Protein: HST2
NAD-dependent protein deacetylase HST2 (EC 2.3.1.286) (Homologous to SIR2 protein 2) (Regulatory protein SIR2 homolog 2)

Gene: HST2
Organism: Saccharomyces cerevisiae S288C
Interactions: 135
UniProt ID: P53686

Gene Ontology (top 5):
GO:0000183 - rDNA heterochromatin formation
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0016740 - transferase activity
GO:0017136 - NAD-dependent histone deacetylase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

864134

H3
Histone H3

3

10

Small-scale

0.667

High

864126

HST2
NAD-dependent protein deacetylase HST2

1

11

High-throughput

0.618

High

676248

XPO1
Exportin-1

2

8

High-throughput

0.611

High

864149

ESA1
Histone acetyltransferase ESA1

1

5

Small-scale

0.501

High

864147

RT109
Histone acetyltransferase RTT109

1

0

Small-scale

0.480

High

343300

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

6

High-throughput

0.479

High

360976

TBB
Tubulin beta chain

1

4

High-throughput

0.479

High

373477

PUR1
Amidophosphoribosyltransferase

1

4

High-throughput

0.479

High

425038

DHE4
NADP-specific glutamate dehydrogenase 1

1

3

High-throughput

0.479

High

426460

SYSC
Serine--tRNA ligase, cytoplasmic

1

2

High-throughput

0.479

High

443986

CISY2
Citrate synthase, peroxisomal

1

6

High-throughput

0.479

High

454416

TBA1
Tubulin alpha-1 chain

1

5

High-throughput

0.479

High

454643

TBA3
Tubulin alpha-3 chain

1

5

High-throughput

0.479

High

514999

RNA1
Ran GTPase-activating protein 1

1

4

High-throughput

0.479

High

527203

RPOM
DNA-directed RNA polymerase, mitochondrial

1

2

High-throughput

0.479

High

556201

VATB
V-type proton ATPase subunit B

1

5

High-throughput

0.479

High

608800

KCC2
Calcium/calmodulin-dependent protein kinase II

1

1

High-throughput

0.479

High

613135

URE2
Transcriptional regulator URE2

1

1

High-throughput

0.479

High

622179

MCM3
DNA replication licensing factor MCM3

1

12

High-throughput

0.479

High

627661

NAP1
Nucleosome assembly protein

1

4

High-throughput

0.479

High

630683

NFS1
Cysteine desulfurase, mitochondrial

1

3

High-throughput

0.479

High

657264

URA7
CTP synthase 1

1

1

High-throughput

0.479

High

662916

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

664968

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

667608

MCM2
DNA replication licensing factor MCM2

1

12

High-throughput

0.479

High

675540

MCM4
DNA replication licensing factor MCM4

1

14

High-throughput

0.479

High

686898

P5CR
Pyrroline-5-carboxylate reductase

1

3

High-throughput

0.479

High

687979

IMB3
Importin subunit beta-3

1

7

High-throughput

0.479

High

693813

CBS
Cystathionine beta-synthase

1

1

High-throughput

0.479

High

699800

KPR1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.479

High

710517

PP2C3
Protein phosphatase 2C homolog 3

1

1

High-throughput

0.479

High

715830

MDJ1
DnaJ homolog 1, mitochondrial

1

4

High-throughput

0.479

High

730999

MAOM
NAD-dependent malic enzyme, mitochondrial

1

2

High-throughput

0.479

High

733226

SA190
SIT4-associating protein SAP190

1

3

High-throughput

0.479

High

746525

IMB2
Importin subunit beta-2

1

10

High-throughput

0.479

High

