HitPredict

Interactor 1: TRAF2 (Q12933)
TNF receptor-associated factor 2 (EC 2.3.2.27) (E3 ubiquitin-protein ligase TRAF2) (RING-type E3 ubiquitin transferase TRAF2) (Tumor necrosis factor type 2 receptor-associated protein 3)
Gene: TRAF2

Interactor 2: TAB3 (Q8N5C8)
TGF-beta-activated kinase 1 and MAP3K7-binding protein 3 (Mitogen-activated protein kinase kinase kinase 7-interacting protein 3) (NF-kappa-B-activating protein 1) (TAK1-binding protein 3) (TAB-3) (TGF-beta-activated kinase 1-binding protein 3)
Gene: TAB3

Species: Homo sapiens

Source: innatedb

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.60	0.60	0.601

Property	Details
Experiments	14633987, 19150425
Identification Methods	affinity chromatography technology, anti tag coimmunoprecipitation
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0008270 - zinc ion binding GO:0038061 - non-canonical NF-kappaB signal transduction GO:0043123 - positive regulation of canonical NF-kappaB signal transduction GO:0060090 - molecular adaptor activity
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 501 Hs			1 712
+	Hs
		1234349 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		TAB3_HUMAN (1-712): 8.19e-99: 321: 100.00
+	Mm
		936227 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		TAB3_MOUSE (1-712): 2.53e-96: 315: 94.69
+	Hs
		1020961 TRAF2_HUMAN (1-501): 2.31e-159: 463: 100.00		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53
+	Mm
		761838 TRAF2_MOUSE (1-501): 9.33e-158: 459: 86.83		TAB2_MOUSE (1-711): 4.55e-45: 173: 28.09
+	Hs
		1348535 TRAF6_HUMAN (2-498): 5.24e-109: 335: 27.08		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53
+	Mm
		1111925 TRAF3_MOUSE (9-501): 1.15e-113: 348: 31.75		SMCA4_MOUSE (153-599): 4.6e-41: 164: 11.43
+	Mm
		936273 TRAF6_MOUSE (2-498): 2.51e-110: 339: 27.87		TAB2_MOUSE (1-711): 4.55e-45: 173: 28.09
+	Hs
		135034 TRI38_HUMAN (19-367): 1.53e-53: 189: 14.25		TAB3_HUMAN (1-712): 8.19e-99: 321: 100.00
+	Hs
		1234340 TRIM5_HUMAN (22-324): 8.17e-41: 155: 14.52		TAB3_HUMAN (1-712): 8.19e-99: 321: 100.00
+	Hs
		135043 TRI38_HUMAN (19-367): 1.53e-53: 189: 14.25		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53
+	Hs
		1223392 TRI22_HUMAN (27-331): 6.21e-42: 158: 13.68		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53
+	Hs
		1318714 TRIM5_HUMAN (22-324): 8.17e-41: 155: 14.52		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53
+	Hs
		1052785 TRI25_HUMAN (27-347): 1.26e-39: 153: 12.95		TAB2_HUMAN (1-711): 6.6e-48: 182: 30.53