Protein: HEMH
Ferrochelatase, mitochondrial (EC 4.98.1.1) (Heme synthase) (Protoheme ferro-lyase)

Gene: HEMH, HEM15
Organism: Saccharomyces cerevisiae S288C
Interactions: 56
UniProt ID: P16622

Gene Ontology (top 5):
GO:0004325 - ferrochelatase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0006783 - heme biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

598304

HEMH
Ferrochelatase, mitochondrial

1

1

Small-scale

0.740

High

598341

FRDA
Frataxin homolog, mitochondrial

3

0

Small-scale

0.632

High

598305

ADT2
ADP,ATP carrier protein 2

2

2

Small-scale

0.611

High

578782

HSC82
ATP-dependent molecular chaperone HSC82

2

4

High-throughput

0.584

High

598318

MIC60
MICOS complex subunit MIC60

2

0

Small-scale

0.559

High

445311

CDC31
Cell division control protein 31

2

4

Small-scale

0.533

High

598306

PWP1
Periodic tryptophan protein 1

1

1

High-throughput

0.489

High

598308

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

1

3

High-throughput

0.489

High

598321

IMB2
Importin subunit beta-2

1

2

High-throughput

0.489

High

366913

ATPB
ATP synthase subunit beta, mitochondrial

1

2

High-throughput

0.479

High

452805

ATPA
ATP synthase subunit alpha, mitochondrial

1

2

High-throughput

0.479

High

510155

HSP77
Import motor subunit, mitochondrial

1

4

High-throughput

0.479

High

598307

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

1

1

High-throughput

0.479

High

598328

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

1

High-throughput

0.479

High

598336

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

1

High-throughput

0.479

High

382822

RMAR
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.458

High

514431

RS18A
Small ribosomal subunit protein uS13A

1

0

High-throughput

0.458

High

598313

MGM1
Dynamin-like GTPase MGM1, mitochondrial

1

0

Small-scale

0.458

High

598315

TIM23
Mitochondrial import inner membrane translocase subunit TIM23

1

0

High-throughput

0.458

High

598322

MIC12
MICOS complex subunit MIC12

1

0

Small-scale

0.458

High

598325

PPOX
Protoporphyrinogen oxidase

1

0

Small-scale

0.458

High

598326

FMP10
Uncharacterized mitochondrial membrane protein FMP10

1

0

High-throughput

0.458

High

598330

MIC19
MICOS complex subunit MIC19

1

0

Small-scale

0.458

High

598332

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.458

High

598333

MIC26
MICOS subunit MIC26

1

0

Small-scale

0.458

High

598334

MIC27
MICOS complex subunit MIC27

1

0

Small-scale

0.458

High

598338

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.458

High

598340

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

0

High-throughput

0.458

High

450699

KAD2
Adenylate kinase

1

2

High-throughput

0.457

High

392174

HSP82
ATP-dependent molecular chaperone HSP82

1

4

High-throughput

0.437

High

430773

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

1

1

Small-scale

0.437

High

449055

CALM
Calmodulin

1

3

High-throughput

0.437

High

502825

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.437

High

598311

BMH1
Protein BMH1

1

1

Small-scale

0.437

High

598312

HS104
Heat shock protein 104

1

2

High-throughput

0.437

High

598316

BMH2
Protein BMH2

1

1

Small-scale

0.437

High

598337

RLI1
Translation initiation factor RLI1

1

1

Small-scale

0.437

High

598327

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.407

High

598331

NUP85
Nucleoporin NUP85

1

0

High-throughput

0.279

Low

598339

LCD1
DNA damage checkpoint protein LCD1

1

0

High-throughput

0.279

Low

598329

BNI1
Protein BNI1

1

0

High-throughput

0.261

Low

433420

RL26A
Large ribosomal subunit protein uL24A

1

0

High-throughput

0.249

Low

434793

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.249

Low

435747

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.249

Low

454847

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.249

Low

553578

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

Small-scale

0.249

Low

598309

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

598310

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

598314

TMT1
Trans-aconitate 3-methyltransferase

1

0

High-throughput

0.249

Low

598317

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.249

Low

598319

NU170
Nucleoporin NUP170

1

0

High-throughput

0.249

Low

598320

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.249

Low

598323

RPN10
26S proteasome regulatory subunit RPN10

1

0

Small-scale

0.249

Low

598324

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

598335

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025