Protein: FBX25
F-box only protein 25

Gene: FBX25, FBXO25
Organism: Homo sapiens
Interactions: 202
UniProt ID: Q8TCJ0

Gene Ontology (top 5):
GO:0000151 - ubiquitin ligase complex
GO:0003779 - actin binding
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

992272

SKP1
S-phase kinase-associated protein 1

6

3

Small-scale

0.733

High

1112615

CUL1
Cullin-1

4

4

Small-scale

0.694

High

1061263

RHG01
Rho GTPase-activating protein 1

3

0

High-throughput

0.638

High

1349748

UB2E3
Ubiquitin-conjugating enzyme E2 E3

2

1

High-throughput

0.611

High

622466

ELK1
ETS domain-containing protein Elk-1

2

0

Small-scale

0.598

High

461741

HS90A
Heat shock protein HSP 90-alpha

2

2

High-throughput

0.584

High

952975

ACTB
Actin, cytoplasmic 1

1

6

High-throughput

0.581

High

933695

PSMD4
26S proteasome non-ATPase regulatory subunit 4

2

0

Small-scale

0.569

High

1291081

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

2

High-throughput

0.536

High

1085138

SCRN1
Secernin-1

1

0

High-throughput

0.513

High

130995

HIP1
Huntingtin-interacting protein 1

1

8

Small-scale

0.501

High

227174

DYRK3
Dual specificity tyrosine-phosphorylation-regulated kinase 3

1

2

Small-scale

0.501

High

354740

PAK4
Serine/threonine-protein kinase PAK 4

1

1

Small-scale

0.501

High

437279

K2C8
Keratin, type II cytoskeletal 8

1

2

Small-scale

0.501

High

593449

PGFRA
Platelet-derived growth factor receptor alpha

1

2

Small-scale

0.501

High

669139

ARBK1
Beta-adrenergic receptor kinase 1

1

1

Small-scale

0.501

High

772509

IRS1
Insulin receptor substrate 1

1

1

Small-scale

0.501

High

778082

VGFR2
Vascular endothelial growth factor receptor 2

1

1

Small-scale

0.501

High

860850

RS10
Small ribosomal subunit protein eS10

1

1

Small-scale

0.501

High

897907

CDK9
Cyclin-dependent kinase 9

1

3

Small-scale

0.501

High

916106

NKX25
Homeobox protein Nkx-2.5

1

1

Small-scale

0.501

High

957142

UB2D3
Ubiquitin-conjugating enzyme E2 D3

1

1

Small-scale

0.501

High

1026899

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

1

Small-scale

0.501

High

1085901

TWF1
Twinfilin-1

1

3

Small-scale

0.501

High

1091779

PP1R8
Nuclear inhibitor of protein phosphatase 1

1

1

Small-scale

0.501

High

1203201

ODFP2
Outer dense fiber protein 2

1

10

Small-scale

0.501

High

1332273

WSDU1
WD repeat, SAM and U-box domain-containing protein 1

1

1

Small-scale

0.501

High

1349754

TBX5
T-box transcription factor TBX5

1

2

Small-scale

0.501

High

1349761

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

Small-scale

0.501

High

1349771

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

2

Small-scale

0.501

High

1349777

LMCD1
LIM and cysteine-rich domains protein 1

1

2

Small-scale

0.501

High

1349780

KS6B2
Ribosomal protein S6 kinase beta-2

1

2

Small-scale

0.501

High

1349781

UBQL2
Ubiquilin-2

1

4

Small-scale

0.501

High

1349785

UBQL1
Ubiquilin-1

1

4

Small-scale

0.501

High

1349790

SAMH1
Deoxynucleoside triphosphate triphosphohydrolase SAMHD1

1

1

Small-scale

0.501

High

231509

ORC4
Origin recognition complex subunit 4

1

1

High-throughput

0.481

High

1349752

CK5P2
CDK5 regulatory subunit-associated protein 2

1

10

High-throughput

0.481

High

244268

NUAK1
NUAK family SNF1-like kinase 1

1

0

Small-scale

0.480

High

252122

IF4E2
Eukaryotic translation initiation factor 4E type 2

1

0

Small-scale

0.480

High

298419

DNJC8
DnaJ homolog subfamily C member 8

1

0

Small-scale

0.480

High

363597

EGFR
Epidermal growth factor receptor

1

0

Small-scale

0.480

High

451548

CENPB
Major centromere autoantigen B

1

0

Small-scale

0.480

High

603319

KPCA
Protein kinase C alpha type

1

0

Small-scale

0.480

High

679377

DNJB2
DnaJ homolog subfamily B member 2

1

0

Small-scale

0.480

High

772399

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

0

Small-scale

0.480

High

1025126

TF2B
Transcription initiation factor IIB

1

0

Small-scale

0.480

High

1064891

PPID
Peptidyl-prolyl cis-trans isomerase D

1

0

Small-scale

0.480

High

1100914

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

Small-scale

0.480

High

1210489

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

Small-scale

0.480

High

1294094

DDX42
ATP-dependent RNA helicase DDX42

1

0

Small-scale

0.480

High

1309432

APLF
Aprataxin and PNK-like factor

1

0

Small-scale

0.480

High

1315818

AN13A
Ankyrin repeat domain-containing protein 13A

1

0

Small-scale

0.480

High

1322850

EID3
EP300-interacting inhibitor of differentiation 3

1

0

Small-scale

0.480

High

1331071

TEANC
Transcription elongation factor A N-terminal and central domain-containing protein