751226

NCB5R
NADH-cytochrome b5 reductase 1

1

2

High-throughput

0.479

High

751249

URA8
CTP synthase 2

1

1

High-throughput

0.479

High

752948

YHI0
Putative proline--tRNA ligase YHR020W

1

2

High-throughput

0.479

High

753039

RRP3
ATP-dependent rRNA helicase RRP3

1

5

High-throughput

0.479

High

761274

CAJ1
Protein CAJ1

1

5

High-throughput

0.479

High

763439

MET10
Sulfite reductase [NADPH] flavoprotein component

1

1

High-throughput

0.479

High

765899

DLD3
D-2-hydroxyglutarate--pyruvate transhydrogenase DLD3

1

3

High-throughput

0.479

High

772427

RFC2
Replication factor C subunit 2

1

2

High-throughput

0.479

High

809805

NMD5
Nonsense-mediated mRNA decay protein 5

1

9

High-throughput

0.479

High

811411

TCPQ
T-complex protein 1 subunit theta

1

7

High-throughput

0.479

High

812593

MET5
Sulfite reductase [NADPH] subunit beta

1

1

High-throughput

0.479

High

857402

VPS4
Vacuolar protein sorting-associated protein 4

1

3

High-throughput

0.479

High

858692

PPT1
Serine/threonine-protein phosphatase T

1

7

High-throughput

0.479

High

858996

MCM6
DNA replication licensing factor MCM6

1

14

High-throughput

0.479

High

864127

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

1

High-throughput

0.479

High

864129

APJ1
J domain-containing protein APJ1

1

3

High-throughput

0.479

High

864138

ELP3
Elongator complex protein 3

1

1

High-throughput

0.479

High

864140

RUVB1
RuvB-like protein 1

1

4

High-throughput

0.479

High

864141

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

864143

HFD1
Fatty aldehyde dehydrogenase HFD1

1

8

High-throughput

0.479

High

864144

ARP9
Actin-like protein ARP9

1

2

High-throughput

0.479

High

864151

MDN1
Midasin

1

13

High-throughput

0.479

High

864152

SYWC
Tryptophan--tRNA ligase, cytoplasmic

1

1

High-throughput

0.479

High

864153

KPR5
Ribose-phosphate pyrophosphokinase 5

1

2

High-throughput

0.479

High

864154

GYP5
GTPase-activating protein GYP5

1

1

High-throughput

0.479

High

864156

RUVB2
RuvB-like protein 2

1

4

High-throughput

0.479

High

864157

YO098
Uncharacterized protein YOL098C

1

8

High-throughput

0.479

High

342479

TRPE
Anthranilate synthase component 1

1

0

High-throughput

0.458

High

440220

MET3
Sulfate adenylyltransferase

1

0

High-throughput

0.458

High

488496

PRI1
DNA primase small subunit

1

0

High-throughput

0.458

High

519614

ERF1
Eukaryotic peptide chain release factor subunit 1

1

0

High-throughput

0.458

High

549304

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.458

High

587319

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.458

High

605800

SLY1
Protein SLY1

1

0

High-throughput

0.458

High

629927

ATX10
Ataxin-10 homolog

1

0

High-throughput

0.458

High

669874

MPI
Mannose-6-phosphate isomerase

1

0

High-throughput

0.458

High

690373

DPH2
2-(3-amino-3-carboxypropyl)histidine synthase subunit 2

1

0

High-throughput

0.458

High

706946

HIS5
Imidazole glycerol phosphate synthase hisHF

1

0

High-throughput

0.458

High

754394

PANE
2-dehydropantoate 2-reductase

1

0

High-throughput

0.458

High

758955

LYS9
Saccharopine dehydrogenase [NADP(+), L-glutamate-forming]

