Protein: SWE1
Mitosis inhibitor protein kinase SWE1 (EC 2.7.11.1) (Wee1 homolog)

Gene: SWE1
Organism: Saccharomyces cerevisiae S288C
Interactions: 165
UniProt ID: P32944

Gene Ontology (top 5):
GO:0000086 - G2/M transition of mitotic cell cycle
GO:0000320 - re-entry into mitotic cell cycle
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004713 - protein tyrosine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

364440

CDK1
Cyclin-dependent kinase 1

9

19

Small-scale

0.980

High

667079

CG22
G2/mitotic-specific cyclin-2

6

11

Small-scale

0.948

High

739940

CDC5
Cell cycle serine/threonine-protein kinase CDC5/MSD2

6

19

Small-scale

0.945

High

633243

CKS1
Cyclin-dependent kinases regulatory subunit

2

3

Small-scale

0.799

High

748891

CDC14
Tyrosine-protein phosphatase CDC14

2

6

Small-scale

0.789

High

392477

HSP82
ATP-dependent molecular chaperone HSP82

2

20

Small-scale

0.768

High

748828

HSL7
Protein arginine N-methyltransferase HSL7

7

1

Small-scale

0.755

High

445329

CDC31
Cell division control protein 31

1

7

High-throughput

0.691

High

449100

CALM
Calmodulin

1

4

High-throughput

0.691

High

560597

KIN1
Serine/threonine protein kinase KIN1

1

20

High-throughput

0.691

High

560670

KIN2
Serine/threonine-protein kinase KIN2

1

20

High-throughput

0.691

High

622906

CSK22
Casein kinase II subunit alpha'

1

20

High-throughput

0.691

High

748862

CSK2B
Casein kinase II subunit beta

1

8

High-throughput

0.691

High

748876

MLC1
Myosin light chain 1

1

4

High-throughput

0.691

High

673692

KCC4
Probable serine/threonine-protein kinase KCC4

1

20

Small-scale

0.681

High

376183

RAS1
Ras-like protein 1

1

20

High-throughput

0.647

High

509885

RL40A
Ubiquitin-ribosomal protein eL40A fusion protein [Cleaved into: Ubiquitin; Large ribosomal subunit protein eL40A

