536

High

434429

RHBT2
Rho-related BTB domain-containing protein 2

1

10

High-throughput

0.536

High

434439

DISC1
Disrupted in schizophrenia 1 protein

1

4

High-throughput

0.536

High

434444

AAKG2
5'-AMP-activated protein kinase subunit gamma-2

1

3

High-throughput

0.536

High

434446

HSPB8
Heat shock protein beta-8

1

6

High-throughput

0.536

High

434347

CALR
Calreticulin

1

5

High-throughput

0.515

High

434410

ATAD1
Outer mitochondrial transmembrane helix translocase

1

8

High-throughput

0.515

High

434422

PDLI5
PDZ and LIM domain protein 5

1

11

High-throughput

0.515

High

434449

NINL
Ninein-like protein

1

9

High-throughput

0.515

High

336316

SODC
Superoxide dismutase [Cu-Zn]

1

1

High-throughput

0.515

High

434345

MK03
Mitogen-activated protein kinase 3

1

0

High-throughput

0.513

High

434382

SEPT2
Septin-2

1

0

High-throughput

0.513

High

434399

STOX1
Storkhead-box protein 1

1

0

High-throughput

0.513

High

434400

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.513

High

434413

POF1B
Protein POF1B

1

0

High-throughput

0.513

High

434339

NEBU
Nebulin

1

2

Small-scale

0.501

High

434394

MAST2
Microtubule-associated serine/threonine-protein kinase 2

1

10

High-throughput

0.494

High

434389

CBPC2
Cytosolic carboxypeptidase 2

1

0

High-throughput

0.493

High

434428

CA043
Protein C1orf43

1

0

High-throughput

0.493

High

434341

H1T
Histone H1t

1

3

High-throughput

0.489

High

434352

PCGF2
Polycomb group RING finger protein 2

1

6

High-throughput

0.489

High

434373

FHR3
Complement factor H-related protein 3

1

2

High-throughput

0.489

High

434375

SUH
Recombining binding protein suppressor of hairless

1

1

High-throughput

0.489

High

434386

CF184
Cilia- and flagella-associated protein 184

1

2

High-throughput

0.489

High

434405

FAM9C
Protein FAM9C

1

5

High-throughput

0.489

High

434406

SYCE1
Synaptonemal complex central element protein 1

1

3

High-throughput

0.489

High

434412

POC1B
POC1 centriolar protein homolog B

1

4

High-throughput

0.489

High

434427

WAC
WW domain-containing adapter protein with coiled-coil

1

2

High-throughput

0.489

High

168711

ARC1B
Actin-related protein 2/3 complex subunit 1B

1

1

Small-scale

0.479

High

301555

TRI37
E3 ubiquitin-protein ligase TRIM37

1

14

High-throughput

0.479

High

373545

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

6

High-throughput

0.479

High

397728

ISG15
Ubiquitin-like protein ISG15

1

7

High-throughput

0.479

High

434328

SP1
Transcription factor Sp1

1

7

Small-scale

0.479

High

434332

EPB41
Protein 4.1

1

1

High-throughput

0.479

High

434342

CRCM
Colorectal mutant cancer protein

1

8

High-throughput

0.479

High

434348

PSB9
Proteasome subunit beta type-9

1

3

High-throughput

0.479

High

434359

YAP1
Transcriptional coactivator YAP1

1

5

High-throughput

0.479

High

434360

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

5

High-throughput

0.479

High

434361

CAZA2
F-actin-capping protein subunit alpha-2

1

5

High-throughput

0.479

High

434366

PP1B
Serine/threonine-protein phosphatase PP1-beta catalytic subunit

1

8

High-throughput

0.479

High

434376

TFCP2
Alpha-globin transcription factor CP2

1

1

High-throughput

0.479

High

434377

G3BP1
Ras GTPase-activating protein-binding protein 1

1

2

High-throughput

0.479

High

434379

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

15

High-throughput

0.479

High

434380

SCRB2
Lysosome membrane protein 2

1

4

High-throughput

0.479

High

434383

TNIP1
TNFAIP3-interacting protein 1

1

15

High-throughput

0.479

High

434384

KIF14
Kinesin-like protein KIF14

1

6

High-throughput

0.479

High

434387

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

7

Small-scale

0.479

High

434390

RN213
E3 ubiquitin-protein ligase RNF213

1

1

High-throughput

0.479

High

434391

VIR
Protein virilizer homolog

1

1

High-throughput

0.479

High

434416

FBXW7
F-box/WD repeat-containing protein 7

1

2

High-throughput

0.479

High

434420

AURKB
Aurora kinase B

1

9

High-throughput

0.479

High

434434

ECT2
Protein ECT2

1

3

High-throughput

0.479

High

434442

HDAC6
Histone deacetylase 6

1

6

High-throughput

0.479

High

434443

ZRAN1
Ubiquitin thioesterase ZRANB1

1

6

High-throughput

0.479

High

434343

COF1
Cofilin-1

1

0

High-throughput

0.458

High

434365

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.458

High

434367

RS14
Small ribosomal subunit protein uS11

1

0

High-throughput

0.458

High

434368

RS28
Small ribosomal subunit protein eS28

1

0

