Protein: GDF15
Growth/differentiation factor 15 (GDF-15) (Macrophage inhibitory cytokine 1) (MIC-1) (NSAID-activated gene 1 protein) (NAG-1) (NSAID-regulated gene 1 protein) (NRG-1) (Placental TGF-beta) (Placental bone morphogenetic protein) (Prostate differentiation factor)

Gene: GDF15
Organism: Homo sapiens
Interactions: 71
UniProt ID: Q99988

Gene Ontology (top 5):
GO:0002023 - reduction of food intake in response to dietary excess
GO:0002686 - negative regulation of leukocyte migration
GO:0005125 - cytokine activity
GO:0005179 - hormone activity
GO:0005576 - extracellular region

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1307540

GDF15
Growth/differentiation factor 15

3

17

Small-scale

0.834

High

1166763

GFRAL
GDNF family receptor alpha-like

1

1

Small-scale

0.692

High

155769

GDF8
Growth/differentiation factor 8

1

16

High-throughput

0.691

High

265791

CRLF1
Cytokine receptor-like factor 1

1

2

High-throughput

0.691

High

1269016

SORL
Sortilin-related receptor

1

2

High-throughput

0.691

High

1301435

ERBIN
Erbin

1

1

High-throughput

0.691

High

1306221

MDFI
MyoD family inhibitor

3

0

High-throughput

0.643

High

829987

HXA1
Homeobox protein Hox-A1

2

5

High-throughput

0.606

High

1307553

TACC3
Transforming acidic coiled-coil-containing protein 3

2

1

High-throughput

0.606

High

1307545

RMD5A
E3 ubiquitin-protein transferase RMND5A

2

6

High-throughput

0.601

High

1027220

CBX3
Chromobox protein homolog 3

2

0

High-throughput

0.580

High

1081583

NTRK3
NT-3 growth factor receptor

1

1

High-throughput

0.578

High

1068500

KPCD1
Serine/threonine-protein kinase D1

2

1

High-throughput

0.571

High

887415

KR122
Keratin-associated protein 12-2

2

14

High-throughput

0.553

High

408669

KPCB
Protein kinase C beta type

2

0

High-throughput

0.547

High

204037

HTRA2
Serine protease HTRA2, mitochondrial

1

6

High-throughput

0.536

High

211396

PI15
Peptidase inhibitor 15

1

1

High-throughput

0.536

High

319631

LY86
Lymphocyte antigen 86

1

2

High-throughput

0.536

High

445255

CEL3B
Chymotrypsin-like elastase family member 3B

1

3

High-throughput

0.536

High

474769

CFC1
Cryptic protein

1

12

High-throughput

0.536

High

502476

BIP
Endoplasmic reticulum chaperone BiP

1

5

High-throughput

0.536

High

533056

PRG2
Bone marrow proteoglycan

1

5

High-throughput

0.536

High

557236

PGFRA
Platelet-derived growth factor receptor alpha

1

6

High-throughput

0.536

High

571201

EGLN
Endoglin

1

9

High-throughput

0.536

High

657892

CYTD
Cystatin-D

1

2

High-throughput

0.536

High

786634

STA5A
Signal transducer and activator of transcription 5A

1

1

High-throughput

0.536

High

873742

SLUR1
Secreted Ly-6/uPAR-related protein 1

1

3

High-throughput

0.536

High

964690

IL5RA
Interleukin-5 receptor subunit alpha

1

5

High-throughput

0.536

High

1016019

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

7

High-throughput

0.536

High

1044424

PTC1
Protein patched homolog 1

1

3

High-throughput

0.536

High

1167170

RBP10
Ran-binding protein 10

1

8

High-throughput

0.536

High

1185143

MAEA
E3 ubiquitin-protein transferase MAEA

1

7

High-throughput

0.536

High

1238428

TM102
Transmembrane protein 102

1

1

High-throughput

0.536

High

1262426

CA054
Uncharacterized protein C1orf54

1

3

High-throughput

0.536

High

1283141

T106A
Transmembrane protein 106A

1

1

High-throughput

0.536

High

1291935

RMD5B
E3 ubiquitin-protein transferase RMND5B

1

6

High-throughput

0.536

High

1300433

RAB3I
Rab-3A-interacting protein

1

2

High-throughput

0.536

High

1301766

RANB9
Ran-binding protein 9

1

8

High-throughput

0.536

High

1307544

WDR26
WD repeat-containing protein 26

1

6

High-throughput

0.536

High

1307547

GID8
Glucose-induced degradation protein 8 homolog

1

7

High-throughput

0.536

High

1307551

MKLN1
Muskelin

1

1

High-throughput

0.536

High

1307552

PRG3
Proteoglycan 3

1

6

High-throughput

0.536

High

344005

ASSY
Argininosuccinate synthase

1

0

High-throughput

0.513

High

387396

P53
Cellular tumor antigen p53

1

0

High-throughput

0.513

High

914886

YPEL5
Protein yippee-like 5

1

0

High-throughput

0.513

High

990268

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.513

High

1049439

MORC3
MORC family CW-type zinc finger protein 3

1

0

High-throughput

0.513

High

1216820

ARMC8
Armadillo repeat-containing protein 8

1

0

High-throughput

0.513

High

1289204

ZMY19
Zinc finger MYND domain-containing protein 19

1

0

High-throughput

0.513

High

1307546

SETD4
SET domain-containing protein 4

1

0

High-throughput

0.513

High

1307549

SAE1
SUMO-activating enzyme subunit 1

1

0

High-throughput

0.513

High

1307550

TCAL9
Transcription elongation factor A protein-like 9

1

0

High-throughput

0.513

High

1263136

OIT3
Oncoprotein-induced transcript 3 protein

1

15

High-throughput

0.489

High

1307541

NUP58
Nucleoporin p58/p45

1

2

High-throughput

0.489

High

1082622

MK14
Mitogen-activated protein kinase 14

1

0

High-throughput

0.486

High

374765

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.479

High

487718

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

903468

WDR5
WD repeat-containing protein 5

1

4

High-throughput

0.479

High

959634

VIGLN
Vigilin

1

2

High-throughput

0.479

High

1036850

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

1261406

NUDC2
NudC domain-containing protein 2

1

1

High-throughput

0.479

High

968645

TAGL
Transgelin

1

0

High-throughput

0.426

High

63798

CC85C
Coiled-coil domain-containing protein 85C

1

0

High-throughput

0.279

Low

678057

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

1218035

GID4
Glucose-induced degradation protein 4 homolog

1

0

High-throughput

0.279

Low

1234991

RM50
Large ribosomal subunit protein mL50

1

0

High-throughput

0.279

Low

1303658

GML
Glycosyl-phosphatidylinositol-anchored molecule-like protein

1

0

High-throughput

0.279

Low

1307542

CHST8
Carbohydrate sulfotransferase 8

1

0

High-throughput

0.279

Low

1307543

DPEP2
Dipeptidase 2

1

0

High-throughput

0.279

Low

1307548

NLGN3
Neuroligin-3

1

0

Small-scale

0.265

Low


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Last updated: 15 Jul 2024