Protein: PREP
Presequence protease, mitochondrial (PreP) (EC 3.4.24.-) (Metalloprotease of 112 kDa) (Pitrilysin metalloproteinase) (Protease M)

Gene: PREP, CYM1
Organism: Saccharomyces cerevisiae S288C
Interactions: 46
UniProt ID: P32898

Gene Ontology (top 5):
GO:0004176 - ATP-dependent peptidase activity
GO:0004222 - metalloendopeptidase activity
GO:0005739 - mitochondrion
GO:0005758 - mitochondrial intermembrane space
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

484746

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

3

1

High-throughput

0.662

High

594916

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, mitochondrial

3

12

High-throughput

0.662

High

737442

ODPB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

3

3

High-throughput

0.662

High

554900

ODP2
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

2

9

High-throughput

0.621

High

596806

ODPX
Pyruvate dehydrogenase complex protein X component, mitochondrial

2

10

High-throughput

0.621

High

510337

HSP77
Import motor subunit, mitochondrial

2

7

High-throughput

0.584

High

604932

MDHM
Malate dehydrogenase, mitochondrial

2

5

Small-scale

0.584

High

746990

GRPE
GrpE protein homolog, mitochondrial

2

3

High-throughput

0.571

High

361477

SODM
Superoxide dismutase [Mn], mitochondrial

1

1

High-throughput

0.479

High

366984

ATPB
ATP synthase subunit beta, mitochondrial

1

11

High-throughput

0.479

High

399813

COX4
Cytochrome c oxidase subunit 4, mitochondrial

1

1

High-throughput

0.479

High

452649

ADH3
Alcohol dehydrogenase 3, mitochondrial

1

1

High-throughput

0.479

High

488655

HEM1
5-aminolevulinate synthase, mitochondrial

1

2

High-throughput

0.479

High

622344

ACON
Aconitate hydratase, mitochondrial

1

3

High-throughput

0.479

High

626668

HSP60
Heat shock protein 60, mitochondrial

1

7

High-throughput

0.479

High

642132

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

1

High-throughput

0.479

High

673327

TRX3
Thioredoxin-3, mitochondrial

1

1

High-throughput

0.479

High

673487

STDH
Catabolic L-serine/threonine dehydratase [Includes: L-serine dehydratase

1

1

High-throughput

0.479

High

685100

KAD3
GTP:AMP phosphotransferase, mitochondrial

1

2

High-throughput

0.479

High

694466

COQ3
Ubiquinone biosynthesis O-methyltransferase, mitochondrial

1

2

High-throughput

0.479

High

701501

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

4

High-throughput

0.479

High

705750

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

4

High-throughput

0.479

High

746989

HSP78
Heat shock protein 78, mitochondrial

1

1

High-throughput

0.479

High

746993

ALDH5
Aldehyde dehydrogenase 5, mitochondrial

1

4

High-throughput

0.479

High

746995

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

5

High-throughput

0.479

High

746996

ETFB
Probable electron transfer flavoprotein subunit beta

1

3

High-throughput

0.479

High

746998

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

4

High-throughput

0.479

High

747002

COX20
Cytochrome c oxidase assembly protein COX20, mitochondrial

1

2

High-throughput

0.479

High

747004

ISD11
Protein ISD11

1

4

High-throughput

0.479

High

439112

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.458

High

456370

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

0

High-throughput

0.458

High

654591

AIM17
Probable oxidoreductase AIM17

1

0

High-throughput

0.458

High

677795

ILV6
Acetolactate synthase small subunit, mitochondrial

1

0

High-throughput

0.458

High

746992

ILV3
Dihydroxy-acid dehydratase, mitochondrial

1

0

High-throughput

0.458

High

746999

GCSP
Glycine dehydrogenase

1

0

High-throughput

0.458

High

747000

GLRX5
Monothiol glutaredoxin-5, mitochondrial

1

0

High-throughput

0.458

High

675850

MAS5
Mitochondrial protein import protein MAS5

1

5

High-throughput

0.445

High

746988

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.437

High

747001

SCC2
Sister chromatid cohesion protein 2

1

3

High-throughput

0.437

High

544286

SSB1
Ribosome-associated molecular chaperone SSB1

1

7

High-throughput

0.407

High

746991

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.407

High

746994

JEM1
DnaJ-like chaperone JEM1

1

3

High-throughput

0.407

High

746997

ERJ5
ER-localized J domain-containing protein 5

1

6

High-throughput

0.407

High

747003

HSP42
Heat shock protein 42

2

0

High-throughput

0.324

High

64233

YP010
UPF0495 protein YPR010C-A

1

0

Small-scale

0.249

Low

531668

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025