Protein: TRIB3
Tribbles homolog 3 (TRB-3) (Neuronal cell death-inducible putative kinase) (SINK) (p65-interacting inhibitor of NF-kappa-B)

Gene: TRIB3
Organism: Homo sapiens
Interactions: 156
UniProt ID: Q96RU7

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0003714 - transcription corepressor activity
GO:0004860 - protein kinase inhibitor activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

728393

AKT1
RAC-alpha serine/threonine-protein kinase

4

16

Small-scale

0.909

High

1324360

STK40
Serine/threonine-protein kinase 40

4

19

High-throughput

0.903

High

832774

BCL6
B-cell lymphoma 6 protein

3

3

Small-scale

0.858

High

1108064

SQSTM
Sequestosome-1

3

8

Small-scale

0.857

High

181816

EPHB6
Ephrin type-B receptor 6

2

8

High-throughput

0.783

High

225669

AAKB2
5'-AMP-activated protein kinase subunit beta-2

2

15

High-throughput

0.783

High

913013

HNRPF
Heterogeneous nuclear ribonucleoprotein F

2

5

High-throughput

0.783

High

1225051

KANK2
KN motif and ankyrin repeat domain-containing protein 2

2

5

High-throughput

0.783

High

1337267

GLIS3
Zinc finger protein GLIS3

2

5

High-throughput

0.783

High

1347711

ZN417
Zinc finger protein 417

2

2

High-throughput

0.783

High

1402039

ZN587
Zinc finger protein 587

2

2

High-throughput

0.783

High

1402048

PAR6B
Partitioning defective 6 homolog beta

2

3

High-throughput

0.783

High

617241

ATF4
Cyclic AMP-dependent transcription factor ATF-4

8

2

Small-scale

0.758

High

891752

GSK3B
Glycogen synthase kinase-3 beta

2

19

Small-scale

0.754

High

1340785

COP1
E3 ubiquitin-protein ligase COP1

7

11

Small-scale

0.748

High

217185

MS18B
Protein Mis18-beta

2

0

High-throughput

0.742

High

1402063

TCF19
Transcription factor 19

2

0

High-throughput

0.742

High

1118386

BMPR2
Bone morphogenetic protein receptor type-2

1

2

Small-scale

0.740

High

603342

KPCA
Protein kinase C alpha type

1

18

Small-scale

0.724

High

389485

FINC
Fibronectin

1

1

Small-scale

0.713

High

1402066

GIT1
ARF GTPase-activating protein GIT1

1

8

High-throughput

0.698

High

1402056

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

4

3

Small-scale

0.697

High

584999

ZNF44
Zinc finger protein 44

1

1

High-throughput

0.691

High

1157879

DDB1
DNA damage-binding protein 1

1

4

High-throughput

0.691

High

1306969

KCC1D
Calcium/calmodulin-dependent protein kinase type 1D

1

17

High-throughput

0.691

High

1309539

MAPK5
MAP kinase-activated protein kinase 5

1

19

High-throughput

0.691

High

995213

CSK2B
Casein kinase II subunit beta

1

0

Small-scale

0.676

High

1357057

UBTD2
Ubiquitin domain-containing protein 2

2

0

High-throughput

0.655

High

1396181

RPGR1
X-linked retinitis pigmentosa GTPase regulator-interacting protein 1

2

10

High-throughput

0.654

High

520628

RARA
Retinoic acid receptor alpha

2

16

Small-scale

0.624

High

1402045

RBM4
RNA-binding protein 4

1

6

Small-scale

0.621

High

162026

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

16

Small-scale

0.618

High

363745

EGFR
Epidermal growth factor receptor

1

20

Small-scale

0.618

High

719173

MPIP1
M-phase inducer phosphatase 1

1

1

Small-scale

0.618

High

728614

AKT2
RAC-beta serine/threonine-protein kinase

1

16

Small-scale

0.618

High