1

11

High-throughput

0.647

High

692545

NSR1
Nuclear localization sequence-binding protein

1

16

High-throughput

0.647

High

748817

EDE1
EH domain-containing and endocytosis protein 1

1

20

High-throughput

0.647

High

748826

YPT10
GTP-binding protein YPT10

1

10

High-throughput

0.647

High

748832

RIM4
Meiotic activator RIM4

1

15

High-throughput

0.647

High

748870

CLA4
Serine/threonine-protein kinase CLA4

1

19

Small-scale

0.647

High

748875

MIG2
Regulatory protein MIG2

1

8

High-throughput

0.647

High

748885

JJJ1
J protein JJJ1

1

20

High-throughput

0.647

High

748889

CRZ1
Transcriptional regulator CRZ1

1

5

High-throughput

0.647

High

748895

GAL83
SNF1 protein kinase subunit beta-3

1

1

High-throughput

0.647

High

748915

ENV7
Serine/threonine-protein kinase ENV7

1

17

High-throughput

0.647

High

748922

ARP8
Actin-like protein ARP8

1

11

High-throughput

0.647

High

748840

KEL1
Kelch repeat-containing protein 1

2

12

High-throughput

0.628

High

646011

KIN3
Serine/threonine-protein kinase KIN3

1

20

High-throughput

0.621

High

734596

NUD1
Protein NUD1

1

20

Small-scale

0.621

High

748836

UBA4
Adenylyltransferase and sulfurtransferase UBA4

1

4

High-throughput

0.621

High

660780

PP2A1
Serine/threonine-protein phosphatase PP2A-1 catalytic subunit

2

20

Small-scale

0.619

High

660843

PP2A2
Serine/threonine-protein phosphatase PP2A-2 catalytic subunit

2

20

Small-scale

0.619

High

694188

BUD14
Bud site selection protein 14

2

2

High-throughput

0.619

High

748823

SPC42
Spindle pole body component SPC42

2

1

High-throughput

0.619

High

475114

CYAA
Adenylate cyclase

1

20

High-throughput

0.618

High

579109

HSC82
ATP-dependent molecular chaperone HSC82

1

20

Small-scale

0.618

High

748868

BUD4
Bud site selection protein 4

1

0

High-throughput

0.614

High

574787

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

2

5

Small-scale

0.602

High

542955

CDC24
Cell division control protein 24

2

14

High-throughput

0.590

High

711486

BEM1
Bud emergence protein 1

2

20

High-throughput

0.590

High

662083

MPIP
M-phase inducer phosphatase

1

0

Small-scale

0.586

High

748908

DIB1
Spliceosomal protein DIB1

2

0

High-throughput

0.579

High

577076

SEC63
Protein translocation protein SEC63

1

4

High-throughput

0.579

High

381043

H2B1
Histone H2B.1

1

20

Small-scale

0.561

High

623814

MYO2
Myosin-2

1

10

High-throughput

0.536

High

735981

SP110
Spindle pole body component 110

1

20

High-throughput

0.536

High

743167

PP12
Serine/threonine-protein phosphatase PP1-2

1

13

High-throughput

0.536

High

748871

KEL2
Kelch repeat-containing protein 2

1

12

High-throughput

0.536

High

748872

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

13

High-throughput

0.536

High

748844

MET30
F-box protein MET30

1

14

Small-scale

0.515

High

748814

SPC29
Spindle pole component 29

1

0

High-throughput

0.513

High

748852

PEP8
Carboxypeptidase Y-deficient protein 8

1

0

High-throughput

0.513

High

748923

AHC1
Protein AHC1

1

0

High-throughput

0.513

High

368334

TRPG
Multifunctional tryptophan biosynthesis protein [Includes: Anthranilate synthase component 2

