Protein: IL2RG
Cytokine receptor common subunit gamma (Interleukin-2 receptor subunit gamma) (IL-2 receptor subunit gamma) (IL-2R subunit gamma) (IL-2RG) (gammaC) (p64) (CD antigen CD132)

Gene: IL2RG
Organism: Homo sapiens
Interactions: 46
UniProt ID: P31785

Gene Ontology (top 5):
GO:0002335 - mature B cell differentiation
GO:0002361 - CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
GO:0002639 - positive regulation of immunoglobulin production
GO:0004896 - cytokine receptor activity
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

728671

IL2
Interleukin-2

4

2

Small-scale

0.887

High

728666

IL15
Interleukin-15

3

1

Small-scale

0.858

High

599165

IL7RA
Interleukin-7 receptor subunit alpha

3

2

Small-scale

0.827

High

658852

PTPRD
Receptor-type tyrosine-protein phosphatase delta

2

18

High-throughput

0.789

High

575812

IL2RB
Interleukin-2 receptor subunit beta

8

19

Small-scale

0.748

High

728668

JAK3
Tyrosine-protein kinase JAK3

5

18

Small-scale

0.699

High

424317

IL4
Interleukin-4

1

3

Small-scale

0.691

High

728687

IL21
Interleukin-21

1

0

Small-scale

0.654

High

561006

IL7
Interleukin-7

3

1

Small-scale

0.650

High

728665

IL2RG
Cytokine receptor common subunit gamma

1

17

Small-scale

0.647

High

728693

FLVC1
Choline/ethanolamine transporter FLVCR1

3

0

High-throughput

0.638

High

728683

REEP6
Receptor expression-enhancing protein 6

4

1

High-throughput

0.630

High

728688

CD320
CD320 antigen

2

10

High-throughput

0.628

High

665028

IL4RA
Interleukin-4 receptor subunit alpha

2

16

Small-scale

0.611

High

728670

KR108
Keratin-associated protein 10-8

2

2

High-throughput

0.606

High

728680

KRA57
Keratin-associated protein 5-7

2

3

High-throughput

0.606

High

253308

JAK2
Tyrosine-protein kinase JAK2

2

20

Small-scale

0.601

High

728681

NT2NA
Notch homolog 2 N-terminal-like protein A

2

8

High-throughput

0.573

High

728676

STK4
Serine/threonine-protein kinase 4

1

16

High-throughput

0.541

High

728674

I13R1
Interleukin-13 receptor subunit alpha-1

1

19

Small-scale

0.515

High

728678

SHB
SH2 domain-containing adapter protein B

1

20

Small-scale

0.501

High

412935

CPNS1
Calpain small subunit 1

1

3

Small-scale

0.481

High

728669

KR103
Keratin-associated protein 10-3

1

2

High-throughput

0.481

High

378610

IL2RA
Interleukin-2 receptor subunit alpha

1

2

Small-scale

0.479

High

658638

JAK1
Tyrosine-protein kinase JAK1

1

20

Small-scale

0.479

High

711246

SHC1
SHC-transforming protein 1

1

20

Small-scale

0.479

High

728667

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

5

Small-scale

0.479

High

728673

GRB2
Growth factor receptor-bound protein 2

1

20

High-throughput

0.479

High

728677

GRB10
Growth factor receptor-bound protein 10

1

20

Small-scale

0.479

High

728684

NED4L
E3 ubiquitin-protein ligase NEDD4-like

1

5

Small-scale

0.479

High

728692

ERRFI
ERBB receptor feedback inhibitor 1

1

0

Small-scale

0.460

High

728685

S10AD
Protein S100-A13

1

5

High-throughput

0.445

High

728691

LMCD1
LIM and cysteine-rich domains protein 1

1

1

High-throughput

0.445

High

298253

BODG
Gamma-butyrobetaine dioxygenase

1

0

High-throughput

0.426

High

357916

CYB5
Cytochrome b5

1

0

High-throughput

0.426

High

599505

FAAA
Fumarylacetoacetase

1

0

High-throughput

0.426

High

709206

IMPA1
Inositol monophosphatase 1

1

0

High-throughput

0.426

High

728682

UBCP1
Ubiquitin-like domain-containing CTD phosphatase 1

1

0

High-throughput

0.426

High

728686

GRPE1
GrpE protein homolog 1, mitochondrial

1

0

High-throughput

0.426

High

728689

ADPPT
L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase

1

0

High-throughput

0.426

High

728672

GMFB
Glia maturation factor beta

1

2

High-throughput

0.407

High

728675

REEP5
Receptor expression-enhancing protein 5

1

1

High-throughput

0.407

High

728690

NFIP2
NEDD4 family-interacting protein 2

1

0

High-throughput

0.249

Low

465942

CO1A2
Collagen alpha-2(I) chain

1

0

High-throughput

0.232

Low

728679

PTRD1
Putative peptidyl-tRNA hydrolase PTRHD1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025