Protein: UBP28
Ubiquitin carboxyl-terminal hydrolase 28 (EC 3.4.19.12) (Deubiquitinating enzyme 28) (Ubiquitin thioesterase 28) (Ubiquitin-specific-processing protease 28)

Gene: UBP28, USP28
Organism: Homo sapiens
Interactions: 114
UniProt ID: Q96RU2

Gene Ontology (top 5):
GO:0000077 - DNA damage checkpoint signaling
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508480

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

9

20

Small-scale

0.977

High

1402005

UBP28
Ubiquitin carboxyl-terminal hydrolase 28

3

14

Small-scale

0.884

High

1402022

UBP25
Ubiquitin carboxyl-terminal hydrolase 25

3

17

High-throughput

0.871

High

372908

MYC
Myc proto-oncogene protein

6

20

Small-scale

0.729

High

1088983

TP53B
TP53-binding protein 1

5

11

Small-scale

0.709

High

329097

KLHL2
Kelch-like protein 2

3

12

Small-scale

0.656

High

828243

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

16

High-throughput

0.647

High

853515

UBP5
Ubiquitin carboxyl-terminal hydrolase 5

1

14

High-throughput

0.647

High

930023

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

17

High-throughput

0.647

High

1094615

UBP4
Ubiquitin carboxyl-terminal hydrolase 4

1

20

High-throughput

0.647

High

1258105

UBP51
Ubiquitin carboxyl-terminal hydrolase 51

1

15

High-throughput

0.647

High

1353411

UBP33
Ubiquitin carboxyl-terminal hydrolase 33

1

19

High-throughput

0.647

High

1371621

UBP7
Ubiquitin carboxyl-terminal hydrolase 7

1

16

High-throughput

0.647

High

1402023

UBP21
Ubiquitin carboxyl-terminal hydrolase 21

1

19

High-throughput

0.647

High

1402025

UBP20
Ubiquitin carboxyl-terminal hydrolase 20

1

20

High-throughput

0.647

High

1402027

UBP15
Ubiquitin carboxyl-terminal hydrolase 15

1

20

High-throughput

0.647

High

414454

P53
Cellular tumor antigen p53

3

8

Small-scale

0.641

High

246884

KDM1A
Lysine-specific histone demethylase 1A

2

9

Small-scale

0.634

High

964426

SUMO2
Small ubiquitin-related modifier 2

2

8

Small-scale

0.634

High

1402014

SENP2
Sentrin-specific protease 2

2

6

High-throughput

0.628

High

242662

PRKN
E3 ubiquitin-protein ligase parkin

1

20

High-throughput

0.618

High

1380103

FBXW7
F-box/WD repeat-containing protein 7

1

11

Small-scale

0.618

High

1350043

SPP2B
Signal peptide peptidase-like 2B

2

0

High-throughput

0.602

High

827900

STAT3
Signal transducer and activator of transcription 3

2

7

Small-scale

0.584

High

1143085

KPCD1
Serine/threonine-protein kinase D1

1

7

Small-scale

0.561

High

1402019

SENP1
Sentrin-specific protease 1

1

6

Small-scale

0.561

High

564252

CFTR
Cystic fibrosis transmembrane conductance regulator

1

3

High-throughput

0.541

High

923628

TTC3
E3 ubiquitin-protein ligase TTC3

1

8

High-throughput

0.541

High

1402012

UCK1
Uridine-cytidine kinase 1

1

0

Small-scale

0.537

High

65888

MSGN1
Mesogenin-1

1

4

High-throughput

0.536

High

245142

AQR
RNA helicase aquarius

1

3

High-throughput

0.536

High

290119

OFD1
Centriole and centriolar satellite protein OFD1

1

2

High-throughput

0.536

High

578535

BRAF
Serine/threonine-protein kinase B-raf

1

8

High-throughput

0.536

High

611953

RL35A
Large ribosomal subunit protein eL33

1

1

High-throughput

0.536

High

783380

TRI23
E3 ubiquitin-protein ligase TRIM23

1

5

High-throughput

0.536

High

799416

BRCA1
Breast cancer type 1 susceptibility protein

1

20

High-throughput

0.536

High

991681

DYL1
Dynein light chain 1, cytoplasmic

1

3

High-throughput

0.536

High

1017471

FOXK1
Forkhead box protein K1

1

11

High-throughput

0.536

High

1034969

GCYB1
Guanylate cyclase soluble subunit beta-1

1

3

High-throughput

0.536

High

1143488

PCM1
Pericentriolar material 1 protein

1

1

High-throughput

0.536

High

1365964

APBP2
Amyloid protein-binding protein 2

1

4

High-throughput

0.536

High

1390700

DYL2
Dynein light chain 2, cytoplasmic

1

3

High-throughput

0.536

High

1240681

CDC73
Parafibromin

1

2

Small-scale

0.527

High

280950

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.513

High

322453

HAUS5
HAUS augmin-like complex subunit 5

1

0

High-throughput

0.513

High

1402008

CEP44
Centrosomal protein of 44 kDa

1

0

High-throughput

0.513

High

488537

UCHL1
Ubiquitin carboxyl-terminal hydrolase isozyme L1

1

12

High-throughput

0.501

High

583886

UCHL3
Ubiquitin carboxyl-terminal hydrolase isozyme L3

1

12

High-throughput

0.501

High

1098833

M3K1
Mitogen-activated protein kinase kinase kinase 1

1

7

Small-scale

0.501

High

1139182

JOS1
Josephin-1

1

3

High-throughput

0.501

High

1161368

HIF1A
Hypoxia-inducible factor 1-alpha

1

10

Small-scale

0.501

High

1361999

RFFL
E3 ubiquitin-protein ligase rififylin

1

14

High-throughput

0.501

High

1364531

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

12

High-throughput

0.501

High

1368290

STAM1
Signal transducing adapter molecule 1

1

