Protein: DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10 (EC 2.3.2.27) (RING-type E3 ubiquitin transferase DOA10)

Gene: DOA10, SSM4
Organism: Saccharomyces cerevisiae S288C
Interactions: 108
UniProt ID: P40318

Gene Ontology (top 5):
GO:0000837 - Doa10p ubiquitin ligase complex
GO:0004842 - ubiquitin-protein transferase activity
GO:0005635 - nuclear envelope
GO:0005637 - nuclear inner membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

822275

UBC7
Ubiquitin-conjugating enzyme E2 7

9

20

Small-scale

0.754

High

750592

UBC6
Ubiquitin-conjugating enzyme E2 6

8

20

Small-scale

0.747

High

679750

CDC48
Cell division control protein 48

6

5

Small-scale

0.729

High

822280

UBX2
UBX domain-containing protein 2

5

0

Small-scale

0.690

High

799705

CUE1
Coupling of ubiquitin conjugation to ER degradation protein 1

5

0

Small-scale

0.682

High

509583

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

2

9

Small-scale

0.602

High

822246

DOA10
ERAD-associated E3 ubiquitin-protein ligase DOA10

2

12

Small-scale

0.602

High

556573

STE6
Alpha-factor-transporting ATPase

2

2

Small-scale

0.567

High

822278

NHX1
Endosomal/prevacuolar sodium/hydrogen exchanger

1

1

High-throughput

0.541

High

822264

UFD1
Ubiquitin fusion degradation protein 1

1

0

Small-scale

0.530

High

822249

SYA
Alanine--tRNA ligase, mitochondrial

1

1

High-throughput

0.501

High

822259

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

5

High-throughput

0.501

High

822281

HFD1
Fatty aldehyde dehydrogenase HFD1

1

4

High-throughput

0.501

High

822290

LKHA4
Leucine aminopeptidase 2

1

1

High-throughput

0.501

High

822269

PDR18
ABC transporter ATP-binding protein/permease PDR18

1

2

High-throughput

0.494

High

822261

SC6B1
Protein transport protein SBH1

1

1

Small-scale

0.481

High

358408

ADH2
Alcohol dehydrogenase 2

1

0

High-throughput

0.480

High

470649

ERG20
Farnesyl pyrophosphate synthase

1

0

High-throughput

0.480

High

610156

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.480

High

677130

POF1
Nicotinamide mononucleotide adenylyltransferase

1

0

High-throughput

0.480

High

822282

SEC13
Protein transport protein SEC13

1

0

High-throughput

0.480

High

822283

GSF2
Glucose-signaling factor 2

1

0

High-throughput

0.480

High

822287

NOB1
20S-pre-rRNA D-site endonuclease NOB1

1

0

High-throughput

0.480

High

822262

SC6B2
Protein transport protein SBH2

1

1

Small-scale

0.479

High

822291

DFM1
DER1-like family member protein 1

1

1

Small-scale

0.479

High

798738

ATU1
P-type cation-transporting ATPase

1

1

Small-scale

0.470

High

822263

SCS3
Acyl-coenzyme A diphosphatase SCS3

1

0

Small-scale

0.460

High

649225

SAN1
Protein SAN1

1

0

Small-scale

0.458

High

707256

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.458

High

734804

VPH2
Vacuolar ATPase assembly integral membrane protein VPH2

1

0

Small-scale

0.458

High

748419

SC61A
Protein transport protein SEC61

1

0

Small-scale

0.458

High

754434

NPL4
Nuclear protein localization protein 4

1

0

Small-scale

0.458

High

780761

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

822276

PEX29
Peroxisomal membrane protein PEX29

1

0

Small-scale

0.458

High

822286

PEX15
Peroxisomal membrane protein PEX15

1

0

Small-scale

0.458

High

367979

ENO2
Enolase 2

1

2

High-throughput

0.457

High

526837

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.457

High

668431

PTP1
Tyrosine-protein phosphatase 1

1

9

High-throughput

0.457

High

676874

YCC1
Putative uncharacterized protein YCL021W

1

1

High-throughput

0.457

High

745762

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

2

High-throughput

0.457

High

751967

LHP1
La protein homolog

1

1

High-throughput

0.457

High

794389

MAL32
Alpha-glucosidase MAL32

1

4

High-throughput

0.457

High

802838

YHR2
Uncharacterized trans-sulfuration enzyme YHR112C

1

1

High-throughput

0.457

High

822251

MVP1
Sorting nexin MVP1

1

1

High-throughput

0.457

High

822256

SYEC
Glutamate--tRNA ligase, cytoplasmic

1

1

High-throughput

0.457

High

822260

SOL1
6-phosphogluconolactonase-like protein 1

1

1

High-throughput

0.457

High

822265

MALX3
Oligo-1,6-glucosidase IMA1

1

4

High-throughput

0.457

High

822266

STR3
Cystathionine beta-lyase

1

1

High-throughput

0.457

High

822267

YGD9
Putative uncharacterized oxidoreductase YGL039W

1

2

High-throughput

0.457

High

822271

YL460
Uncharacterized protein YLR460C

1

2

High-throughput

0.457