1

0

High-throughput

0.458

High

759197

GDS1
GTPase-GDP dissociation stimulator BEM4

1

0

High-throughput

0.458

High

797173

GYP8
GTPase-activating protein GYP8

1

0

High-throughput

0.458

High

812004

GPN1
GPN-loop GTPase 1

1

0

High-throughput

0.458

High

817362

HGH1
Protein HGH1

1

0

High-throughput

0.458

High

858516

TEL2
Telomere length regulation protein TEL2

1

0

High-throughput

0.458

High

861339

ZPR1
Zinc finger chaperone ZPR1

1

0

High-throughput

0.458

High

864133

ERG13
Hydroxymethylglutaryl-CoA synthase

1

0

High-throughput

0.458

High

864135

TPS1
Alpha,alpha-trehalose-phosphate synthase [UDP-forming] 56 kDa subunit

1

0

High-throughput

0.458

High

864137

FMP30
N-acyl-phosphatidylethanolamine-hydrolyzing phospholipase D, mitochondrial

1

0

High-throughput

0.458

High

864139

RMT2
Protein arginine N-methyltransferase 2

1

0

High-throughput

0.458

High

864148

ETT1
Enhancer of translation termination 1

1

0

High-throughput

0.458

High

864150

ETFD
Probable electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial

1

0

High-throughput

0.458

High

864155

DPH6
Diphthine--ammonia ligase

1

0

High-throughput

0.458

High

512197

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.445

High

695211

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

766139

HSP7E
Heat shock protein SSC3, mitochondrial

1

15

High-throughput

0.445

High

769057

SSB2
Ribosome-associated molecular chaperone SSB2

1

14

High-throughput

0.445

High

342075

ATPB
ATP synthase subunit beta, mitochondrial

1

4

High-throughput

0.437

High

343137

THDH
Threonine dehydratase, mitochondrial

1

1

High-throughput

0.437

High

423034

TOM70
Mitochondrial import receptor subunit TOM70

1

1

High-throughput

0.437

High

423886

ATPA
ATP synthase subunit alpha, mitochondrial

1

5

High-throughput

0.437

High

452559

KEX1
Pheromone-processing carboxypeptidase KEX1

1

1

High-throughput

0.437

High

456747

HEM1
5-aminolevulinate synthase, mitochondrial

1

2

High-throughput

0.437

High

532799

ACOX
Acyl-coenzyme A oxidase

1

5

High-throughput

0.437

High

588176

HSP60
Heat shock protein 60, mitochondrial

1

8

High-throughput

0.437

High

598677

OSM1
Fumarate reductase 2

1

2

High-throughput

0.437

High

626003

SPTC1
Serine palmitoyltransferase 1

1

2

High-throughput

0.437

High

688046

NDI1
Rotenone-insensitive NADH-ubiquinone oxidoreductase, mitochondrial

1

2

High-throughput

0.437

High

690751

EUG1
Protein disulfide-isomerase EUG1

1

3

High-throughput

0.437

High

733390

CAF4
CCR4-associated factor 4

1

6

High-throughput

0.437

High

744109

ATG42
Vacuolar serine-type carboxypeptidase ATG42

1

1

High-throughput

0.437

High

748458

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

5

High-throughput

0.437

High

751198

GUAA
GMP synthase [glutamine-hydrolyzing]

1

6

High-throughput

0.437

High

760918

TCPD
T-complex protein 1 subunit delta

1

5

High-throughput

0.437

High

765806

VAC8
Vacuolar protein 8

1

12

High-throughput

0.437

High

767292

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

7

High-throughput

0.437

High

775510

EPS1
ER-retained PMA1-suppressing protein 1

1

3

High-throughput

0.437

High

803403

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

7

High-throughput

0.437

High

811953

ARP3
Actin-related protein 3

1

2

High-throughput

0.437

High

819927

MON2
Protein MON2

1

1

High-throughput

0.437

High

864131

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

7

High-throughput

0.437

High

864145

SGPL
Sphingosine-1-phosphate lyase

1

3

High-throughput

0.437

High

495857

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.249

Low

521021

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.249

Low

592956

SRP54
Signal recognition particle subunit SRP54

1

0

High-throughput

0.249

Low

634295

MGR1
Mitochondrial inner membrane i-AAA protease supercomplex subunit MGR1

1

0

High-throughput

0.249

Low

682245

OCH1
Initiation-specific alpha-1,6-mannosyltransferase

1

0

High-throughput

0.249

Low

690790

ERG1
Squalene epoxidase ERG1

1

0

High-throughput

0.249

Low

732949

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.249

Low

766400

GEA2
ARF guanine-nucleotide exchange factor 2

1

0

High-throughput

0.249

Low

783535

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.249

Low

823321

GPI8
GPI-anchor transamidase

1

0

High-throughput

0.249

Low

861450

COQ6
Ubiquinone biosynthesis monooxygenase COQ6, mitochondrial

1

0

High-throughput

0.249

Low

864128

YNT3
Uncharacterized protein YNL193W

1

0

High-throughput

0.249

Low

864130

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

864132

ERG5
C-22 sterol desaturase ERG5

1

0

High-throughput

0.249

Low

864136

ARG56
Protein ARG5,6, mitochondrial [Cleaved into: N-acetyl-gamma-glutamyl-phosphate reductase

1

0

High-throughput

0.249

Low

864142

GPI17
GPI transamidase component GPI17

1

0

High-throughput

0.249

Low

864146

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024