Protein: PP11
Serine/threonine-protein phosphatase PP1-1 (EC 3.1.3.16)

Gene: PP11, SIT4
Organism: Saccharomyces cerevisiae S288C
Interactions: 130
UniProt ID: P20604

Gene Ontology (top 5):
GO:0000082 - G1/S transition of mitotic cell cycle
GO:0000159 - protein phosphatase type 2A complex
GO:0002098 - tRNA wobble uridine modification
GO:0004722 - protein serine/threonine phosphatase activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

633509

TAP42
Type 2A phosphatase-associated protein 42

10

20

Small-scale

0.975

High

633475

PTPA1
Serine/threonine-protein phosphatase 2A activator 1

6

11

Small-scale

0.941

High

633481

SA155
SIT4-associating protein SAP155

11

8

Small-scale

0.759

High

633478

SA185
SIT4-associating protein SAP185

10

8

Small-scale

0.756

High

633522

PTPA2
Serine/threonine-protein phosphatase 2A activator 2

2

11

Small-scale

0.754

High

633458

SA190
SIT4-associating protein SAP190

8

8

Small-scale

0.753

High

633501

ACAC
Acetyl-CoA carboxylase

4

5

High-throughput

0.699

High

633466

TCPB
T-complex protein 1 subunit beta

4

20

High-throughput

0.697

High

633437

PP11
Serine/threonine-protein phosphatase PP1-1

1

13

High-throughput

0.665

High

633445

HRR25
Casein kinase I homolog HRR25

2

16

Small-scale

0.639

High

633492

MDS3
Negative regulator of sporulation MDS3

3

0

Small-scale

0.634

High

543792

SSB1
Ribosome-associated molecular chaperone SSB1

3

15

High-throughput

0.633

High

633495

RTS3
Protein phosphatase type 2A regulatory subunit RTS3

2

1

High-throughput

0.628

High

633471

BEM2
GTPase-activating protein BEM2/IPL2

2

5

High-throughput

0.621

High

633516

HRK1
Serine/threonine-protein kinase HRK1

2

11

High-throughput

0.621

High

633451

ARP2
Actin-related protein 2

1

8

High-throughput

0.618

High

632856

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

4

Small-scale

0.618

High

633479

TCPH
T-complex protein 1 subunit eta

2

20

High-throughput

0.611

High

633469

TCPZ
T-complex protein 1 subunit zeta

3

20

High-throughput

0.609

High

416859

CDC25
Cell division control protein 25

2

0

High-throughput

0.595

High

633483

TCPQ
T-complex protein 1 subunit theta

2

20

High-throughput

0.594

High

553941

TCPA
T-complex protein 1 subunit alpha

3

20

High-throughput

0.593

High

633513

ELP1
Elongator complex protein 1

2

0

Small-scale

0.588

High

592006

VATB
V-type proton ATPase subunit B

2

2

High-throughput

0.584

High

633455

FAB1
1-phosphatidylinositol 3-phosphate 5-kinase FAB1

2

20

High-throughput

0.567

High

633491

DXO
Decapping nuclease RAI1

2

0

High-throughput

0.563

High

633498

SWT21
Protein SWT21

2

0

High-throughput

0.563

High

633514

DTD
D-aminoacyl-tRNA deacylase

2

0

High-throughput

0.563

High

633467

TCPG
T-complex protein 1 subunit gamma

2

20

High-throughput

0.558

High

633468

TCPD
T-complex protein 1 subunit delta

2

20

High-throughput

0.558

High

633480

ATG18
Autophagy-related protein 18

2

3

Small-scale

0.558

High

510184

HSP77
Import motor subunit, mitochondrial

2

20

High-throughput

0.552

High

523036

HSP71
Heat shock protein SSA1

2

14

High-throughput

0.552

High

525901

HSP72
Heat shock protein SSA2

2

14

High-throughput

0.552

High

633452

HSP7F
Heat shock protein homolog SSE1

2

19

High-throughput

0.552

High

633472

SSB2
Ribosome-associated molecular chaperone SSB2

2

15

High-throughput

0.552

High

598949

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

4

High-throughput

0.536

High

633440

CDC15
Cell division control protein 15

1

20

High-throughput

0.536

High

633448

XPO1
Exportin-1

1

5

High-throughput

0.536

High