953050

ACTB
Actin, cytoplasmic 1

1

6

Small-scale

0.618

High

1038342

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

19

Small-scale

0.618

High

1402038

TRIB3
Tribbles homolog 3

1

14

Small-scale

0.618

High

1402055

SNRK
SNF-related serine/threonine-protein kinase

1

17

Small-scale

0.618

High

1402064

ATF5
Cyclic AMP-dependent transcription factor ATF-5

2

9

Small-scale

0.614

High

347880

BAG3
BAG family molecular chaperone regulator 3

2

2

High-throughput

0.606

High

478718

HXB5
Homeobox protein Hox-B5

2

5

High-throughput

0.606

High

681906

RBTN2
Rhombotin-2

2

6

High-throughput

0.606

High

725104

HXC8
Homeobox protein Hox-C8

2

4

High-throughput

0.606

High

907879

CLCKA
Chloride channel protein ClC-Ka

2

3

High-throughput

0.606

High

941045

HDAC4
Histone deacetylase 4

2

10

High-throughput

0.606

High

987880

GRB2
Growth factor receptor-bound protein 2

2

13

High-throughput

0.606

High

1094722

CAF1A
Chromatin assembly factor 1 subunit A

2

1

High-throughput

0.606

High

1108854

BFSP2
Phakinin

2

4

High-throughput

0.606

High

1119776

IL16
Pro-interleukin-16 [Cleaved into: Interleukin-16

2

11

High-throughput

0.606

High

1277666

K1C26
Keratin, type I cytoskeletal 26

2

4

High-throughput

0.606

High

1289281

DTX2
Probable E3 ubiquitin-protein ligase DTX2

2

2

High-throughput

0.606

High

1347362

LMO3
LIM domain only protein 3

2

5

High-throughput

0.606

High

1358985

TEKT4
Tektin-4

2

1

High-throughput

0.606

High

1396166

PKNX2
Homeobox protein PKNOX2

2

1

High-throughput

0.606

High

1399256

SAM11
Sterile alpha motif domain-containing protein 11

2

1

High-throughput

0.606

High

1402040

PITX2
Pituitary homeobox 2

2

5

High-throughput

0.606

High

1402047

TEKT3
Tektin-3

2

1

High-throughput

0.606

High

1402052

CBX8
Chromobox protein homolog 8

2

2

High-throughput

0.606

High

1402061

AKP8L
A-kinase anchor protein 8-like

2

1

High-throughput

0.606

High

1402065

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

2

12

High-throughput

0.606

High

775461

DDIT3
DNA damage-inducible transcript 3 protein

2

0

Small-scale

0.598

High

1014589

SMAD3
Mothers against decapentaplegic homolog 3

2

11

Small-scale

0.584

High

66364

PRR19
Proline-rich protein 19

2

0

High-throughput

0.580

High

168314

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

High-throughput

0.580

High

480278

RU1C
U1 small nuclear ribonucleoprotein C

2

0

High-throughput

0.580

High

1007832

IRX6
Iroquois-class homeodomain protein IRX-6

2

0

High-throughput

0.580

High

1061836

TLE5
TLE family member 5

2

0

High-throughput

0.580

High

1081448

INCA1
Protein INCA1

2

0

High-throughput

0.580

High

1185311

F161A
Protein FAM161A

2

0

High-throughput

0.580

High

1239779

FAP20
Fanconi anemia core complex-associated protein 20

2

0

High-throughput

0.580

High

1250583

DPPA3
Developmental pluripotency-associated protein 3

2

0

High-throughput

0.580

High

1309143

MISP
Mitotic interactor and substrate of PLK1

2

0

High-throughput

0.580

High

1385250

LENG1
Leukocyte receptor cluster member 1

2

0

High-throughput

0.580

High

1402043

SPAG8
Sperm-associated antigen 8

2

0

High-throughput

0.580

High

1402046

SCNM1
Sodium channel modifier 1

