Protein: MTHR2
Methylenetetrahydrofolate reductase 2 (EC 1.5.1.53) (YmL45)

Gene: MTHR2, MET13
Organism: Saccharomyces cerevisiae S288C
Interactions: 25
UniProt ID: P53128

Gene Ontology (top 5):
GO:0004489 - methylenetetrahydrofolate reductase [NAD(P)H] activity
GO:0005739 - mitochondrion
GO:0009086 - methionine biosynthetic process
GO:0035999 - tetrahydrofolate interconversion
GO:0071949 - FAD binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

856206

MTHR1
Methylenetetrahydrofolate reductase 1

3

2

Small-scale

0.848

High

917419

METX
Putative cystathionine gamma-synthase YML082W

2

1

High-throughput

0.571

High

806319

KOG1
Target of rapamycin complex 1 subunit KOG1

1

1

High-throughput

0.552

High

850108

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

1

1

High-throughput

0.479

High

917421

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.458

High

509652

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

1

High-throughput

0.457

High

527224

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

464621

PBS2
MAP kinase kinase PBS2

1

1

High-throughput

0.437

High

670941

SIS1
Protein SIS1

1

3

High-throughput

0.437

High

707690

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

524611

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.407

High

545624

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.407

High

676183

MAS5
Mitochondrial protein import protein MAS5

1

2

High-throughput

0.407

High

742014

HSP7F
Heat shock protein homolog SSE1

1

5

High-throughput

0.407

High

819311

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.407

High

623903

MYO2
Myosin-2

1

0

Small-scale

0.251

Low

400071

PUR1
Amidophosphoribosyltransferase

1

0

High-throughput

0.249

Low

416266

SYDC
Aspartate--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

632910

IF2A
Eukaryotic translation initiation factor 2 subunit alpha

1

0

High-throughput

0.249

Low

737914

HOG1
Mitogen-activated protein kinase HOG1

1

0

High-throughput

0.249

Low

796735

TTL
Probable tubulin--tyrosine ligase PBY1

1

0

High-throughput

0.249

Low

898941

PHO23
Transcriptional regulatory protein PHO23

1

0

High-throughput

0.249

Low

917420

NKP2
Inner kinetochore subunit NKP2

1

0

High-throughput

0.249

Low

830009

LYS14
Lysine biosynthesis regulatory protein LYS14

1

0

High-throughput

0.238

Low

917422

HSP42
Heat shock protein 42

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025