633453

TOR2
Serine/threonine-protein kinase TOR2

1

11

Small-scale

0.536

High

633484

GPN1
GPN-loop GTPase 1

1

1

High-throughput

0.536

High

633485

ADK
Adenosine kinase

1

1

High-throughput

0.536

High

633486

SSN8
RNA polymerase II holoenzyme cyclin-like subunit

1

7

High-throughput

0.536

High

633487

LCF4
Long-chain-fatty-acid--CoA ligase 4

1

1

High-throughput

0.536

High

633493

SGF73
SAGA complex subunit SGF73

1

1

High-throughput

0.536

High

633496

PRS10
26S proteasome subunit RPT4

1

12

High-throughput

0.536

High

633500

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

9

High-throughput

0.536

High

633507

CTK1
CTD kinase subunit alpha

1

12

High-throughput

0.536

High

633524

RL11B
Large ribosomal subunit protein uL5B

1

2

High-throughput

0.536

High

633441

GAC1
Serine/threonine-protein phosphatase 1 regulatory subunit GAC1

1

15

Small-scale

0.528

High

633461

SDS24
Protein SDS24

1

5

High-throughput

0.515

High

633462

RCK2
Serine/threonine-protein kinase RCK2

1

15

High-throughput

0.515

High

488588

RIR2
Ribonucleoside-diphosphate reductase small chain 1

1

0

High-throughput

0.513

High

625937

UBR1
E3 ubiquitin-protein ligase UBR1

1

0

High-throughput

0.513

High

633456

MAOM
NAD-dependent malic enzyme, mitochondrial

1

0

High-throughput

0.513

High

633503

DIG1
Down-regulator of invasive growth 1

1

0

High-throughput

0.513

High

633504

RMT2
Protein arginine N-methyltransferase 2

1

0

High-throughput

0.513

High

633508

YM54
Uncharacterized protein YMR196W

1

0

High-throughput

0.513

High

633510

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.513

High

509390

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

15

High-throughput

0.501

High

367692

ENO1
Enolase 1

1

1

High-throughput

0.500

High

386562

TBB
Tubulin beta chain

1

6

High-throughput

0.500

High

399343

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

3

High-throughput

0.500

High

416368

HXKA
Hexokinase-1

1

1

High-throughput

0.500

High

439240

PDC1
Pyruvate decarboxylase isozyme 1

1

1

High-throughput

0.500

High

470022

GAL7
Galactose-1-phosphate uridylyltransferase

1

1

High-throughput

0.500

High

481477

HSP73
Heat shock protein SSA3

1

14

High-throughput

0.500

High

486404

TBA3
Tubulin alpha-3 chain

1

8

High-throughput

0.500

High

538321

PYC1
Pyruvate carboxylase 1

1

4

High-throughput

0.500

High

590525

HSP26
Heat shock protein 26

1

2

High-throughput

0.500

High

597032

BIP
Endoplasmic reticulum chaperone BiP

1

15

High-throughput

0.500

High

598807

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

4

High-throughput

0.500

High

633438

MAS5
Mitochondrial protein import protein MAS5

1

3

High-throughput

0.500

High

633439

CDC48
Cell division control protein 48

1

7

High-throughput

0.500

High

633446

BMH1
Protein BMH1

1

4

High-throughput

0.500

High

633454

PRS6B
26S proteasome regulatory subunit 6B homolog

1

4

High-throughput

0.500

High

633470

SAHH
Adenosylhomocysteinase

1

1

High-throughput

0.500

High

633506

RUVB1
RuvB-like protein 1

1

8

High-throughput

0.500

High

633519

HSP42
Heat shock protein 42

1

2

High-throughput

0.500

High

633520

HRT3
F-box protein HRT3

1

0

High-throughput

0.493

High

633464

SFB3
SED5-binding protein 3

1

2

Small-scale

0.489

High

633465

SEC31
Protein transport protein SEC31

1

12

Small-scale

0.489

High

633447

LCF1
Long-chain-fatty-acid--CoA ligase 1

1

1

High-throughput

0.489

High

633473

NDH1
External NADH-ubiquinone oxidoreductase 1, mitochondrial

1

4

High-throughput

0.489

High

633523

GLT1
Glutamate synthase [NADH]

