Protein: HEM1
5-aminolevulinate synthase, mitochondrial (EC 2.3.1.37) (5-aminolevulinic acid synthase) (Delta-ALA synthase) (Delta-aminolevulinate synthase)

Gene: HEM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 24
UniProt ID: P09950

Gene Ontology (top 5):
GO:0003870 - 5-aminolevulinate synthase activity
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0006782 - protoporphyrinogen IX biosynthetic process
GO:0006783 - heme biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

488645

HEM1
5-aminolevulinate synthase, mitochondrial

1

10

High-throughput

0.618

High

488646

HSP77
Import motor subunit, mitochondrial

2

2

High-throughput

0.584

High

488658

CLPX
ATP-dependent clpX-like chaperone, mitochondrial

1

1

Small-scale

0.561

High

382791

RMAR
Small ribosomal subunit protein uS3m

1

1

High-throughput

0.479

High

488655

PREP
Presequence protease, mitochondrial

1

2

High-throughput

0.479

High

488656

HSP78
Heat shock protein 78, mitochondrial

1

2

High-throughput

0.479

High

488657

LONM
Lon protease homolog, mitochondrial

1

2

High-throughput

0.479

High

488653

COQ8
Atypical kinase COQ8, mitochondrial

1

0

High-throughput

0.458

High

488661

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

488648

HSP72
Heat shock protein SSA2

1

4

High-throughput

0.445

High

488650

HSP60
Heat shock protein 60, mitochondrial

1

4

High-throughput

0.445

High

488651

SIS1
Protein SIS1

1

2

High-throughput

0.437

High

488654

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

488660

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

488663

HST2
NAD-dependent protein deacetylase HST2

1

2

High-throughput

0.437

High

488664

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.437

High

488659

SSZ1
Ribosome-associated complex subunit SSZ1

1

3

High-throughput

0.407

High

488662

MPG1
Mannose-1-phosphate guanyltransferase

1

1

High-throughput

0.407

High

460933

LTE1
Guanine nucleotide exchange factor LTE1

1

0

High-throughput

0.279

Low

488647

SSBP1
Single-stranded nucleic acid-binding protein

1

0

High-throughput

0.261

Low

488649

IF5A2
Eukaryotic translation initiation factor 5A-2

1

0

High-throughput

0.249

Low

488652

SPB4
ATP-dependent rRNA helicase SPB4

1

0

High-throughput

0.249

Low

488665

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025