HitPredict

Interactor 1: TIAM1 (Q13009)
Rho guanine nucleotide exchange factor TIAM1 (T-lymphoma invasion and metastasis-inducing protein 1) (TIAM-1)
Gene: TIAM1

Interactor 2: NEB2 (Q96SB3)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: PPP1R9B

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.50	1.00	0.713

Property	Details
Experiments	12531897
Identification Methods	two hybrid, affinity chromatography technology
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	PDZ~PDZ, PDZ~PDZ_5
Common GO terms	GO:0005886 - plasma membrane GO:0016477 - cell migration GO:0019900 - kinase binding GO:0032587 - ruffle membrane GO:0043025 - neuronal cell body
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 1591 Hs			1 817
+	Hs
		942336 TIAM1_HUMAN (1-1591): 0: 1876: 100.00		DLG4_HUMAN (438-714): 5.19e-28: 122: 16.38
+	Hs
		1021484 TIAM1_HUMAN (1-1591): 0: 1876: 100.00		DLG1_HUMAN (435-691): 6e-19: 94.1: 15.04
+	Hs
		1022438 TIAM1_HUMAN (1-1591): 0: 1876: 100.00		MAGI1_HUMAN (462-688): 1.9e-10: 66.9: 10.48
+	Dm
		113142 SIF2_DROME (385-1572): 0: 858: 34.28		M9NFI9_DROME (255-816): 1.29e-53: 204: 33.63
+	Mm
		1141818 ARHG2_MOUSE (821-1576): 9.13e-94: 329: 12.90		NEB2_MOUSE (1-817): 9.52e-117: 375: 96.21
+	Hs
		1066045 ARHG6_HUMAN (815-1591): 1.89e-88: 308: 16.08		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		1287792 Q96D37_HUMAN (954-1525): 1.68e-87: 306: 15.72		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Hs
		548744 VAV_HUMAN (954-1525): 4.75e-87: 306: 15.72		NEB2_HUMAN (1-817): 3.09e-122: 389: 100.00
+	Mm
		1141820 ARHG2_MOUSE (821-1576): 9.13e-94: 329: 12.90		Q7TN74_MOUSE (1-817): 5.32e-108: 358: 45.12
+	Mm
		57860 KALRN_MOUSE (799-1589): 1.81e-80: 297: 13.71		Q7TN74_MOUSE (1-817): 5.32e-108: 358: 45.12
+	Hs
		1016928 AKP13_HUMAN (646-1590): 1.94e-104: 373: 13.83		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Hs
		1049726 ARHG7_HUMAN (818-1568): 7.77e-97: 333: 14.38		ERBIN_HUMAN (11-583): 1.56e-42: 170: 13.02
+	Hs
		224720 KALRN_HUMAN (638-1589): 3.02e-81: 299: 13.06		RIMS1_HUMAN (126-637): 9e-45: 177: 17.41
+	Mm
		57820 KALRN_MOUSE (799-1589): 1.81e-80: 297: 13.71		H3BJA6_MOUSE (342-543): 3.63e-47: 169: 49.57
+	Hs
		224721 KALRN_HUMAN (638-1589): 3.02e-81: 299: 13.06		LNX1_HUMAN (273-773): 3.79e-34: 142: 13.78
+	Mm
		88351 D3YYY8_MOUSE (669-1455): 1.3e-90: 317: 12.25		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Mm
		57852 KALRN_MOUSE (799-1589): 1.81e-80: 297: 13.71		DLG4_MOUSE (438-714): 8.12e-28: 122: 16.38
+	Ce
		136804 VAV_CAEEL (963-1590): 6.88e-89: 315: 16.99		UNC89_CAEEL (2-312): 5.97e-20: 98.3: 14.29
+	Hs
		1049703 ARHG7_HUMAN (818-1568): 7.77e-97: 333: 14.38		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15
+	Hs
		1049952 ARHG6_HUMAN (815-1591): 1.89e-88: 308: 16.08		SCRIB_HUMAN (412-596): 5.32e-14: 78.7: 21.15