Protein: EZH1
Histone-lysine N-methyltransferase EZH1 (EC 2.1.1.356) (ENX-2) (Enhancer of zeste homolog 1)

Gene: EZH1
Organism: Homo sapiens
Interactions: 83
UniProt ID: Q92800

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000781 - chromosome, telomeric region
GO:0000792 - heterochromatin
GO:0003682 - chromatin binding
GO:0003714 - transcription corepressor activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

285392

EED
Polycomb protein EED

11

20

Small-scale

0.977

High

1137430

SUZ12
Polycomb protein SUZ12

10

11

Small-scale

0.976

High

1155615

EZH2
Histone-lysine N-methyltransferase EZH2

9

19

Small-scale

0.967

High

1066426

RBBP4
Histone-binding protein RBBP4

4

20

High-throughput

0.900

High

1158949

RBBP7
Histone-binding protein RBBP7

4

20

High-throughput

0.900

High

1213573

PHF19
PHD finger protein 19

5

20

High-throughput

0.720

High

210321

PHF1
PHD finger protein 1

5

20

Small-scale

0.716

High

1368787

JARD2
Protein Jumonji

4

18

Small-scale

0.704

High

1368802

DCA13
DDB1- and CUL4-associated factor 13

1

15

High-throughput

0.691

High

1252559

AEBP2
Zinc finger protein AEBP2

3

18

High-throughput

0.675

High

1368814

MTF2
Metal-response element-binding transcription factor 2

3

20

High-throughput

0.675

High

1368792

LCOR
Ligand-dependent corepressor

3

5

High-throughput

0.662

High

65638

EPOP
Elongin BC and Polycomb repressive complex 2-associated protein

2

20

High-throughput

0.628

High

623467

RO52
E3 ubiquitin-protein ligase TRIM21

1

6

Small-scale

0.618

High

1368786

EZH1
Histone-lysine N-methyltransferase EZH1

1

18

Small-scale

0.618

High

212295

SNUT1
U4/U6.U5 tri-snRNP-associated protein 1

1

1

High-throughput

0.536

High

238930

DHX16
Pre-mRNA-splicing factor ATP-dependent RNA helicase DHX16

1

5

High-throughput

0.536

High

636123

CD11B
Cyclin-dependent kinase 11B

1

4

High-throughput

0.536

High

675608

TYY1
Transcriptional repressor protein YY1

1

12

High-throughput

0.536

High

875739

PRC2A
Protein PRRC2A

1

20

High-throughput

0.536

High

904991

MECP2
Methyl-CpG-binding protein 2

1

15

High-throughput

0.536

High

1088278

SFSWA
Splicing factor, suppressor of white-apricot homolog

1

8

High-throughput

0.536

High

1111154

SNW1
SNW domain-containing protein 1

1

2

High-throughput

0.536

High

1121714

SAFB2
Scaffold attachment factor B2

1

9

High-throughput

0.536

High

1124385

ELOA1
Elongin-A

1

8

High-throughput

0.536

High

1198619

NCBP3
Nuclear cap-binding protein subunit 3

1

1

High-throughput

0.536

High

1207415

HABP4
Intracellular hyaluronan-binding protein 4

1

1

High-throughput

0.536

High

1212012

ZC3HD
Zinc finger CCCH domain-containing protein 13

1

15

High-throughput

0.536

High

1270760

DDX46
Probable ATP-dependent RNA helicase DDX46

1

8

High-throughput

0.536

High

1279879

RBBP6
E3 ubiquitin-protein ligase RBBP6

1

18

High-throughput

0.536

High

1287684

RBM23
Probable RNA-binding protein 23

1

7

High-throughput

0.536

High

1308467

VRK3
Serine/threonine-protein kinase VRK3

1

1

High-throughput

0.536

High

1311553

SUGP1
SURP and G-patch domain-containing protein 1

1

1

High-throughput

0.536

High

1327433

ZGPAT
Zinc finger CCCH-type with G patch domain-containing protein

1

1

High-throughput

0.536

High

1336744

RB15B
Putative RNA-binding protein 15B

1

7

High-throughput

0.536

High

1346872

SNIP1
Smad nuclear-interacting protein 1

1

2

High-throughput

0.536

High

1357076

CATIN
Splicing factor Cactin

1

2

High-throughput

0.536

High

1365834

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

7

