Protein: GLYC
Serine hydroxymethyltransferase, cytosolic (SHMT) (EC 2.1.2.1) (Glycine hydroxymethyltransferase) (Serine methylase)

Gene: GLYC, SHM2
Organism: Saccharomyces cerevisiae S288C
Interactions: 86
UniProt ID: P37291

Gene Ontology (top 5):
GO:0004372 - glycine hydroxymethyltransferase activity
GO:0005737 - cytoplasm
GO:0005739 - mitochondrion
GO:0005886 - plasma membrane
GO:0006565 - L-serine catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

490942

HSP71
Heat shock protein SSA1

3

4

High-throughput

0.633

High

493724

HSP72
Heat shock protein SSA2

3

4

High-throughput

0.624

High

510980

SSB1
Ribosome-associated molecular chaperone SSB1

3

4

High-throughput

0.624

High

366142

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.584

High

588039

HSP60
Heat shock protein 60, mitochondrial

2

2

High-throughput

0.571

High

694516

HSP7F
Heat shock protein homolog SSE1

2

5

High-throughput

0.552

High

741187

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

627933

SIS1
Protein SIS1

2

2

High-throughput

0.537

High

741203

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

3

High-throughput

0.536

High

434750

PBS2
MAP kinase kinase PBS2

1

3

High-throughput

0.515

High

696922

FRDS
Fumarate reductase 1

1

1

High-throughput

0.515

High

741196

LYS4
Homoaconitase, mitochondrial

1

1

High-throughput

0.515

High

425330

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

431358

LTE1
Guanine nucleotide exchange factor LTE1

1

0

High-throughput

0.513

High

741214

PRP11
Pre-mRNA-splicing factor PRP11

1

0

High-throughput

0.513

High

579414

GBB
Guanine nucleotide-binding protein subunit beta

1

1

High-throughput

0.500

High

741219

ARP6
Actin-like protein ARP6

1

0

High-throughput

0.493

High

605520

DBF2
Cell cycle protein kinase DBF2

1

1

High-throughput

0.489

High

741201

RHO5
GTP-binding protein RHO5

1

1

Small-scale

0.481

High

690522

CDC12
Cell division control protein 12

1

0

High-throughput

0.479

High

704323

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.479

High

543572

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

605336

HSP74
Heat shock protein SSA4

1

4

High-throughput

0.479

High

631820

RS2
Small ribosomal subunit protein uS5

1

1

High-throughput

0.479

High

680630

HS104
Heat shock protein 104

1

3

High-throughput

0.479

High

703591

PRS6A
26S proteasome regulatory subunit 6A

1

1

High-throughput

0.479

High

705070

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.479

High

741179

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

1

High-throughput

0.479

High

741184

DHH1
ATP-dependent RNA helicase DHH1

1

3

High-throughput

0.479

High

741188

TM108
Protein TMA108

1

1

High-throughput

0.479

High

741194

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

741200

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

1

High-throughput

0.479

High

741202

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.479

High

741206

TOM1
E3 ubiquitin-protein ligase TOM1

1

2

High-throughput

0.479

High

741210

RQC1
Ribosome quality control complex subunit 1

1

1

Small-scale

0.479

High

741213

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

2

Small-scale

0.479

High

741216

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

741218

PSH1
RING finger protein PSH1

1

1

High-throughput

0.470

High

340114

KPYK1
Pyruvate kinase 1

1

0

Small-scale

0.458

High

343380

TPIS
Triosephosphate isomerase

1

0

High-throughput

0.458

High

375365

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.458

High

406980

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

439512

FUMH
Fumarate hydratase, mitochondrial

1

0

High-throughput

0.458

High

498497

METK1
S-adenosylmethionine synthase 1

1

0

Small-scale

0.458

High

524262

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

605008

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

659774

SBA1
Co-chaperone protein SBA1

1

0

High-throughput

0.458

High

700846

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

741178

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

741180

DNPEP
Aspartyl aminopeptidase 4

1

0

High-throughput

0.458

High

741189

SER33
D-3-phosphoglycerate dehydrogenase 2

1

0

Small-scale

0.458

High

741190

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.458

High

741197

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.458

High

741205

ESP1
Separin

1

0

High-throughput

0.458

High

741209

SEG1
Eisosome protein SEG1

1

0

Small-scale

0.458

High

701202

SUI1
Eukaryotic translation initiation factor eIF-1

1

1

High-throughput

0.457

High

741183

CAJ1
Protein CAJ1

1

2

High-throughput

0.445

High

741191

ULP2
Ubiquitin-like-specific protease 2

1

1

High-throughput

0.439

High

741204

ULP1
Ubiquitin-like-specific protease 1

1

1

High-throughput

0.439

High

413452

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.437

High

661969

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.437

High

741176

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

741181

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

1

Small-scale

0.437

High

741185

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.437

High

741211

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.437

High

741212

TFC6
Transcription factor tau 91 kDa subunit

1

1

High-throughput

0.437

High

741215

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

367967

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

687355

EF2
Elongation factor 2

1

2

High-throughput

0.407

High

741207

GCN5
Histone acetyltransferase GCN5

1

1

High-throughput

0.407

High

602995

BAS1
Myb-like DNA-binding protein BAS1

2

0

High-throughput

0.323

High

540077

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

2

0

High-throughput

0.307

High

741193

GCN20
Protein GCN20

2

0

High-throughput

0.307

High

741177

RFC3
Replication factor C subunit 3

1

0

High-throughput

0.279

Low

634016

BUD3
Bud site selection protein 3

1

0

High-throughput

0.269

Low

741217

TGL5
Triacylglycerol lipase 5

1

0

High-throughput

0.269

Low

741186

LSM5
U6 snRNA-associated Sm-like protein LSm5

1

0

High-throughput

0.265

Low

429684

RPAC1
DNA-directed RNA polymerases I and III subunit RPAC1

1

0

High-throughput

0.261

Low

741199

SEH1
Nucleoporin SEH1

1

0

High-throughput

0.261

Low

604779

PSB4
Proteasome subunit beta type-4

1

0

Small-scale

0.249

Low

741182

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

741192

BRE2
COMPASS component BRE2

1

0

Small-scale

0.249

Low

741195

VATG
V-type proton ATPase subunit G

1

0

High-throughput

0.249

Low

741198

ACS2
Acetyl-coenzyme A synthetase 2

1

0

Small-scale

0.249

Low

741208

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.249

Low

741220

H2AZ
Histone H2A.Z

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024