1

0

Small-scale

0.480

High

1334680

SERB1
SERPINE1 mRNA-binding protein 1

1

0

Small-scale

0.480

High

1349743

TCP1L
T-complex protein 10A homolog 1

1

0

Small-scale

0.480

High

1349745

TRUB1
Pseudouridylate synthase TRUB1

1

0

Small-scale

0.480

High

1349762

TCAL2
Transcription elongation factor A protein-like 2

1

0

Small-scale

0.480

High

1349766

ILRUN
Protein ILRUN

1

0

Small-scale

0.480

High

1349769

SYTL2
Synaptotagmin-like protein 2

1

0

Small-scale

0.480

High

1349774

ING3
Inhibitor of growth protein 3

1

0

Small-scale

0.480

High

1349776

MAT2B
Methionine adenosyltransferase 2 subunit beta

1

0

Small-scale

0.480

High

1349783

PADI4
Protein-arginine deiminase type-4

1

0

Small-scale

0.480

High

1349792

RBM8A
RNA-binding protein 8A

1

0

Small-scale

0.480

High

1349793

EPN1
Epsin-1

1

0

Small-scale

0.480

High

123779

MYO1C
Unconventional myosin-Ic

1

10

High-throughput

0.479

High

128024

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

4

High-throughput

0.479

High

162639

ANM5
Protein arginine N-methyltransferase 5

1

1

High-throughput

0.479

High

169121

ML12B
Myosin regulatory light chain 12B

1

2

High-throughput

0.479

High

173115

XPO1
Exportin-1

1

1

High-throughput

0.479

High

211000

PSMD3
26S proteasome non-ATPase regulatory subunit 3

1

1

High-throughput

0.479

High

220955

XPOT
Exportin-T

1

1

High-throughput

0.479

High

227926

MYO1B
Unconventional myosin-Ib

1

9

High-throughput

0.479

High

318363

MYO1D
Unconventional myosin-Id

1

11

High-throughput

0.479

High

390115

ALBU
Albumin

1

1

High-throughput

0.479

High

408110

TBB4A
Tubulin beta-4A chain

1

8

High-throughput

0.479

High

442415

GELS
Gelsolin

1

1

High-throughput

0.479

High

443892

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

1

3

High-throughput

0.479

High

445984

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

468627

HS90B
Heat shock protein HSP 90-beta

1

3

High-throughput

0.479

High

474846

VIME
Vimentin

1

5

High-throughput

0.479

High

535324

BIP
Endoplasmic reticulum chaperone BiP

1

3

High-throughput

0.479

High

537569

HSP7C
Heat shock cognate 71 kDa protein

1

2

High-throughput

0.479

High

552650

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.479

High

565982

EF2
Elongation factor 2

1

1

High-throughput

0.479

High

570518

GFAP
Glial fibrillary acidic protein

1

6

High-throughput

0.479

High

576803

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

610411

PRS6A
26S proteasome regulatory subunit 6A

1

6

High-throughput

0.479

High

660121

COF1
Cofilin-1

1

3

High-throughput

0.479

High

666761

MYL9
Myosin regulatory light polypeptide 9

1

2

High-throughput

0.479

High

669950

MCM3
DNA replication licensing factor MCM3

1

1

High-throughput

0.479

High

772917

MYH9
Myosin-9

1

8

High-throughput

0.479

High

773231

MYH10
Myosin-10

1

8

High-throughput

0.479

High

776835

MYH11
Myosin-11

1

8

High-throughput

0.479

High

801425

HSPA9
Stress-70 protein, mitochondrial

1

5

High-throughput

0.479

High

821468

TCPZ
T-complex protein 1 subunit zeta

1

3

High-throughput

0.479

High

899148

TCPQ
T-complex protein 1 subunit theta

1

5

High-throughput

0.479

High

899670

AT1A2
Sodium/potassium-transporting ATPase subunit alpha-2

1

2

High-throughput

0.479

High

912979

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

1

High-throughput

0.479

High

913363

MSH6
DNA mismatch repair protein Msh6

1

1

High-throughput

0.479

High

921969

COPA
Coatomer subunit alpha

1

1

High-throughput

0.479

High

931017

HSP72
Heat shock-related 70 kDa protein 2

1

2

High-throughput

0.479

High

934121

XPO2
Exportin-2

1

3

High-throughput

0.479

High

968766

PRS4
26S proteasome regulatory subunit 4

1

3

High-throughput

0.479

High

968999

PRS8
26S proteasome regulatory subunit 8

1

3

High-throughput

0.479

High

983899

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

