HitPredict

Interactor 1: SRPK2 (P78362)
SRSF protein kinase 2 (EC 2.7.11.1) (SFRS protein kinase 2) (Serine/arginine-rich protein-specific kinase 2) (SR-protein-specific kinase 2) [Cleaved into: SRSF protein kinase 2 N-terminal; SRSF protein kinase 2 C-terminal]
Gene: SRPK2

Interactor 2: SFR19 (Q9H7N4)
Splicing factor, arginine/serine-rich 19 (SR-related C-terminal domain-associated factor 1) (SR-related and CTD-associated factor 1) (SR-related-CTD-associated factor) (SCAF) (Serine arginine-rich pre-mRNA splicing factor SR-A1) (SR-A1)
Gene: SCAF1

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.80	0.60	0.694

Property	Details
Experiments	26167880, 33961781, 32707033, unassigned3799
Identification Methods	enzymatic study, affinity chromatography technology, pull down, anti tag coimmunoprecipitation
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0003723 - RNA binding GO:0005634 - nucleus GO:0008380 - RNA splicing
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 688 Hs			1 1312
+	Hs
		1006767 SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00		PHRF1_HUMAN (68-1292): 4.5e-47: 187: 15.98
+	Hs
		1006652 SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00		SCAFB_HUMAN (53-1289): 2.3e-45: 181: 13.23
+	Hs
		1006403 SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00		MDC1_HUMAN (2-1063): 1.02e-34: 147: 8.90
+	Hs
		1006645 SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00		MINT_HUMAN (194-1070): 3.67e-12: 73.8: 14.95
+	Hs
		1006380 SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00		PRP4K_HUMAN (514-804): 6.21e-11: 69.2: 20.82
+	Hs
		1006800 SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00		SRRM2_HUMAN (504-1295): 3.61e-10: 67.2: 8.59
+	Hs
		1006471 SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00		MAP1S_HUMAN (157-602): 6.8e-10: 66.1: 16.22
+	Hs
		1006598 SRPK2_HUMAN (12-688): 4.41e-127: 393: 100.00		TITIN_HUMAN (75-961): 9.26e-10: 65.8: 11.49
+	Hs
		1109200 SRPK1_HUMAN (27-688): 2.64e-125: 388: 53.00		PRP4K_HUMAN (514-804): 6.21e-11: 69.2: 20.82
+	Hs
		1402642 SRPK1_HUMAN (27-688): 2.64e-125: 388: 53.00		SRRM2_HUMAN (504-1295): 3.61e-10: 67.2: 8.59
+	Hs
		1129782 KS6A6_HUMAN (2-347): 2.33e-75: 259: 15.75		MDC1_HUMAN (2-1063): 1.02e-34: 147: 8.90
+	Hs
		1405511 SRPK3_HUMAN (453-687): 8.64e-64: 223: 67.23		SCAFB_HUMAN (53-1289): 2.3e-45: 181: 13.23
+	Hs
		668075 CDK2_HUMAN (378-687): 2.51e-89: 282: 16.83		SRRM2_HUMAN (504-1295): 3.61e-10: 67.2: 8.59
+	Hs
		667952 CDK2_HUMAN (378-687): 2.51e-89: 282: 16.83		TITIN_HUMAN (75-961): 9.26e-10: 65.8: 11.49
+	Sp
		206132 DSK1_SCHPO (437-686): 7.44e-74: 250: 44.40		YFHH_SCHPO (6-401): 2.24e-10: 67.5: 13.76
+	Hs
		1109242 SRPK3_HUMAN (453-687): 8.64e-64: 223: 67.23		PRP4K_HUMAN (514-804): 6.21e-11: 69.2: 20.82
+	Hs
		1462450 SRPK3_HUMAN (453-687): 8.64e-64: 223: 67.23		SRRM2_HUMAN (504-1295): 3.61e-10: 67.2: 8.59
+	Hs
		889563 CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73		PRP4K_HUMAN (514-804): 6.21e-11: 69.2: 20.82
+	Hs
		889681 CLK2_HUMAN (62-229): 1.41e-63: 221: 33.73		SRRM2_HUMAN (504-1295): 3.61e-10: 67.2: 8.59
+	Hs
		1361881 DYRK2_HUMAN (51-234): 1.49e-62: 221: 29.35		TITIN_HUMAN (75-961): 9.26e-10: 65.8: 11.49