1

3

High-throughput

0.489

High

408286

GAL1
Galactokinase

1

0

High-throughput

0.479

High

439087

ILV5
Ketol-acid reductoisomerase, mitochondrial

1

0

High-throughput

0.479

High

454076

DHE4
NADP-specific glutamate dehydrogenase 1

1

0

High-throughput

0.479

High

531241

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.479

High

572513

ALF
Fructose-bisphosphate aldolase

1

0

High-throughput

0.479

High

633442

URA7
CTP synthase 1

1

0

High-throughput

0.479

High

401884

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

5

Small-scale

0.479

High

448641

SNF1
Carbon catabolite-derepressing protein kinase

1

6

Small-scale

0.479

High

633444

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.479

High

633450

KNS1
Dual specificity protein kinase KNS1

1

11

Small-scale

0.479

High

633490

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

2

High-throughput

0.479

High

633494

SDS23
Protein SDS23

1

5

High-throughput

0.479

High

633497

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

633502

XRN2
5'-3' exoribonuclease 2

1

1

High-throughput

0.479

High

633512

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

1

High-throughput

0.479

High

633518

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

633517

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.458

High

582409

SEC23
Protein transport protein SEC23

1

1

Small-scale

0.457

High

633476

SEC24
Protein transport protein SEC24

1

2

Small-scale

0.457

High

633515

TLG2
t-SNARE affecting a late Golgi compartment protein 2

1

4

Small-scale

0.457

High

405025

LEU3
3-isopropylmalate dehydrogenase

1

3

High-throughput

0.457

High

456328

ILVB
Acetolactate synthase catalytic subunit, mitochondrial

1

1

High-throughput

0.457

High

603405

VATA
V-type proton ATPase catalytic subunit A

1

3

High-throughput

0.457

High

626578

HSP60
Heat shock protein 60, mitochondrial

1

14

High-throughput

0.457

High

633443

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

2

High-throughput

0.457

High

633477

LYS12
Homoisocitrate dehydrogenase, mitochondrial

1

3

High-throughput

0.457

High

633482

ALDH4
Potassium-activated aldehyde dehydrogenase, mitochondrial

1

1

High-throughput

0.457

High

633499

ALDH6
Magnesium-activated aldehyde dehydrogenase, cytosolic

1

1

High-throughput

0.457

High

394232

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

633511

HSP7Q
Iron-sulfur cluster biogenesis chaperone, mitochondrial

1

20

High-throughput

0.445

High

366923

ATPB
ATP synthase subunit beta, mitochondrial

1

2

Small-scale

0.437

High

633474

TCPE
T-complex protein 1 subunit epsilon

1

20

High-throughput

0.437

High

633521

DBP10
ATP-dependent RNA helicase DBP10

1

6

High-throughput

0.437

High

409933

RL25
Large ribosomal subunit protein uL23

1

1

High-throughput

0.407

High

633488

HLJ1
Protein HLJ1

1

3

High-throughput

0.407

High

633459

RM03
Large ribosomal subunit protein mL44

3

0

High-throughput

0.345

High

633457

MIA40
Mitochondrial intermembrane space import and assembly protein 40

3

0

High-throughput

0.335

High

633489

AVT4
Vacuolar amino acid transporter 4

2

0

High-throughput

0.307

High

585528

BGL2
Glucan 1,3-beta-glucosidase

1

0

High-throughput

0.279

Low

633449

VATC
V-type proton ATPase subunit C

1

0

High-throughput

0.279

Low

633460

ATPG
ATP synthase subunit gamma, mitochondrial

1

0

High-throughput

0.279

Low

633463

HXT5
Probable glucose transporter HXT5

1

0

High-throughput

0.279

Low

633505

TLG1
t-SNARE affecting a late Golgi compartment protein 1

1

0

Small-scale

0.261

Low

408553

GAL10
Bifunctional protein GAL10 [Includes: UDP-glucose 4-epimerase

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025