High

822272

PROA
Gamma-glutamyl phosphate reductase

1

4

High-throughput

0.457

High

822274

CTF4
DNA polymerase alpha-binding protein

1

1

High-throughput

0.457

High

822292

YPT6
GTP-binding protein YPT6

1

3

High-throughput

0.457

High

579496

HSC82
ATP-dependent molecular chaperone HSC82

1

5

High-throughput

0.437

High

750954

PRS7
26S proteasome regulatory subunit 7 homolog

1

3

Small-scale

0.437

High

808511

TEM1
Protein TEM1

1

2

High-throughput

0.437

High

741686

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

807082

FKBP3
Peptidyl-prolyl cis-trans isomerase

1

1

Small-scale

0.407

High

822248

YIG0
Uncharacterized protein YIL060W

1

0

High-throughput

0.391

High

511063

ERR1
Enolase-related protein 1

1

2

High-throughput

0.373

High

366807

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.261

Low

446233

PHSG
Glycogen phosphorylase

1

0

High-throughput

0.261

Low

521093

YEY2
Uncharacterized protein YER152C

1

0

High-throughput

0.261

Low

534187

PCKA
Phosphoenolpyruvate carboxykinase

1

0

High-throughput

0.261

Low

538341

PYC1
Pyruvate carboxylase 1

1

0

High-throughput

0.261

Low

582246

AMPD
AMP deaminase

1

0

High-throughput

0.261

Low

591954

THRC
Threonine synthase

1

0

High-throughput

0.261

Low

596931

PDC5
Pyruvate decarboxylase isozyme 2

1

0

High-throughput

0.261

Low

599031

PFKA2
ATP-dependent 6-phosphofructokinase subunit beta

1

0

High-throughput

0.261

Low

601062

RL8A
Large ribosomal subunit protein eL8A

1

0

High-throughput

0.261

Low

638725

RIR1
Ribonucleoside-diphosphate reductase large chain 1

1

0

High-throughput

0.261

Low

660228

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.261

Low

677933

YCQ6
Uncharacterized protein YCR016W

1

0

High-throughput

0.261

Low

723612

MLS1
Malate synthase 1

1

0

High-throughput

0.261

Low

727074

HS104
Heat shock protein 104

1

0

High-throughput

0.261

Low

733663

GLNA
Glutamine synthetase

1

0

High-throughput

0.261

Low

763765

THI80
Thiamine pyrophosphokinase

1

0

High-throughput

0.261

Low

789787

ADCS
Aminodeoxychorismate synthase

1

0

High-throughput

0.261

Low

791964

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

1

0

High-throughput

0.261

Low

793220

YBQ6
Uncharacterized glycosyl hydrolase YBR056W

1

0

High-throughput

0.261

Low

802945

6PGD1
6-phosphogluconate dehydrogenase, decarboxylating 1

1

0

High-throughput

0.261

Low

803489

TDA3
Putative oxidoreductase TDA3

1

0

High-throughput

0.261

Low

804138

PANE
2-dehydropantoate 2-reductase

1

0

High-throughput

0.261

Low

808788

LYS1
Saccharopine dehydrogenase [NAD(+), L-lysine-forming]

1

0

High-throughput

0.261

Low

809326

STM1
Suppressor protein STM1

1

0

High-throughput

0.261

Low

813385

NPT1
Nicotinate phosphoribosyltransferase

1

0

High-throughput

0.261

Low

821011

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

High-throughput

0.261

Low

822247

MAM33
Mitochondrial acidic protein MAM33

1

0

High-throughput

0.261

Low

822250

YJV8
Putative acetyltransferase YJL218W

1

0

High-throughput

0.261

Low

822253

OYE3
NADPH dehydrogenase 3

1

0

High-throughput

0.261

Low

822254

PTE1
Peroxisomal acyl-coenzyme A thioester hydrolase 1

1

0

High-throughput

0.261

Low

822255

MTHR1
Methylenetetrahydrofolate reductase 1

1

0

High-throughput

0.261

Low

822257

AIP1
Actin-interacting protein 1

1

0

High-throughput

0.261

Low

822258

YJ66
Uncharacterized oxidoreductase YJR096W

1

0

High-throughput

0.261

Low

822268

YG2W
Uncharacterized protein YGR111W

1

0

High-throughput

0.261

Low

822270

IDHH
Isocitrate dehydrogenase [NADP]

1

0

High-throughput

0.261

Low

822273

PURA
Adenylosuccinate synthetase

1

0

High-throughput

0.261

Low

822279

ARA2
D-arabinose 1-dehydrogenase

1

0

High-throughput

0.261

Low

822284

KYNU
Kynureninase

1

0

High-throughput

0.261

Low

822285

DLHH
Putative carboxymethylenebutenolidase

1

0

High-throughput

0.261

Low

822288

THTR
Thiosulfate sulfurtransferase TUM1

1

0

High-throughput

0.261

Low

822289

SELO
Protein adenylyltransferase SelO, mitochondrial

1

0

High-throughput

0.261

Low

558749

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.249

Low

645933

DBF2
Cell cycle protein kinase DBF2

1

0

High-throughput

0.249

Low

736530

MFAL2
Mating factor alpha-2

1

0

Small-scale

0.249

Low

822252

PRP17
Pre-mRNA-processing factor 17

1

0

Small-scale

0.249

Low

822277

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025