4

High-throughput

0.501

High

1380829

TRI63
E3 ubiquitin-protein ligase TRIM63

1

20

High-throughput

0.501

High

1387326

OTUB2
Ubiquitin thioesterase OTUB2

1

4

High-throughput

0.501

High

1391012

OTUB1
Ubiquitin thioesterase OTUB1

1

4

High-throughput

0.501

High

1397026

SENP8
Sentrin-specific protease 8

1

6

High-throughput

0.501

High

1402007

TRI55
Tripartite motif-containing protein 55

1

20

High-throughput

0.501

High

1402010

ATX3L
Ataxin-3-like protein

1

3

High-throughput

0.501

High

1402028

UCHL5
Ubiquitin carboxyl-terminal hydrolase isozyme L5

1

12

High-throughput

0.501

High

657293

KALM
Anosmin-1

1

6

High-throughput

0.489

High

1101637

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.489

High

340665

STABP
STAM-binding protein

1

0

High-throughput

0.480

High

1129566

ESPL1
Separin

1

0

High-throughput

0.480

High

1398146

NSE2
E3 SUMO-protein ligase NSE2

1

0

Small-scale

0.480

High

170300

AURKA
Aurora kinase A

1

14

Small-scale

0.479

High

260335

BRD4
Bromodomain-containing protein 4

1

18

High-throughput

0.479

High

520308

ANDR
Androgen receptor

1

18

High-throughput

0.479

High

541052

PIM1
Serine/threonine-protein kinase pim-1

1

12

Small-scale

0.479

High

551212

PCNA
Proliferating cell nuclear antigen

1

3

High-throughput

0.479

High

591353

CD44
CD44 antigen

1

3

Small-scale

0.479

High

857541

NOTC1
Neurogenic locus notch homolog protein 1

1

12

Small-scale

0.479

High

920213

PLK1
Serine/threonine-protein kinase PLK1

1

20

High-throughput

0.479

High

986654

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

5

High-throughput

0.479

High

1085463

SRBP2
Sterol regulatory element-binding protein 2

1

11

Small-scale

0.479

High

1102229

ATM
Serine-protein kinase ATM

1

8

Small-scale

0.479

High

1129707

MDC1
Mediator of DNA damage checkpoint protein 1

1

20

Small-scale

0.479

High

1134687

NUMA1
Nuclear mitotic apparatus protein 1

1

20

Small-scale

0.479

High

1276675

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

10

High-throughput

0.479

High

1289559

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1334802

SERB1
SERPINE1 mRNA-binding protein 1

1

5

High-throughput

0.479

High

1337309

PK3C3
Phosphatidylinositol 3-kinase catalytic subunit type 3

1

1

Small-scale

0.479

High

1351951

RBCC1
RB1-inducible coiled-coil protein 1

1

20

High-throughput

0.479

High

1371352

TF3B
Transcription factor IIIB 90 kDa subunit

1

4

Small-scale

0.479

High

1380931

OSBP2
Oxysterol-binding protein 2

1

1

High-throughput

0.479

High

1399830

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

Small-scale

0.479

High

1402009

P63
Tumor protein 63

1

8

Small-scale

0.479

High

1402011

LN28A
Protein lin-28 homolog A

1

7

Small-scale

0.479

High

1402013

CLSPN
Claspin

1

5

Small-scale

0.479

High

1402015

ZN304
Zinc finger protein 304

1

6

Small-scale

0.479

High

1402016

TF7L2
Transcription factor 7-like 2

1

12

Small-scale

0.479

High

1402017

METL5
rRNA N(6)-adenosine-methyltransferase METTL5

1

3

Small-scale

0.479

High

1402018

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

1

High-throughput

0.479

High

1402021

ZRAN1
Ubiquitin thioesterase ZRANB1

1

10

High-throughput

0.479

High

1402024

NUP50
Nuclear pore complex protein Nup50

1

3

High-throughput

0.479

High

869785

MTR1A
Melatonin receptor type 1A

1

6

High-throughput

0.464

High

572753

PA2GA
Phospholipase A2, membrane associated

1

5

Small-scale

0.457

High

1339836

PJA1
E3 ubiquitin-protein ligase Praja-1

1

13

High-throughput

0.457

High

896440

ERF
ETS domain-containing transcription factor ERF

1

10

High-throughput

0.445

High

967932

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

5

High-throughput

0.445

High

1239278

ARMC6
Armadillo repeat-containing protein 6

1

2

High-throughput

0.445

High

1278081

MAVS
Mitochondrial antiviral-signaling protein

1

19

Small-scale

0.437

High

1402020

PIM2
Serine/threonine-protein kinase pim-2

1

6

Small-scale

0.437

High

94325

D6R9G5
Kelch like family member 2

1

12

High-throughput

0.407

High

437767

HEPS
Serine protease hepsin

1

6

High-throughput

0.407

High

1366190

LPAR1
Lysophosphatidic acid receptor 1

1

7

High-throughput

0.407

High

1291664

CMTD1
Catechol O-methyltransferase domain-containing protein 1

4

0

High-throughput

0.360

High

1402026

RT07
Small ribosomal subunit protein uS7m

3

0

High-throughput

0.345

High

587362

SIAT1
Beta-galactoside alpha-2,6-sialyltransferase 1

2

0

High-throughput

0.328

High

1286645

TEDC1
Tubulin epsilon and delta complex protein 1

1

0

High-throughput

0.279

Low

1397826

CC138
Coiled-coil domain-containing protein 138

1

0

High-throughput

0.279

Low

1402006

PAFA2
Platelet-activating factor acetylhydrolase 2, cytoplasmic

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025