HitPredict

Interactor 1: PTPRJ (Q12913)
Receptor-type tyrosine-protein phosphatase eta (Protein-tyrosine phosphatase eta) (R-PTP-eta) (EC 3.1.3.48) (Density-enhanced phosphatase 1) (DEP-1) (HPTP eta) (Protein-tyrosine phosphatase receptor type J) (R-PTP-J) (CD antigen CD148)
Gene: PTPRJ

Interactor 2: GAB1 (Q13480)
GRB2-associated-binding protein 1 (GRB2-associated binder 1) (Growth factor receptor bound protein 2-associated protein 1)
Gene: GAB1

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.58	0.60	0.595

Property	Details
Experiments	19167335, 12475979
Identification Methods	phosphatase assay, pull down
Interaction Type	dephosphorylation reaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0001525 - angiogenesis GO:0005911 - cell-cell junction
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 1337 Hs			1 694
+	Hs
		577020 PTPRA_HUMAN (521-1304): 2.08e-110: 368: 19.78		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		617108 PTPRG_HUMAN (757-1329): 3.11e-55: 213: 17.43		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		616917 PTPRB_HUMAN (463-930): 1.38e-23: 111: 16.63		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		1035378 PTPRO_HUMAN (46-453): 1.96e-21: 103: 14.92		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Hs
		441197 PTPRC_HUMAN (47-298): 3.49e-10: 67: 9.89		GAB1_HUMAN (1-694): 0: 547: 100.00
+	Mm
		1194483 TENR_MOUSE (84-624): 4.51e-118: 403: 22.13		CNKR2_MOUSE (7-393): 1.86e-56: 210: 16.38
+	Hs
		1153281 CNTN4_HUMAN (4-536): 3.9e-35: 147: 11.84		PKHA7_HUMAN (5-485): 5.86e-74: 260: 12.07
+	Hs
		793660 DCC_HUMAN (270-1127): 5.82e-71: 264: 10.61		MYO10_HUMAN (2-301): 2.1e-29: 127: 14.89
+	Mm
		101522 NEO1_MOUSE (1-539): 2.35e-45: 181: 13.73		MYO10_MOUSE (2-301): 1.6e-28: 124: 14.59