Small-scale

0.479

High

987131

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

1

High-throughput

0.479

High

993256

ACTG
Actin, cytoplasmic 2

1

6

High-throughput

0.479

High

997047

TBA4A
Tubulin alpha-4A chain

1

3

High-throughput

0.479

High

997439

TBB4B
Tubulin beta-4B chain

1

8

High-throughput

0.479

High

1032510

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

1

High-throughput

0.479

High

1051813

EF1A2
Elongation factor 1-alpha 2

1

1

High-throughput

0.479

High

1093275

FLII
Protein flightless-1 homolog

1

1

High-throughput

0.479

High

1098068

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

1

High-throughput

0.479

High

1106012

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

High-throughput

0.479

High

1108624

TBB3
Tubulin beta-3 chain

1

8

High-throughput

0.479

High

1118532

TBB2A
Tubulin beta-2A chain

1

8

High-throughput

0.479

High

1151025

PCH2
Pachytene checkpoint protein 2 homolog

1

4

High-throughput

0.479

High

1160694

DREB
Drebrin

1

1

High-throughput

0.479

High

1201005

ACTBL
Beta-actin-like protein 2

1

6

High-throughput

0.479

High

1229834

CYTSA
Cytospin-A

1

8

High-throughput

0.479

High

1277759

MYH14
Myosin-14

1

8

High-throughput

0.479

High

1349747

FBX32
F-box only protein 32

1

1

High-throughput

0.479

High

1349755

DNJC7
DnaJ homolog subfamily C member 7

1

3

High-throughput

0.479

High

1349756

TCPH
T-complex protein 1 subunit eta

1

4

High-throughput

0.479

High

1349758

TBA1C
Tubulin alpha-1C chain

1

4

High-throughput

0.479

High

1349760

UACA
Uveal autoantigen with coiled-coil domains and ankyrin repeats

1

6

High-throughput

0.479

High

1349763

UN45A
Protein unc-45 homolog A

1

4

High-throughput

0.479

High

1349764

TBB1
Tubulin beta-1 chain

1

11

High-throughput

0.479

High

1349778

RAI14
Ankycorbin

1

1

High-throughput

0.479

High

1349779

MYO1A
Unconventional myosin-Ia

1

10

High-throughput

0.479

High

1349784

MYO6
Unconventional myosin-VI

1

6

High-throughput

0.479

High

1349786

SMC3
Structural maintenance of chromosomes protein 3

1

5

High-throughput

0.479

High

1349787

RUVB2
RuvB-like 2

1

1

High-throughput

0.479

High

1349788

RUVB1
RuvB-like 1

1

1

High-throughput

0.479

High

1349791

MYO5A
Unconventional myosin-Va

1

6

High-throughput

0.479

High

117167

J9JIF5
CXXC-type zinc finger protein 4

1

0

High-throughput

0.460

High

1288856

GTD2A
General transcription factor II-I repeat domain-containing protein 2A

1

0

High-throughput

0.460

High

171283

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

High-throughput

0.458

High

447245

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

576249

PO2F1
POU domain, class 2, transcription factor 1

1

0

Small-scale

0.458

High

620487

NUCL
Nucleolin

1

0

High-throughput

0.458

High

697602

PYR1
Multifunctional protein CAD

1

0

High-throughput

0.458

High

716915

RL12
Large ribosomal subunit protein uL11

1

0

High-throughput

0.458

High

727896

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

756280

MCM7
DNA replication licensing factor MCM7

1

0

High-throughput

0.458

High

841840

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

0

High-throughput

0.458

High

862916

IQGA1
Ras GTPase-activating-like protein IQGAP1

1

0

High-throughput

0.458

High

936815

NP1L1
Nucleosome assembly protein 1-like 1

1

0

High-throughput

0.458

High

938598

PSA
Puromycin-sensitive aminopeptidase

1

0

High-throughput

0.458

High

940278

SYMC
Methionine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

969327

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.458

High

1005333

IGBP1
Immunoglobulin-binding protein 1

1

0

High-throughput

0.458

High

1163081

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.458

High

1349749

SH3K1
SH3 domain-containing kinase-binding protein 1

1

0

High-throughput

0.458

High

1349751

PAWR