1

8

High-throughput

0.501

High

531672

RL4A
Large ribosomal subunit protein uL4A

1

2

High-throughput

0.501

High

548190

BIK1
Nuclear fusion protein BIK1

1

13

High-throughput

0.501

High

598837

PFKA1
ATP-dependent 6-phosphofructokinase subunit alpha

1

8

High-throughput

0.501

High

598985

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

8

High-throughput

0.501

High

600672

SEC2
Rab guanine nucleotide exchange factor SEC2

1

1

High-throughput

0.501

High

617855

DDR48
Stress protein DDR48

1

1

High-throughput

0.501

High

663311

FPS1
Glycerol uptake/efflux facilitator protein

1

3

High-throughput

0.501

High

668424

PTP1
Tyrosine-protein phosphatase 1

1

9

High-throughput

0.501

High

701590

UBC8
Ubiquitin-conjugating enzyme E2-24 kDa

1

10

High-throughput

0.501

High

740290

PAH1
Phosphatidic acid phosphohydrolase 1

1

4

High-throughput

0.501

High

745118

YME1
Mitochondrial inner membrane i-AAA protease supercomplex subunit YME1

1

12

High-throughput

0.501

High

746601

DRS1
ATP-dependent RNA helicase DRS1

1

14

High-throughput

0.501

High

746718

KPR1
Ribose-phosphate pyrophosphokinase 1

1

10

High-throughput

0.501

High

748819

SKT5
Chitin synthase regulator SKT5

1

3

High-throughput

0.501

High

748822

ELF1
Transcription elongation factor 1

1

1

High-throughput

0.501

High

748830

LEO1
RNA polymerase-associated protein LEO1

1

1

High-throughput

0.501

High

748835

YNG2
Chromatin modification-related protein YNG2

1

1

High-throughput

0.501

High

748841

RGD3
Rho-GTPase-activating protein RGD3

1

2

High-throughput

0.501

High

748847

YAT2
Carnitine O-acetyltransferase YAT2

1

3

High-throughput

0.501

High

748853

6P21
6-phosphofructo-2-kinase 1

1

8

High-throughput

0.501

High

748861

IRC5
Uncharacterized ATP-dependent helicase IRC5

1

3

High-throughput

0.501

High

748865

ARC1
tRNA-aminoacylation cofactor ARC1

1

1

High-throughput

0.501

High

748866

ALY2
Arrestin-related trafficking adapter 3

1

4

High-throughput

0.501

High

748873

SKP1
Suppressor of kinetochore protein 1

1

2

High-throughput

0.501

High

748881

GYP2
GTPase-activating protein GYP2

1

4

High-throughput

0.501

High

748886

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

14

High-throughput

0.501

High

748890

SUB1
RNA polymerase II transcriptional coactivator SUB1

1

2

High-throughput

0.501

High

748894

ERB1
Ribosome biogenesis protein ERB1

1

7

High-throughput

0.501

High

748898

CD123
Translation initiation factor eIF2 assembly protein

1

2

High-throughput

0.501

High

748899

KYNU
Kynureninase

1

1

High-throughput

0.501

High

748902

URN1
Pre-mRNA-splicing factor URN1

1

1

High-throughput

0.501

High

748909

BDF2
Bromodomain-containing factor 2

1

16

High-throughput

0.501

High

748913

AB140
tRNA(Thr)

