Protein: GLO2
Hydroxyacylglutathione hydrolase, mitochondrial (EC 3.1.2.6) (Glyoxalase II) (Glx II)

Gene: GLO2, HAGH
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q16775

Gene Ontology (top 5):
GO:0004416 - hydroxyacylglutathione hydrolase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

728990

ABC3A
DNA dC->dU-editing enzyme APOBEC-3A

2

0

High-throughput

0.580

High

1162772

PP16B
Protein phosphatase 1 regulatory inhibitor subunit 16B

1

2

High-throughput

0.554

High

1162782

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.549

High

1162775

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

2

High-throughput

0.541

High

445658

KCRM
Creatine kinase M-type

1

1

High-throughput

0.536

High

361264

SODC
Superoxide dismutase [Cu-Zn]

1

0

High-throughput

0.513

High

539603

PYGM
Glycogen phosphorylase, muscle form

1

0

High-throughput

0.513

High

422197

A4
Amyloid-beta precursor protein

1

2

High-throughput

0.501

High

916102

NKX25
Homeobox protein Nkx-2.5

1

0

High-throughput

0.479

High

157436

CTRO
Citron Rho-interacting kinase

1

3

High-throughput

0.479

High

186652

HMGB3
High mobility group protein B3

1

1

High-throughput

0.479

High

241823

PRKN
E3 ubiquitin-protein ligase parkin

1

2

High-throughput

0.479

High

331010

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.479

High

396215

ESR1
Estrogen receptor

1

2

High-throughput

0.479

High

532619

CH60
60 kDa heat shock protein, mitochondrial

1

1

High-throughput

0.479

High

631251

RAB5A
Ras-related protein Rab-5A

1

1

High-throughput

0.479

High

687245

HMGB2
High mobility group protein B2

1

2

High-throughput

0.479

High

901836

RAB9A
Ras-related protein Rab-9A

1

1

High-throughput

0.479

High

1057459

SOX4
Transcription factor SOX-4

1

1

High-throughput

0.479

High

1140340

KIF14
Kinesin-like protein KIF14

1

1

High-throughput

0.479

High

1141629

EEA1
Early endosome antigen 1

1

5

High-throughput

0.479

High

1162767

TRI67
Tripartite motif-containing protein 67

1

2

High-throughput

0.479

High

1162776

PKHA4
Pleckstrin homology domain-containing family A member 4

1

2

High-throughput

0.479

High

1162777

SFXN1
Sideroflexin-1

1

1

High-throughput

0.479

High

1162783

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

460828

CATB
Cathepsin B

1

1

High-throughput

0.470

High

1162774

MYOC
Myocilin

1

0

Small-scale

0.460

High

166921

MGST3
Glutathione S-transferase 3, mitochondrial

1

0

High-throughput

0.458

High

347732

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.458

High

348520

AIFM1
Apoptosis-inducing factor 1, mitochondrial

1

0

High-throughput

0.458

High

385791

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

400903

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

537241

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

559969

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

1

0

High-throughput

0.458

High

621480

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

674182

BRD2
Bromodomain-containing protein 2

1

0

High-throughput

0.458

High

680889

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.458

High

927010

ATX3
Ataxin-3

1

0

High-throughput

0.458

High

942650

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

970587

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

976295

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

978969

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.458

High

1004631

RNF4
E3 ubiquitin-protein ligase RNF4

1

0

High-throughput

0.458

High

1142554

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1162769

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1162770

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.458

High

1162771

AURKB
Aurora kinase B

1

0

High-throughput

0.458

High

1162773

SMAD5
Mothers against decapentaplegic homolog 5

1

0

High-throughput

0.458

High

1162778

PLRKT
Plasminogen receptor

1

0

High-throughput

0.458

High

1162779

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

1162780

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1162781

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

1162785

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

0

High-throughput

0.458

High

653344

HEMH
Ferrochelatase, mitochondrial

1

2

High-throughput

0.445

High

106019

APRIO
Alternative prion protein

1

1

High-throughput

0.437

High

1063285

GOGA2
Golgin subfamily A member 2

1

5

High-throughput

0.437

High

529890

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1083513

BST2
Bone marrow stromal antigen 2

1

0

High-throughput

0.282

High

390591

TFR1
Transferrin receptor protein 1

1

0

High-throughput

0.269

Low

692984

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.269

Low

787027

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

0

High-throughput

0.261

Low

851576

GATA4
Transcription factor GATA-4

1

0

High-throughput

0.261

Low

179914

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

551066

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.249

Low

581664

MYOD1
Myoblast determination protein 1

1

0

High-throughput

0.249

Low

640178

EPHA1
Ephrin type-A receptor 1

1

0

High-throughput

0.249

Low

680710

CATS
Cathepsin S

1

0

High-throughput

0.249

Low

1162768

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

1162784

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025