Protein: G6PI
Glucose-6-phosphate isomerase (GPI) (EC 5.3.1.9) (Phosphoglucose isomerase) (PGI) (Phosphohexose isomerase) (PHI)

Gene: G6PI, PGI1
Organism: Saccharomyces cerevisiae S288C
Interactions: 239
UniProt ID: P12709

Gene Ontology (top 5):
GO:0004347 - glucose-6-phosphate isomerase activity
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0005886 - plasma membrane
GO:0006094 - gluconeogenesis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

520891

G6PI
Glucose-6-phosphate isomerase

2

2

High-throughput

0.754

High

520987

RSP5
E3 ubiquitin-protein ligase RSP5

3

2

Small-scale

0.651

High

510071

SSB1
Ribosome-associated molecular chaperone SSB1

3

2

High-throughput

0.633

High

490161

HSP71
Heat shock protein SSA1

3

2

High-throughput

0.624

High

520934

SEC1
Protein transport protein SEC1

2

0

High-throughput

0.595

High

520920

SIS1
Protein SIS1

2

0

High-throughput

0.576

High

493048

HSP72
Heat shock protein SSA2

2

2

High-throughput

0.571

High

520900

HSC82
ATP-dependent molecular chaperone HSC82

2

1

High-throughput

0.571

High

521043

COFI
Cofilin

2

0

High-throughput

0.569

High

521008

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

520945

SNQ2
Protein SNQ2

1

1

High-throughput

0.541

High

521037

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

1

High-throughput

0.536

High

521073

AP1G1
AP-1 complex subunit gamma-1

1

1

High-throughput

0.536

High

520944

VPP1
V-type proton ATPase subunit a, vacuolar isoform

1

0

High-throughput

0.513

High

521024

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

439498

FUMH
Fumarate hydratase, mitochondrial

1

1

High-throughput

0.500

High

485622

IF4A
ATP-dependent RNA helicase eIF4A

1

2

High-throughput

0.500

High

520907

GBB
Guanine nucleotide-binding protein subunit beta

1

1

High-throughput

0.500

High

520913

NPR1
Nitrogen permease reactivator protein

1

1

High-throughput

0.500

High

520915

RFA1
Replication factor A protein 1

1

1

High-throughput

0.500

High

520917

KC11
Casein kinase I homolog 1

1

1

High-throughput

0.500

High

520922

RV161
Reduced viability upon starvation protein 161

1

1

High-throughput

0.500

High

520970

MSG5
Tyrosine-protein phosphatase MSG5

1

2

High-throughput

0.500

High

520972

RFC3
Replication factor C subunit 3

1

1

High-throughput

0.500

High

520984

RV167
Reduced viability upon starvation protein 167

1

1

High-throughput

0.500

High

521000

SDP1
Dual-specificity protein phosphatase SDP1

1

2

High-throughput

0.500

High

521012

UBC13
Ubiquitin-conjugating enzyme E2 13

1

1

High-throughput

0.500

High

521015

PPT1
Serine/threonine-protein phosphatase T

1

1

High-throughput

0.500

High

521017

RPN14
26S proteasome regulatory subunit RPN14

1

1

High-throughput

0.500

High

521035

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

2

High-throughput

0.500

High

521046

STE20
Serine/threonine-protein kinase STE20

1

1

High-throughput

0.500

High

521082

SKM1
Serine/threonine-protein kinase SKM1

1

2

High-throughput

0.500

High

402860

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

0

High-throughput

0.493

High

521085

COA3
Cytochrome c oxidase assembly factor 3, mitochondrial

1

0

High-throughput

0.493

High

521014

SAP4
SIT4-associating protein SAP4

1

0

High-throughput

0.486

High

420074

TOP2
DNA topoisomerase 2

1

0

High-throughput

0.479

High

420455

RAD3
General transcription and DNA repair factor IIH helicase subunit XPD

1

0

High-throughput

0.479

High

520892

RAD50
DNA repair protein RAD50

1

0

High-throughput

0.479

High

520897

EI2BA
Translation initiation factor eIF2B subunit alpha

1

0

High-throughput

0.479

High

520909

FKBP
FK506-binding protein 1

1

0

High-throughput

0.479

High

520910

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.479

High

520914

RAD53
Serine/threonine-protein kinase RAD53

1

0

High-throughput

0.479

High

520926

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.479

High

520927

MSH1
DNA mismatch repair protein MSH1, mitochondrial

1

0

High-throughput

0.479

High

520933

HRR25
Casein kinase I homolog HRR25

1

0

High-throughput

0.479

High

520940

CDC3
Cell division control protein 3

1

0

High-throughput

0.479

High

520942

CDC12
Cell division control protein 12

1

0

High-throughput

0.479

High

520959

SHE2
SWI5-dependent HO expression protein 2

1

0

High-throughput

0.479

High

520966

IMB2
Importin subunit beta-2

1

0

High-throughput

0.479

High

520968

CS111
F-box protein COS111

1

0

High-throughput

0.479

High

520969

TYDP1
Tyrosyl-DNA phosphodiesterase 1

1

0

High-throughput

0.479

High

520985

AFG3
Mitochondrial inner membrane m-AAA protease component YTA10

1

0

High-throughput

0.479

