Protein: SPRC
SPARC (Basement-membrane protein 40) (BM-40) (Osteonectin) (ON) (Secreted protein acidic and rich in cysteine)

Gene: SPRC, SPARC
Organism: Homo sapiens
Interactions: 47
UniProt ID: P09486

Gene Ontology (top 5):
GO:0001937 - negative regulation of endothelial cell proliferation
GO:0005509 - calcium ion binding
GO:0005518 - collagen binding
GO:0005576 - extracellular region
GO:0005604 - basement membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

341349

PLMN
Plasminogen

2

2

Small-scale

0.812

High

358456

CO1A1
Collagen alpha-1(I) chain

3

5

Small-scale

0.646

High

358630

CO3A1

2

5

Small-scale

0.629

High

451067

VEGFA
Vascular endothelial growth factor A, long form

2

3

Small-scale

0.602

High

350947

PDGFB
Platelet-derived growth factor subunit B

2

3

Small-scale

0.595

High

451077

RASF7
Ras association domain-containing protein 7

2

0

High-throughput

0.585

High

451089

MYOC
Myocilin

1

3

Small-scale

0.552

High

451068

VCAM1
Vascular cell adhesion protein 1

1

2

Small-scale

0.536

High

451079

ILK
Integrin-linked protein kinase

1

1

Small-scale

0.536

High

451081

RNPS1
RNA-binding protein with serine-rich domain 1

1

1

High-throughput

0.536

High

451091

CSTL1
Cystatin-like 1

1

1

High-throughput

0.536

High

451072

TGFR2
TGF-beta receptor type-2

1

5

Small-scale

0.527

High

451078

ILF3
Interleukin enhancer-binding factor 3

1

1

High-throughput

0.515

High

451094

STAB1
Stabilin-1

1

4

Small-scale

0.515

High

451096

TBC14
TBC1 domain family member 14

1

1

High-throughput

0.515

High

451063

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.513

High

451076

PP4C
Serine/threonine-protein phosphatase 4 catalytic subunit

1

0

High-throughput

0.513

High

451080

CASP8
Caspase-8

1

0

Small-scale

0.513

High

372981

VTNC
Vitronectin

1

3

Small-scale

0.501

High

393979

A4
Amyloid-beta precursor protein

1

2

Small-scale

0.501

High

439259

MMP3
Stromelysin-1

1

3

Small-scale

0.501

High

451065

COBA1

1

5

Small-scale

0.501

High

451069

CO5A1

1

5

Small-scale

0.501

High

451070

TENA
Tenascin

1

8

Small-scale

0.501

High

451073

COIA1
Collagen alpha-1(XVIII) chain [Cleaved into: Endostatin; Non-collagenous domain 1

1

5

Small-scale

0.501

High

451083

CR3L3
Cyclic AMP-responsive element-binding protein 3-like protein 3

1

2

High-throughput

0.489

High

451066

XRCC6
X-ray repair cross-complementing protein 6

1

0

High-throughput

0.486

High

451085

CPEB2
Cytoplasmic polyadenylation element-binding protein 2

1

2

Small-scale

0.481

High

451097

UBQL1
Ubiquilin-1

1

2

Small-scale

0.481

High

451075

CATK
Cathepsin K

1

0

Small-scale

0.480

High

345752

MYC
Myc proto-oncogene protein

1

2

High-throughput

0.479

High

361732

FIBA
Fibrinogen alpha chain [Cleaved into: Fibrinopeptide A; Fibrinogen alpha chain]

1

2

Small-scale

0.479

High

373563

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

376360

PDGFA
Platelet-derived growth factor subunit A

1

3

Small-scale

0.479

High

434606

TSP1
Thrombospondin-1

1

3

Small-scale

0.479

High

451082

BGH3
Transforming growth factor-beta-induced protein ig-h3

1

1

Small-scale

0.479

High

451084

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.479

High

451074

VHL
von Hippel-Lindau disease tumor suppressor

1

0

Small-scale

0.460

High

451086

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

451093

DISC1
Disrupted in schizophrenia 1 protein

1

3

High-throughput

0.417

High

451088

PHOP2
Pyridoxal phosphate phosphatase PHOSPHO2

1

0

High-throughput

0.269

Low

451090

LSG1
Large subunit GTPase 1 homolog

1

0

High-throughput

0.269

Low

451087

ZN579
Zinc finger protein 579

1

0

High-throughput

0.265

Low

451071

DNMT1
DNA

1

0

Small-scale

0.249

Low

451092

SEBOX
Homeobox protein SEBOX

1

0

Small-scale

0.249

Low

451095

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

451064

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024