HitPredict

Interactor 1: CRUM1 (P82279)
Protein crumbs homolog 1
Gene: CRB1

Interactor 2: MIB1 (Q86YT6)
E3 ubiquitin-protein ligase MIB1 (EC 2.3.2.27) (DAPK-interacting protein 1) (DIP-1) (Mind bomb homolog 1) (RING-type E3 ubiquitin transferase MIB1) (Zinc finger ZZ type with ankyrin repeat domain protein 2)
Gene: MIB1

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	31462741
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1406 Hs			1 1006
+	Mm
		1281843 JAG2_MOUSE (4-378): 3.21e-33: 142: 22.70		MIB1_MOUSE (1-1006): 0: 872: 99.30
+	Mm
		1281842 JAG1_MOUSE (1030-1398): 3.05e-29: 129: 22.04		MIB1_MOUSE (1-1006): 0: 872: 99.30
+	Hs
		1008018 JAG1_HUMAN (423-1135): 6.07e-29: 128: 12.43		MIB1_HUMAN (1-1006): 0: 869: 100.00
+	Hs
		139657 DLL1_HUMAN (1139-1267): 1.24e-20: 100: 40.77		MIB1_HUMAN (1-1006): 0: 869: 100.00
+	Mm
		1222787 DLL1_MOUSE (317-514): 1.47e-11: 71.2: 29.25		MIB1_MOUSE (1-1006): 0: 872: 99.30
+	Dr
		1281823 DLLC_DANRE (223-506): 1.39e-12: 74.3: 26.92		MIB1_DANRE (1-1006): 0: 829: 91.76
+	Dr
		50960 A1L1P2_DANRE (223-493): 3.4e-11: 70.1: 26.01		MIB1_DANRE (1-1006): 0: 829: 91.76
+	Dr
		1231583 DLLA_DANRE (291-493): 5.46e-11: 69.3: 28.29		MIB1_DANRE (1-1006): 0: 829: 91.76
+	Dm
		451919 NOTCH_DROME (741-1388): 2.11e-57: 221: 18.99		MIB_DROME (8-933): 0: 660: 62.13
+	Dm
		753758 FAT_DROME (885-1255): 8.67e-14: 79.2: 13.58		MIB_DROME (8-933): 0: 660: 62.13
+	Dm
		68582 NOTCH_DROME (741-1388): 2.11e-57: 221: 18.99		A8JNM5_DROME (188-1005): 5.84e-155: 510: 15.14
+	Hs
		1383743 JAG2_HUMAN (509-1280): 1.6e-34: 146: 13.72		MIB2_HUMAN (14-1006): 0: 576: 28.83
+	Dr
		47855 DLLC_DANRE (223-506): 1.39e-12: 74.3: 26.92		A0AR23_DANRE (3-1006): 0: 589: 28.36
+	Dr
		47832 A1L1P2_DANRE (223-493): 3.4e-11: 70.1: 26.01		A0AR23_DANRE (3-1006): 0: 589: 28.36
+	Dr
		47845 DLLA_DANRE (291-493): 5.46e-11: 69.3: 28.29		A0AR23_DANRE (3-1006): 0: 589: 28.36
+	Hs
		177336 NOTC3_HUMAN (2-1008): 2.49e-76: 282: 19.41		ANR28_HUMAN (194-583): 3.87e-61: 228: 17.15
+	Hs
		177204 NOTC2_HUMAN (629-1397): 6.53e-64: 243: 16.65		ANR28_HUMAN (194-583): 3.87e-61: 228: 17.15
+	Hs
		1331020 NOTC3_HUMAN (2-1008): 2.49e-76: 282: 19.41		ANR44_HUMAN (191-343): 1.86e-10: 67.2: 9.09
+	Hs
		1047634 NOTC2_HUMAN (629-1397): 6.53e-64: 243: 16.65		ANR44_HUMAN (191-343): 1.86e-10: 67.2: 9.09
+	Hs
		857505 NOTC1_HUMAN (742-1398): 2.76e-51: 201: 16.96		ANR44_HUMAN (191-343): 1.86e-10: 67.2: 9.09