Protein: NFS1
Cysteine desulfurase, mitochondrial (EC 2.8.1.7) (tRNA-splicing protein SPL1)

Gene: NFS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 50
UniProt ID: P25374

Gene Ontology (top 5):
GO:0002098 - tRNA wobble uridine modification
GO:0005634 - nucleus
GO:0005739 - mitochondrion
GO:0005829 - cytosol
GO:0006879 - intracellular iron ion homeostasis

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

673394

ISD11
Protein ISD11

13

2

Small-scale

0.983

High

673385

ISU1
Iron sulfur cluster assembly protein 1, mitochondrial

9

7

Small-scale

0.966

High

673389

FRDA
Frataxin homolog, mitochondrial

6

4

Small-scale

0.933

High

673367

ACPM
Acyl carrier protein, mitochondrial

3

3

Small-scale

0.827

High

673392

ADRX
Adrenodoxin homolog, mitochondrial

1

1

Small-scale

0.647

High

673391

ISU2
Iron sulfur cluster assembly protein 2, mitochondrial

1

7

High-throughput

0.618

High

673370

HSP78
Heat shock protein 78, mitochondrial

2

2

High-throughput

0.584

High

399801

COX4
Cytochrome c oxidase subunit 4, mitochondrial

2

0

Small-scale

0.559

High

673373

MIC60
MICOS complex subunit MIC60

2

0

High-throughput

0.559

High

526017

HSP72
Heat shock protein SSA2

2

6

High-throughput

0.552

High

543943

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.552

High

656704

KC12
Casein kinase I homolog 2

1

0

Small-scale

0.537

High

574555

YAK1
Dual specificity protein kinase YAK1

1

5

High-throughput

0.536

High

454409

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.513

High

673382

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.513

High

673393

SKS1
Serine/threonine-protein kinase SKS1

1

0

High-throughput

0.513

High

416865

CDC25
Cell division control protein 25

1

1

High-throughput

0.501

High

673379

BNI1
Protein BNI1

1

1

High-throughput

0.501

High

673371

OAF3
Oleate activated transcription factor 3

1

0

High-throughput

0.493

High

460950

LTE1
Guanine nucleotide exchange factor LTE1

1

2

High-throughput

0.489

High

673376

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

0

Small-scale

0.480

High

673390

THTR
Thiosulfate sulfurtransferase TUM1

1

0

Small-scale

0.480

High

360644

COX2
Cytochrome c oxidase subunit 2

1

1

Small-scale

0.479

High

453113

QCR1
Cytochrome b-c1 complex subunit 1, mitochondrial

1

3

Small-scale

0.479

High

510233

HSP77
Import motor subunit, mitochondrial

1

7

High-throughput

0.479

High

646310

RAD53
Serine/threonine-protein kinase RAD53

1

1

High-throughput

0.479

High

670380

SIS1
Protein SIS1

1

1

High-throughput

0.479

High

673377

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

673381

TOM22
Mitochondrial import receptor subunit TOM22

1

1

High-throughput

0.479

High

673383

HST2
NAD-dependent protein deacetylase HST2

1

3

High-throughput

0.479

High

673388

IRC20
Uncharacterized ATP-dependent helicase IRC20

1

3

Small-scale

0.479

High

360323

COX1
Cytochrome c oxidase subunit 1

1

0

Small-scale

0.458

High

382840

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

453076

COX9
Cytochrome c oxidase subunit 9, mitochondrial

1

0

Small-scale

0.458

High

465319

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

Small-scale

0.458

High

470672

QCR8
Cytochrome b-c1 complex subunit 8, mitochondrial

1

0

Small-scale

0.458

High

673365

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

0

High-throughput

0.458

High

673366

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

673368

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

673369

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

673372

FRE2
Ferric/cupric reductase transmembrane component 2

1

0

High-throughput

0.458

High

673378

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

673386

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

673387

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

506502

YL016
Putative truncated guanine nucleotide exchange factor SDC25

1

1

High-throughput

0.457

High

523170

HSP71
Heat shock protein SSA1

1

6

High-throughput

0.445

High

673384

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.438

High

673375

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

673380

TCPQ
T-complex protein 1 subunit theta

1

2

High-throughput

0.407

High

673374

SRO77
Lethal(2) giant larvae protein homolog SRO77

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025