PRKC apoptosis WT1 regulator protein

1

0

High-throughput

0.458

High

1349775

TMOD3
Tropomodulin-3

1

0

High-throughput

0.458

High

1349782

BAG5
BAG family molecular chaperone regulator 5

1

0

High-throughput

0.458

High

1098878

KGP2
cGMP-dependent protein kinase 2

1

2

Small-scale

0.457

High

1349750

HMCES
Abasic site processing protein HMCES

1

1

Small-scale

0.457

High

1349753

STAC
SH3 and cysteine-rich domain-containing protein

1

2

Small-scale

0.457

High

1349765

RABE2
Rab GTPase-binding effector protein 2

1

9

Small-scale

0.457

High

1349767

RPAP3
RNA polymerase II-associated protein 3

1

3

Small-scale

0.457

High

209625

SERA
D-3-phosphoglycerate dehydrogenase

1

1

High-throughput

0.437

High

334854

IPO7
Importin-7

1

2

High-throughput

0.437

High

420632

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

2

High-throughput

0.437

High

547657

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

1

High-throughput

0.437

High

598150

AT2A2
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2

1

2

High-throughput

0.437

High

610791

TCPA
T-complex protein 1 subunit alpha

1

4

High-throughput

0.437

High

680440

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

3

High-throughput

0.437

High

876083

TCPE
T-complex protein 1 subunit epsilon

1

4

High-throughput

0.437

High

899494

TCPD
T-complex protein 1 subunit delta

1

3

High-throughput

0.437

High

1136559

PSMD6
26S proteasome non-ATPase regulatory subunit 6

1

2

High-throughput

0.437

High

1214732

ATD3B
ATPase family AAA domain-containing protein 3B

1

5

High-throughput

0.437

High

1245564

Q6PK50
HSP90AB1 protein

1

3

High-throughput

0.437

High

1250740

MPRIP
Myosin phosphatase Rho-interacting protein

1

9

High-throughput

0.437

High

1328101

TTC9C
Tetratricopeptide repeat protein 9C

1

3

High-throughput

0.437

High

1349772

ATD3A
ATPase family AAA domain-containing protein 3A

1

3

High-throughput

0.437

High

1349773

PNPO
Pyridoxine-5'-phosphate oxidase

3

0

High-throughput

0.347

High

890990

NDUV1
NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial

1

0

High-throughput

0.268

Low

160931

TMG1
Transmembrane gamma-carboxyglutamic acid protein 1

1

0

Small-scale

0.261

Low

161828

RIOK3
Serine/threonine-protein kinase RIO3

1

0

Small-scale

0.261

Low

221271

DCX
Neuronal migration protein doublecortin

1

0

Small-scale

0.261

Low

720277

UFO
Tyrosine-protein kinase receptor UFO

1

0

Small-scale

0.261

Low

908216

BMX
Cytoplasmic tyrosine-protein kinase BMX

1

0

Small-scale

0.261

Low

1081591

BRME1
Break repair meiotic recombinase recruitment factor 1

1

0

Small-scale

0.261

Low

1238420

JHY
Jhy protein homolog

1

0

Small-scale

0.261

Low

1308452

PRR15
Proline-rich protein 15

1

0

Small-scale

0.261

Low

1339624

TNIP2
TNFAIP3-interacting protein 2

1

0

Small-scale

0.261

Low

1347988

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.261

Low

1349200

PI42C
Phosphatidylinositol 5-phosphate 4-kinase type-2 gamma

1

0

Small-scale

0.261

Low

1349744

RHBL4
Rhomboid-related protein 4

1

0

Small-scale

0.261

Low

1349759

CHOLN
Protein cholesin

1

0

Small-scale

0.261

Low

1349768

IL21
Interleukin-21

1

0

Small-scale

0.261

Low

1349770

LUC7L
Putative RNA-binding protein Luc7-like 1

1

0

Small-scale

0.261

Low

1349789

TMA7
Translation machinery-associated protein 7

1

0

Small-scale

0.261

Low

76560

B4DYC6
cDNA FLJ60958, highly similar to Homo sapiens SGT1, suppressor of G2 allele of SKP1

1

0

High-throughput

0.249

Low

124414

HAX1
HCLS1-associated protein X-1

1

0

Small-scale

0.249

Low

417612

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

418292

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.249

Low

1349746

BORC5
BLOC-1-related complex subunit 5

1

0

High-throughput

0.249

Low

1349757

Q9BPW0
Serine/threonine-protein phosphatase

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025