Protein: SENP8
Sentrin-specific protease 8 (EC 3.4.22.-) (Deneddylase-1) (NEDD8-specific protease 1) (Protease, cysteine 2) (Sentrin/SUMO-specific protease SENP8)

Gene: SENP8
Organism: Homo sapiens
Interactions: 22
UniProt ID: Q96LD8

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0008234 - cysteine-type peptidase activity
GO:0016579 - protein deubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1154906

NEDD8
Ubiquitin-like protein NEDD8

6

6

Small-scale

0.948

High

1112660

CUL1
Cullin-1

2

8

Small-scale

0.629

High

914020

CHIO
Beta-chimaerin

2

1

High-throughput

0.606

High

958696

CSN2
COP9 signalosome complex subunit 2

1

1

Small-scale

0.561

High

857158

NSF
Vesicle-fusing ATPase

1

2

High-throughput

0.515

High

1115004

CUL4A
Cullin-4A

1

9

Small-scale

0.512

High

761824

HSP74
Heat shock 70 kDa protein 4

1

5

Small-scale

0.501

High

1094399

CSN1
COP9 signalosome complex subunit 1

1

1

Small-scale

0.501

High

1112958

CUL2
Cullin-2

1

8

Small-scale

0.501

High

1397026

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

1

6

High-throughput

0.501

High

1397027

SMUF1
E3 ubiquitin-protein ligase SMURF1

1

3

Small-scale

0.501

High

1397029

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

3

High-throughput

0.501

High

1397031

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

3

High-throughput

0.501

High

1397030

HDGR3
Hepatoma-derived growth factor-related protein 3

1

0

High-throughput

0.493

High

957478

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

Small-scale

0.480

High

972522

RS14
Small ribosomal subunit protein uS11

1

1

Small-scale

0.479

High

572752

PA2GA
Phospholipase A2, membrane associated

1

1

Small-scale

0.457

High

985819

RL11
Large ribosomal subunit protein uL5

1

1

Small-scale

0.445

High

1390911

IFT43
Intraflagellar transport protein 43 homolog

2

0

High-throughput

0.328

High

1397028

AKIP1
A-kinase-interacting protein 1

1

0

Small-scale

0.292

High

928522

TERF1
Telomeric repeat-binding factor 1

1

0

Small-scale

0.261

Low

551204

PCNA
Proliferating cell nuclear antigen

1

0

Small-scale

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025