1

1

High-throughput

0.501

High

748914

CTI6
Histone deacetylase complex subunit CTI6

1

1

High-throughput

0.501

High

748920

HAT1
Histone acetyltransferase type B catalytic subunit

1

0

High-throughput

0.493

High

748833

VPS29
Vacuolar protein sorting-associated protein 29

1

1

High-throughput

0.489

High

748883

COPA
Coatomer subunit alpha

1

7

High-throughput

0.489

High

748845

MBO1
Gamma tubulin complex adapter SPC72

1

1

High-throughput

0.481

High

748857

SPR3
Sporulation-regulated protein 3

1

1

High-throughput

0.481

High

748903

NDE1
Nuclear distribution protein nudE homolog 1

1

1

High-throughput

0.481

High

748916

NOP53
Ribosome biogenesis protein NOP53

1

3

High-throughput

0.481

High

470187

MET2
Homoserine O-acetyltransferase

1

0

High-throughput

0.480

High

748824

DRE2
Fe-S cluster assembly protein DRE2

1

0

High-throughput

0.480

High

748825

RNZ
Ribonuclease Z

1

0

High-throughput

0.480

High

748829

SWC5
SWR1-complex protein 5

1

0

High-throughput

0.480

High

748837

NSG1
Protein NSG1

1

0

High-throughput

0.480

High

748838

CHS7
Chitin synthase export chaperone

1

0

High-throughput

0.480

High

748839

LIN1
Protein LIN1

1

0

High-throughput

0.480

High

748842

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.480

High

748848

YEQ9
Uncharacterized protein YER079W

1

0

High-throughput

0.480

High

748849

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

High-throughput

0.480

High

748850

VID27
Vacuolar import and degradation protein 27

1

0

High-throughput

0.480

High

748851

RT106
Histone chaperone RTT106

1

0

High-throughput

0.480

High

748854

UTP25
U3 small nucleolar RNA-associated protein 25

1

0

High-throughput

0.480

High

748859

ECO1
N-acetyltransferase ECO1

1

0

Small-scale

0.480

High

748864

RPA43
DNA-directed RNA polymerase I subunit RPA43

1

0

High-throughput

0.480

High

748867

EAF6
Chromatin modification-related protein EAF6

1

0

High-throughput

0.480

High

748878

SDS23
Protein SDS23

1

0

High-throughput

0.480

High

748879

YG1B
Uncharacterized protein YGR017W

1

0

High-throughput

0.480

High

748884

TR112
Multifunctional methyltransferase subunit TRM112

1

0

High-throughput

0.480

High

748893

TAF12
SAGA complex/transcription factor TFIID complex subunit TAF12

1

0

High-throughput

0.480

High

748897

SVF1
Ceramide-binding protein SVF1

1

0

High-throughput

0.480

High

748901

LOA1
Lysophosphatidic acid:oleoyl-CoA acyltransferase 1

1

0

High-throughput

0.480

High

748906

UBX5
UBX domain-containing protein 5

1

0

High-throughput

0.480

High

748910

IWR1
RNA polymerase II nuclear localization protein IWR1

1

0

High-throughput

0.480

High

748919

USB1
U6 snRNA phosphodiesterase 1

1

0

High-throughput

0.480

High

748921

HIF1
HAT1-interacting factor 1

1

0

High-throughput

0.480

High

748813

TYE7
Transcription factor TYE7

1

0

High-throughput

0.460

High

748904

HDA2
HDA1 complex subunit 2

1

0

High-throughput

0.460

High

562951

CAPZB
F-actin-capping protein subunit beta

1

6

High-throughput

0.457

High

609212

CLC1
Clathrin light chain

1

1

High-throughput

0.457

High

734327

DGR2
2-deoxy-glucose resistant protein 2

1

11

High-throughput

0.457

High

739579

SPT16
FACT complex subunit SPT16

1

6

High-throughput

0.457

High

740709

SRP40
Suppressor protein SRP40

1

1

High-throughput

0.457

High

744704

GPT1
Glycerol-3-phosphate O-acyltransferase 1

1

1

High-throughput

0.457

High

748818

PTH2
Peptidyl-tRNA hydrolase 2

1

1

High-throughput

0.457

High

748831

GLO3
ADP-ribosylation factor GTPase-activating protein GLO3

1

17

High-throughput

0.457

High

748843

SSN2
Mediator of RNA polymerase II transcription subunit 13

1

1

High-throughput

0.457

High

748856

AIM21
Altered inheritance of mitochondria protein 21

1

4

High-throughput

0.457

High

748858

ATG18
Autophagy-related protein 18

1

8

High-throughput

0.457

High

748863

MTHR1
Methylenetetrahydrofolate reductase 1

1

1

High-throughput

0.457

High

748874

SEH1
Nucleoporin SEH1

1

8

High-throughput

0.457

High

748880

ORM1
Protein ORM1

1

5

High-throughput

0.457

High

748887

ESBP6
Uncharacterized transporter ESBP6

1

5

High-throughput

0.457

High

748892

YMD7
Uncharacterized protein YML037C

1

1

High-throughput

0.457

High

748896

IVY1
Protein IVY1

1

1

High-throughput

0.457

High

748900

ORM2
Protein ORM2

1

5

High-throughput

0.457

High

748907

IMH1
Golgin IMH1

1

20

High-throughput

0.457

High

748911

TPO1
Polyamine transporter 1

1

1

High-throughput

0.457

High

748918

SSF2
Ribosome biogenesis protein SSF2

1

1

High-throughput

0.457

High

555049

G6PI
Glucose-6-phosphate isomerase

1

2

High-throughput

0.457

High

748834

SSZ1
Ribosome-associated complex subunit SSZ1

1

18

High-throughput

0.445

High

748820

CASP
Protein CASP

1

20

High-throughput

0.439

High

748888

APP1
Phosphatidate phosphatase APP1

2

0

High-throughput

0.307

High

739106

PT309
Mitochondrial COX1 translation regulator PET309

1

0

High-throughput

0.279

Low

748815

VPS35
Vacuolar protein sorting-associated protein 35

1

0

High-throughput

0.279

Low

464505

CHS1
Chitin synthase 1

1

0

High-throughput

0.261

Low

748816

MFA2
Mating hormone A-factor 2

1

0

High-throughput

0.261

Low

748821

SFK1
Protein SFK1

1

0

High-throughput

0.261

Low

748827

MRX3
MIOREX complex component 3

1

0

High-throughput

0.261

Low

748846

HPH2
Protein HPH2

1

0

High-throughput

0.261

Low

748855

PUP1
PUP1 protein homolog

1

0

High-throughput

0.261

Low

748860

PTR3
SPS-sensor component PTR3

1

0

High-throughput

0.261

Low

748869

YG3O
Uncharacterized protein YGR153W

1

0

High-throughput

0.261

Low

748877

KXD1
Biogenesis of lysosome-related organelles complex 1 subunit KXD1

1

0

High-throughput

0.261

Low

748882

SUN4
Probable secreted beta-glucosidase SUN4

1

0

High-throughput

0.261

Low

748905

OMS1
Methyltransferase OMS1, mitochondrial

1

0

High-throughput

0.261

Low

748912

UTP16
U3 small nucleolar RNA-associated protein 16

1

0

High-throughput

0.261

Low

748917

YL125
Putative uncharacterized protein YLR125W

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025