High-throughput

0.536

High

1368794

SCAFB
Protein SCAF11

1

6

High-throughput

0.536

High

1368795

BUD13
BUD13 homolog

1

5

High-throughput

0.536

High

1368796

DIDO1
Death-inducer obliterator 1

1

20

High-throughput

0.536

High

1368797

PDIP3
Polymerase delta-interacting protein 3

1

4

High-throughput

0.536

High

1368798

GTPB4
GTP-binding protein 4

1

4

High-throughput

0.536

High

1368799

NSRP1
Nuclear speckle splicing regulatory protein 1

1

1

High-throughput

0.536

High

1368803

ARGL1
Arginine and glutamate-rich protein 1

1

1

High-throughput

0.536

High

1368804

SLTM
SAFB-like transcription modulator

1

20

High-throughput

0.536

High

1368806

M3K20
Mitogen-activated protein kinase kinase kinase 20

1

4

High-throughput

0.536

High

1368807

CDK12
Cyclin-dependent kinase 12

1

6

High-throughput

0.536

High

1368808

RBM27
RNA-binding protein 27

1

10

High-throughput

0.536

High

1368810

INT6
Integrator complex subunit 6

1

1

High-throughput

0.536

High

1368811

TPX2
Targeting protein for Xklp2

1

6

High-throughput

0.536

High

1368812

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

16

High-throughput

0.536

High

1368813

WBP11
WW domain-binding protein 11

1

13

High-throughput

0.536

High

940160

RRP1
Ribosomal RNA processing protein 1 homolog A

1

0

High-throughput

0.513

High

1095154

RED
Protein Red

1

0

High-throughput

0.513

High

1332829

PR38A
Pre-mRNA-splicing factor 38A

1

0

High-throughput

0.513

High

1338158

PPHLN
Periphilin-1

1

0

High-throughput

0.513

High

1346553

RP9
Retinitis pigmentosa 9 protein

1

0

High-throughput

0.513

High

1358169

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

1

0

High-throughput

0.513

High

1368789

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.513

High

1368791

RRP36
Ribosomal RNA processing protein 36 homolog

1

0

High-throughput

0.513

High

1368800

ESF1
ESF1 homolog

1

0

High-throughput

0.513

High

1368805

CWC25
Pre-mRNA-splicing factor CWC25 homolog

1

0

High-throughput

0.513

High

1368809

ZO2
Tight junction protein 2

1

0

High-throughput

0.513

High

64892

RCCD1
RCC1 domain-containing protein 1

1

4

High-throughput

0.489

High

916188

BIEA
Biliverdin reductase A

1

1

High-throughput

0.489

High

1169538

SKDA1
SKI/DACH domain-containing protein 1

1

5

High-throughput

0.489

High

1217827

PR38B
Pre-mRNA-splicing factor 38B

1

3

High-throughput

0.489

High

1368790

RMXL1
RNA binding motif protein, X-linked-like-1

1

13

High-throughput

0.489

High

1368801

CHM1A
Charged multivesicular body protein 1a

1

2

High-throughput

0.489

High

282285

SAP30
Histone deacetylase complex subunit SAP30

1

2

High-throughput

0.479

High

282761

E2F6
Transcription factor E2F6

1

6

Small-scale

0.479

High

519540

MYBB
Myb-related protein B

1

9

High-throughput

0.479

High

578524

BRAF
Serine/threonine-protein kinase B-raf

1

3

High-throughput

0.479

High

674278

BRD2
Bromodomain-containing protein 2

1

20

High-throughput

0.479

High

851624

GATA4
Transcription factor GATA-4

1

9

Small-scale

0.479

High

1146253

ZMY11
Zinc finger MYND domain-containing protein 11

1

20

Small-scale

0.479

High

1368788

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

1368793

PWP2A
PWWP domain-containing protein 2A

1

20

High-throughput

0.479

High

1197998

LIN52
Protein lin-52 homolog

1

0

High-throughput

0.458

High

332559

CCDB1
Cyclin-D1-binding protein 1

1

0

High-throughput

0.438

High

1193656

MAP9
Microtubule-associated protein 9

1

0

High-throughput

0.279

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025