HitPredict

Interactor 1: MPRIP (P97434)
Myosin phosphatase Rho-interacting protein (Rho-interacting protein 3) (RIP3) (p116Rip)
Gene: MPRIP

Interactor 2: LRRK2 (Q5S006)
Leucine-rich repeat serine/threonine-protein kinase 2 (EC 2.7.11.1) (EC 3.6.5.-)
Gene: LRRK2

Species: Mus musculus

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.33	1.00	0.575

Property	Details
Experiments	20876399
Identification Methods	anti bait coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0003779 - actin binding GO:0005737 - cytoplasm
Homologous interactions	13

Homologous interactions

Color coding for hit scores

	1 1024 Mm			1 2527
+	Hs
		1209297 MPRIP_HUMAN (1-1023): 8.31e-171: 528: 91.43		LRRK2_HUMAN (1-2527): 0: 2764: 86.60
+	Mm
		1209184 MYH9_MOUSE (280-1017): 9.31e-27: 120: 8.81		LRRK2_MOUSE (1-2527): 0: 2794: 100.00
+	Hs
		1209782 MYH2_HUMAN (292-1023): 6.71e-22: 104: 8.20		LRRK2_HUMAN (1-2527): 0: 2764: 86.60
+	Mm
		1209204 PLEC_MOUSE (500-1018): 5.77e-11: 69.2: 9.57		LRRK2_MOUSE (1-2527): 0: 2794: 100.00
+	Hs
		270815 ROCK2_HUMAN (475-1014): 3.88e-18: 92.4: 12.01		LRRK2_HUMAN (1-2527): 0: 2764: 86.60
+	Hs
		772841 MYH9_HUMAN (670-1018): 2.5e-13: 76.9: 12.82		LRRK2_HUMAN (1-2527): 0: 2764: 86.60
+	Hs
		1143147 PLEC_HUMAN (423-895): 5.47e-12: 72.6: 11.67		LRRK2_HUMAN (1-2527): 0: 2764: 86.60
+	Hs
		773198 MYH10_HUMAN (743-1024): 2.08e-11: 70.6: 12.72		LRRK2_HUMAN (1-2527): 0: 2764: 86.60
+	Hs
		1209322 MYH14_HUMAN (488-1012): 2.46e-10: 66.9: 15.02		LRRK2_HUMAN (1-2527): 0: 2764: 86.60
+	Hs
		213960 RB6I2_HUMAN (300-835): 1.93e-10: 67.1: 10.41		M3K7_HUMAN (1869-2143): 1.78e-23: 110: 30.14
+	Hs
		1038575 RB6I2_HUMAN (300-835): 1.93e-10: 67.1: 10.41		M3K10_HUMAN (1864-2136): 2.55e-22: 107: 32.54
+	Hs
		1182840 RB6I2_HUMAN (300-835): 1.93e-10: 67.1: 10.41		LRRK1_HUMAN (610-980): 8.96e-10: 67: 11.55
+	Hs
		1182856 CK5P2_HUMAN (677-993): 4.36e-09: 62.9: 20.12		LRRK1_HUMAN (610-980): 8.96e-10: 67: 11.55