2

0

High-throughput

0.580

High

1402050

IN80B
INO80 complex subunit B

2

0

High-throughput

0.580

High

1402054

EXOS5
Exosome complex component RRP46

2

0

High-throughput

0.580

High

1402057

SHFL
Shiftless antiviral inhibitor of ribosomal frameshifting protein

2

0

High-throughput

0.580

High

1402058

GPT2L
G patch domain-containing protein 2-like

2

0

High-throughput

0.580

High

1402059

SPG21
Maspardin

2

0

High-throughput

0.580

High

1402062

PADI4
Protein-arginine deiminase type-4

2

0

High-throughput

0.580

High

162667

ANM5
Protein arginine N-methyltransferase 5

1

4

High-throughput

0.573

High

372909

MYC
Myc proto-oncogene protein

1

8

Small-scale

0.561

High

714366

PML
Protein PML

1

9

Small-scale

0.561

High

1028348

MDM2
E3 ubiquitin-protein ligase Mdm2

1

3

Small-scale

0.561

High

1151974

TWST1
Twist-related protein 1

1

2

Small-scale

0.561

High

1369896

OSTF1
Osteoclast-stimulating factor 1

1

8

High-throughput

0.555

High

351588

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

2

2

High-throughput

0.553

High

1006291

CTG1B
Cancer/testis antigen 1

2

1

High-throughput

0.553

High

1180804

KLH38
Kelch-like protein 38

2

6

High-throughput

0.553

High

1369101

PCSK5
Proprotein convertase subtilisin/kexin type 5

2

3

High-throughput

0.553

High

245729

GANP
Germinal-center associated nuclear protein

1

1

Small-scale

0.552

High

1307771

SIAH1
E3 ubiquitin-protein ligase SIAH1

1

2

Small-scale

0.552

High

1402053

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

18

Small-scale

0.552

High

1402041

MDFI
MyoD family inhibitor

1

0

High-throughput

0.549

High

688114

EF1G
Elongation factor 1-gamma

1

6

High-throughput

0.541

High

1139808

SETB1
Histone-lysine N-methyltransferase SETDB1

1

4

High-throughput

0.541

High

1272530

CSN6
COP9 signalosome complex subunit 6

1

1

High-throughput

0.541

High

1371250

KAT5
Histone acetyltransferase KAT5

1

2

High-throughput

0.541

High

610839

TCPA
T-complex protein 1 subunit alpha

1

12

High-throughput

0.536

High

821518

TCPZ
T-complex protein 1 subunit zeta

1

13

High-throughput

0.536

High

876130

TCPE
T-complex protein 1 subunit epsilon

1

15

High-throughput

0.536

High

882104

TCPG
T-complex protein 1 subunit gamma

1

12

High-throughput

0.536

High

899184

TCPQ
T-complex protein 1 subunit theta

1

18

High-throughput

0.536

High

899539

TCPD
T-complex protein 1 subunit delta

1

13

High-throughput

0.536

High

1134516

NOLC1
Nucleolar and coiled-body phosphoprotein 1

1

1

High-throughput

0.536

High

1272664

DET1
DET1 homolog

1

3

High-throughput

0.536

High

1402042

TCPH
T-complex protein 1 subunit eta

1

14

High-throughput

0.536

High

1279709

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

4

High-throughput

0.534

High

336254

TIAF1
Putative TGFB1-induced anti-apoptotic factor 1

1

0

Small-scale

0.529

High

705523

GRN
Progranulin

1

0

Small-scale

0.529

High

1209153

RBM48
RNA-binding protein 48

1

0

High-throughput

0.518

High

925967

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.513

High

1324534

LTBP4
Latent-transforming growth factor beta-binding protein 4

1

1

Small-scale

0.504

High

422947

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