High

520995

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.479

High

521002

PSMD9
Probable 26S proteasome regulatory subunit p27

1

0

High-throughput

0.479

High

521007

LEM3
Phospholipid-transporting ATPase accessory subunit LEM3

1

0

High-throughput

0.479

High

521023

FPK1
Flippase kinase 1

1

0

High-throughput

0.479

High

521027

SIW14
Inositol phosphatase SIW14

1

0

High-throughput

0.479

High

521031

RHO4
GTP-binding protein RHO4

1

0

High-throughput

0.479

High

521032

2ABA
Protein phosphatase PP2A regulatory subunit B

1

0

High-throughput

0.479

High

521040

IMA1
Importin subunit alpha

1

0

High-throughput

0.479

High

521061

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.479

High

521086

YPT6
GTP-binding protein YPT6

1

0

High-throughput

0.479

High

334416

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.479

High

334596

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

High-throughput

0.479

High

334876

G3P1
Glyceraldehyde-3-phosphate dehydrogenase 1

1

2

High-throughput

0.479

High

342634

ENO1
Enolase 1

1

1

High-throughput

0.479

High

342836

ENO2
Enolase 2

1

1

High-throughput

0.479

High

365680

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

389206

HXKA
Hexokinase-1

1

1

High-throughput

0.479

High

389357

HXKB
Hexokinase-2

1

1

High-throughput

0.479

High

404476

RL7A
Large ribosomal subunit protein uL30A

1

1

High-throughput

0.479

High

520916

TKT1
Transketolase 1

1

1

High-throughput

0.479

High

520946

HSP7F
Heat shock protein homolog SSE1

1

3

High-throughput

0.479

High

520964

UBP13
Ubiquitin carboxyl-terminal hydrolase 13

1

1

High-throughput

0.479

High

521038

ABF2
ARS-binding factor 2, mitochondrial

1

1

High-throughput

0.479

High

521058

PUR8
Adenylosuccinate lyase

1

1

High-throughput

0.479

High

336655

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.458

High

339988

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.458

High

340596

PGK
Phosphoglycerate kinase

1

0

High-throughput

0.458

High

343342

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

343511

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.458

High

375237

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

404291

METE
5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase

1

0

High-throughput

0.458

High

406723

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

410878

PDC1
Pyruvate decarboxylase isozyme 1

1

0

High-throughput

0.458

High

421741

KAD2
Adenylate kinase

1

0

High-throughput

0.458

High

423503

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

424978

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.458

High

450265

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

520894

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.458

High

520898

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.458

High

520899

TAL1
Transaldolase

1

0

High-throughput

0.458

High

520911

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

520931

HIBCH
Small ribosomal subunit protein mS47

1

0

High-throughput

0.458

High

520936

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

520943

EF1B
Elongation factor 1-beta

1

0

High-throughput

0.458

High

520951

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

520958

TCTP
Translationally-controlled tumor protein homolog

1

0

High-throughput

0.458

High

520967

GID4
Vacuolar import and degradation protein 24

1

0

High-throughput

0.458

High

520975

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

520976

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

520982

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

520988

SAHH
Adenosylhomocysteinase

1

0

High-throughput

0.458

High

520998

MLP2
Protein MLP2

1

0

High-throughput

0.458

High

521001

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

521009

DUG1
Cys-Gly metallodipeptidase DUG1

1

0

High-throughput

0.458

High

521020

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

521028

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.458

High

521029

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

0

High-throughput

0.458

High

521033

NUM1
Nuclear migration protein NUM1

1

0

High-throughput

0.458

High

521042

ESP1
Separin

1

0

High-throughput

0.458

High

521048

OYE2
NADPH dehydrogenase 2

1

0

High-throughput

0.458

High

521051

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

521065

ZEO1
Protein ZEO1

1

0

High-throughput

0.458

High

521070

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

434726

PBS2
MAP kinase kinase PBS2

1

1

High-throughput

0.457

High

520895

KSS1
Mitogen-activated protein kinase KSS1

1

2

High-throughput

0.457

High

520902