High-throughput

0.458

High

434378

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

434404

SIR2
NAD-dependent protein deacetylase sirtuin-2

1

0

Small-scale

0.458

High

434331

TAU
Microtubule-associated protein tau

1

5

High-throughput

0.445

High

434369

GRB2
Growth factor receptor-bound protein 2

1

3

High-throughput

0.445

High

434423

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

5

High-throughput

0.445

High

129649

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

3

High-throughput

0.437

High

181040

INSI1
Insulin-induced gene 1 protein

1

5

High-throughput

0.437

High

308331

KI20A
Kinesin-like protein KIF20A

1

9

High-throughput

0.437

High

345722

MYC
Myc proto-oncogene protein

1

6

High-throughput

0.437

High

352448

TNFA
Tumor necrosis factor

1

9

High-throughput

0.437

High

378921

MYCN
N-myc proto-oncogene protein

1

6

High-throughput

0.437

High

390663

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

2

High-throughput

0.437

High

434357

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

3

High-throughput

0.437

High

434362

CDK9
Cyclin-dependent kinase 9

1

9

High-throughput

0.437

High

434363

GEM
GTP-binding protein GEM

1

5

High-throughput

0.437

High

434393

TET2
Methylcytosine dioxygenase TET2

1

2

Small-scale

0.437

High

434419

VMP1
Vacuole membrane protein 1

1

9

High-throughput

0.437

High

434430

DDX24
ATP-dependent RNA helicase DDX24

1

3

High-throughput

0.437

High

434431

SIK2
Serine/threonine-protein kinase SIK2

1

4

Small-scale

0.437

High

434433

PKHA4
Pleckstrin homology domain-containing family A member 4

1

7

High-throughput

0.437

High

434440

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

3

High-throughput

0.437

High

434447

PRP19
Pre-mRNA-processing factor 19

1

4

Small-scale

0.437

High

48858

POTB3
POTE ankyrin domain family member B3

1

1

High-throughput

0.407

High

434424

EBP2
Probable rRNA-processing protein EBP2

3

0

High-throughput

0.347

High

434398

S2548
Solute carrier family 25 member 48

2

0

High-throughput

0.328

High

434336

ZN250
Zinc finger protein 250

2

0

High-throughput

0.318

High

434407

CIART
Circadian-associated transcriptional repressor

2

0

High-throughput

0.318

High

434426

CF300
Cilia- and flagella-associated protein 300

2

0

High-throughput

0.318

High

311880

SYFM
Phenylalanine--tRNA ligase, mitochondrial

2

0

High-throughput

0.316

High

434381

MESD
LRP chaperone MESD

2

0

High-throughput

0.316

High

434445

ZN229
Zinc finger protein 229

2

0

High-throughput

0.316

High

434451

MOFA1
MORF4 family-associated protein 1

2

0

High-throughput

0.316

High

61989

ASPDH
Aspartate dehydrogenase domain-containing protein

2

0

High-throughput

0.313

High

70848

CF97D
Sperm axonemal maintenance protein CFAP97D1

1

0

High-throughput

0.279

Low

208506

TIM44
Mitochondrial import inner membrane translocase subunit TIM44

1

0

High-throughput

0.279

Low

434338

ZNF22
Zinc finger protein 22

1

0

High-throughput

0.279

Low

434395

TM205
Transmembrane protein 205

1

0

High-throughput

0.279

Low

434396

ZN704
Zinc finger protein 704

1

0

High-throughput

0.279

Low

434401

KANL1
KAT8 regulatory NSL complex subunit 1

1

0

High-throughput

0.279

Low

434402

GOGA7
Golgin subfamily A member 7

1

0

High-throughput

0.279

Low

434414

SCG3
Secretogranin-3

1

0

High-throughput

0.279

Low

434417

MITOK
Mitochondrial potassium channel

1

0

High-throughput

0.279

Low

434432

RSH6A
Radial spoke head protein 6 homolog A

1

0

High-throughput

0.279

Low

434435

SHCAF
SIN3-HDAC complex-associated factor

1

0

High-throughput

0.279

Low

434448

IPKG
cAMP-dependent protein kinase inhibitor gamma

1

0

High-throughput

0.279

Low

434450

YIPF1
Protein YIPF1

1

0

High-throughput

0.279

Low

121407

HYAS3
Hyaluronan synthase 3

1

0

High-throughput

0.269

Low

434411

SEM6D
Semaphorin-6D

1

0

High-throughput

0.269

Low

434418

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.269

Low

434333

SKIL
Ski-like protein

1

0

High-throughput

0.265

Low

434335

GLU2B
Glucosidase 2 subunit beta

1

0

High-throughput

0.249

Low

434337

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

434346

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

434353

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

434356

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

0

High-throughput

0.249

Low

434372

EREP3
Protein ENTREP3

1

0

High-throughput

0.249

Low

434388

RC3H1
Roquin-1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024