728992

ABC3A
DNA dC->dU-editing enzyme APOBEC-3A

1

3

Small-scale

0.501

High

1094243

ACACA
Acetyl-CoA carboxylase 1

1

8

Small-scale

0.501

High

1402067

FBX7
F-box only protein 7

1

2

High-throughput

0.501

High

248410

GDF9
Growth/differentiation factor 9

1

2

High-throughput

0.494

High

238737

TIM8A
Mitochondrial import inner membrane translocase subunit Tim8 A

1

2

High-throughput

0.489

High

1402069

TIM8B
Mitochondrial import inner membrane translocase subunit Tim8 B

1

2

High-throughput

0.489

High

1402070

TIM13
Mitochondrial import inner membrane translocase subunit Tim13

1

2

High-throughput

0.489

High

476783

RSSA
Small ribosomal subunit protein uS2

1

1

Small-scale

0.481

High

681490

PSA3
Proteasome subunit alpha type-3

1

1

Small-scale

0.481

High

1380830

TRI63
E3 ubiquitin-protein ligase TRIM63

1

14

High-throughput

0.481

High

1402049

TRI55
Tripartite motif-containing protein 55

1

14

High-throughput

0.481

High

407514

K2C1
Keratin, type II cytoskeletal 1

1

3

Small-scale

0.479

High

487655

PARP1
Poly [ADP-ribose] polymerase 1

1

6

Small-scale

0.479

High

520309

ANDR
Androgen receptor

1

16

High-throughput

0.479

High

639295

TNAP3
Tumor necrosis factor alpha-induced protein 3

1

4

Small-scale

0.479

High

764980

CTNB1
Catenin beta-1

1

3

Small-scale

0.479

High

772051

K1C9
Keratin, type I cytoskeletal 9

1

3

Small-scale

0.479

High

772969

MYH9
Myosin-9

1

7

Small-scale

0.479

High

773254

MYH10
Myosin-10

1

7

Small-scale

0.479

High

789557

PPARG
Peroxisome proliferator-activated receptor gamma

1

18

Small-scale

0.479

High

1045671

TF65
Transcription factor p65

1

8

Small-scale

0.479

High

1060628

PPARA
Peroxisome proliferator-activated receptor alpha

1

16

Small-scale

0.479

High

1388699

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

4

Small-scale

0.479

High

1402060

XPO7
Exportin-7

1

7

High-throughput

0.479

High

1402068

TRAF6
TNF receptor-associated factor 6

1

8

Small-scale

0.479

High

109497

G5E9A7
DM1 locus, WD repeat containing

1

10

High-throughput

0.470

High

1081303

Q0VAL7
C21orf58 protein

1

1

High-throughput

0.470

High

914034

RIDA
2-iminobutanoate/2-iminopropanoate deaminase

1

0

Small-scale

0.460

High

946375

CU058
Uncharacterized protein C21orf58

1

1

High-throughput

0.439

High

1333043

GALD1
Glutamine amidotransferase-like class 1 domain-containing protein 1

2

0

High-throughput

0.318

High

907183

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

1214495

PPR26
Protein phosphatase 1 regulatory subunit 26

2

0

High-throughput

0.316

High

1220035

TTC23
Tetratricopeptide repeat protein 23

2

0

High-throughput

0.316

High

1242992

CV039
Synaptic plasticity regulator PANTS

2

0

High-throughput

0.316

High

1279459

SAXO4
Stabilizer of axonemal microtubules 4

2

0

High-throughput

0.316

High

1295092

F90A1
Protein FAM90A1

2

0

High-throughput

0.316

High

1315739

SAXO1
Stabilizer of axonemal microtubules 1

2

0

High-throughput

0.316

High

1402044

UTP23
rRNA-processing protein UTP23 homolog

2

0

High-throughput

0.316

High

1402051

ARMC7
Armadillo repeat-containing protein 7

2

0

High-throughput

0.316

High


Service provided by Combinatics, Japan

Last updated: 11Aug2025