PCNA
Proliferating cell nuclear antigen

1

1

High-throughput

0.457

High

520918

MEK1
Meiosis-specific serine/threonine-protein kinase MEK1

1

1

High-throughput

0.457

High

520923

DMC1
Meiotic recombination protein DMC1

1

1

High-throughput

0.457

High

520924

RAD51
DNA repair protein RAD51

1

1

High-throughput

0.457

High

520925

GID7
Glucose-induced degradation protein 7

1

1

High-throughput

0.457

High

520938

KNS1
Dual specificity protein kinase KNS1

1

1

High-throughput

0.457

High

520939

ARP2
Actin-related protein 2

1

1

High-throughput

0.457

High

520947

PP12
Serine/threonine-protein phosphatase PP1-2

1

1

High-throughput

0.457

High

520948

RAD24
Checkpoint protein RAD24

1

1

High-throughput

0.457

High

520950

RAD54
DNA repair and recombination protein RAD54

1

2

High-throughput

0.457

High

520953

SWE1
Mitosis inhibitor protein kinase SWE1

1

2

High-throughput

0.457

High

520956

PPZ2
Serine/threonine-protein phosphatase PP-Z2

1

1

High-throughput

0.457

High

520960

HEL1
E3 ubiquitin-protein ligase HEL1

1

1

High-throughput

0.457

High

520979

MET30
F-box protein MET30

1

1

High-throughput

0.457

High

520994

RAD26
DNA repair and recombination protein RAD26

1

1

High-throughput

0.457

High

521006

BUB1
Checkpoint serine/threonine-protein kinase BUB1

1

1

High-throughput

0.457

High

521018

CDH1
APC/C activator protein CDH1

1

1

High-throughput

0.457

High

521026

IPI3
Pre-rRNA-processing protein IPI3

1

1

High-throughput

0.457

High

521034

CDC14
Tyrosine-protein phosphatase CDC14

1

1

High-throughput

0.457

High

521036

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

1

High-throughput

0.457

High

521047

TDA1
Serine/threonine-protein kinase TDA1

1

1

High-throughput

0.457

High

521056

ERB1
Ribosome biogenesis protein ERB1

1

1

High-throughput

0.457

High

521059

UTP13
U3 small nucleolar RNA-associated protein 13

1

1

High-throughput

0.457

High

521071

CDC53
Cell division control protein 53

1

1

High-throughput

0.457

High

521072

RAD28
Radiation-sensitive protein 28

1

2

High-throughput

0.457

High

521076

YP150
Putative serine/threonine-protein kinase YPL150W

1

1

High-throughput

0.457

High

521077

YGK3
Glycogen synthase kinase-3 homolog YGK3

1

2

High-throughput

0.457

High

521079

PKH2
Serine/threonine-protein kinase PKH2

1

1

High-throughput

0.457

High

520986

SLN1
Osmosensing histidine protein kinase SLN1

1

1

High-throughput

0.445

High

520991

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

521041

YP109
ABC1 family protein YPL109C, mitochondrial

1

1

High-throughput

0.445

High

520906

PDI
Protein disulfide-isomerase

1

1

High-throughput

0.437

High

520962

RDH54
DNA repair and recombination protein RDH54

1

2

High-throughput

0.437

High

520973

RPN1
26S proteasome regulatory subunit RPN1

1

1

High-throughput

0.437

High

521004

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

521045

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.437

High

521050

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

1

High-throughput

0.437

High

521053

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

521068

NCBP2
Nuclear cap-binding protein subunit 2

1

1

High-throughput

0.437

High

521069

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

521081

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

521084

CMR1
DNA damage-binding protein CMR1

1

1

High-throughput

0.437

High

521054

PDR15
ATP-dependent permease PDR15

1

1

High-throughput

0.407

High

520893

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.310

High

520983

SAW1
Single-strand annealing weakened protein 1

2

0

High-throughput

0.307

High

520905

SPO12
Sporulation-specific protein 12

1

0

High-throughput

0.279

Low

520978

GAA1
GPI transamidase component GAA1

1

0

High-throughput

0.279

Low

419288

HAP2
Transcriptional activator HAP2

1

0

High-throughput

0.261

Low

419520

RAD1
DNA repair protein RAD1

1

0

High-throughput

0.261

Low

420208

CALM
Calmodulin

1

0

High-throughput

0.261

Low

420427

RAD10
DNA repair protein RAD10

1

0

High-throughput

0.261

Low

429603

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

436815

SWI5
Transcriptional factor SWI5

1

0

High-throughput

0.261

Low

516835

SIR4
Regulatory protein SIR4

1

0

High-throughput

0.261

Low

520896

RAD9
DNA repair protein RAD9

1

0

High-throughput

0.261

Low

520903

ABP1
Actin-binding protein

1

0

High-throughput

0.261

Low

520904

CDC23
Anaphase-promoting complex subunit CDC23

1

0

High-throughput

0.261

Low

520908

PRP6
Pre-mRNA-splicing factor 6

1

0

High-throughput

0.261

Low

520912

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.261

Low

520919

GRR1
SCF E3 ubiquitin ligase complex F-box protein GRR1

1

0

High-throughput

0.261

Low

520921

CDC10
Cell division control protein 10

1

0

High-throughput

0.261

Low

520928

MGMT
Methylated-DNA--protein-cysteine methyltransferase

1

0

High-throughput

0.261

Low

520929

RFA3
Replication factor A protein 3

1

0

High-throughput

0.261

Low

520941

HYM1
Protein HYM1

1

0

High-throughput

0.261

Low

520949

ELM1
Serine/threonine-protein kinase ELM1

1

0

High-throughput

0.261

Low

520952

SUI1
Eukaryotic translation initiation factor eIF-1

1

0

High-throughput

0.261

Low

520955

XRS2
DNA repair protein XRS2

1

0

High-throughput

0.261

Low

520957

CBF3C
Centromere DNA-binding protein complex CBF3 subunit C

1

0

High-throughput

0.261

Low

520965

PLPHP
Pyridoxal phosphate homeostasis protein

1

0

High-throughput

0.261

Low

520992

SECU
Securin

1

0

High-throughput

0.261

Low

520993

TBP6
Probable 26S proteasome subunit YTA6

1

0

High-throughput

0.261

Low

520997

UTP18
U3 small nucleolar RNA-associated protein 18

1

0

High-throughput

0.261

Low

521013

UBC11
Ubiquitin-conjugating enzyme E2-18 kDa

1

0

High-throughput

0.261

Low

521019

YG2A
Zinc finger protein YGR067C

1

0

High-throughput

0.261

Low

521025

LTO1
Protein LTO1

1

0

High-throughput

0.261

Low

521039

MEC3
DNA damage checkpoint control protein MEC3

1

0

High-throughput

0.261

Low

521044

ECM5
Protein ECM5

1

0

Small-scale

0.261

Low

521052

YD131
F-box protein YDR131C

1

0

High-throughput

0.261

Low

521055

KU80
ATP-dependent DNA helicase II subunit 2

1

0

High-throughput

0.261

Low

521057

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.261

Low

521060

NEP1
Ribosomal RNA small subunit methyltransferase NEP1

1

0

High-throughput

0.261

Low

521062

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.261

Low

521064

NOP6
Nucleolar protein 6

1

0

High-throughput

0.261

Low

521067

SOG2
Leucine-rich repeat-containing protein SOG2

1

0

High-throughput

0.261

Low

521074

MLH3
DNA mismatch repair protein MLH3

1

0

High-throughput

0.261

Low

521083

AIR2
Protein AIR2

1

0

High-throughput

0.261

Low

337160

HIS1
ATP phosphoribosyltransferase

1

0

High-throughput

0.249

Low

415874

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.249

Low

520901

STI1
Heat shock protein STI1

1

0

High-throughput

0.249

Low

520930

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

520932

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

520935

DHOM
Homoserine dehydrogenase

1

0

High-throughput

0.249

Low

520937

P5CR
Pyrroline-5-carboxylate reductase

1

0

High-throughput

0.249

Low

520954

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.249

Low

520961

HMT1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.249

Low

520963

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

520971

YGP1
Protein YGP1

1

0

High-throughput

0.249

Low

520977

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

0

Small-scale

0.249

Low

520980

DHH1
ATP-dependent RNA helicase DHH1

1

0

High-throughput

0.249

Low

520989

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

High-throughput

0.249

Low

520990

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.249

Low

520999

TM108
Protein TMA108

1

0

High-throughput

0.249

Low

521005

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.249

Low

521010

RIR4
Ribonucleoside-diphosphate reductase small chain 2

1

0

High-throughput

0.249

Low

521011

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.249

Low

521016

VID30
Vacuolar import and degradation protein 30

1

0

High-throughput

0.249

Low

521021

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.249

Low

521030

ACT
Actin

1

0

Small-scale

0.249

Low

521063

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low

521066

SGO1
Shugoshin

1

0

High-throughput

0.249

Low

521075

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

521078

RLM1
Transcription factor RLM1

1

0

High-throughput

0.249

Low

392266

H2A2
Histone H2A.2

1

0

High-throughput

0.232

Low

520303

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

0

High-throughput

0.232

Low

520974

BRL1
Nucleus export protein BRL1

1

0

High-throughput

0.232

Low

520981

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.232

Low

520996

PSF2
DNA replication complex GINS protein PSF2

1

0

High-throughput

0.232

Low

521003

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.232

Low

521022

ALG12
Dol-P-Man:Man(7)GlcNAc(2)-PP-Dol alpha-1,6-mannosyltransferase

1

0

High-throughput

0.232

Low

521049

YMB8
Uncharacterized vacuolar membrane protein YML018C

1

0

High-throughput

0.232

Low

521080

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024