HitPredict

Interactor 1: CDK6 (Q00534)
Cyclin-dependent kinase 6 (EC 2.7.11.22) (Cell division protein kinase 6) (Serine/threonine-protein kinase PLSTIRE)
Gene: CDK6

Interactor 2: CDKL3 (Q8IVW4)
Cyclin-dependent kinase-like 3 (EC 2.7.11.22) (Serine/threonine-protein kinase NKIAMRE)
Gene: CDKL3

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	1.00	0.691

Property	Details
Experiments	23602568
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	Pkinase~Pkinase
Common GO terms	GO:0004693 - cyclin-dependent protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0106310 - protein serine kinase activity
Homologous interactions	18

Homologous interactions

Color coding for hit scores

	1 326 Hs			1 592
+	Hs
		667528 CDK2_HUMAN (10-311): 3.29e-147: 417: 47.39		CDK2_HUMAN (1-292): 1.61e-154: 446: 33.67
+	Hs
		667778 CDK6_HUMAN (1-326): 1.76e-146: 417: 100.00		CDK2_HUMAN (1-292): 1.61e-154: 446: 33.67
+	Hs
		667777 CDK2_HUMAN (10-311): 3.29e-147: 417: 47.39		CDK3_HUMAN (1-305): 1.34e-145: 424: 34.20
+	Hs
		1025320 CDK6_HUMAN (1-326): 1.76e-146: 417: 100.00		CDK5_HUMAN (1-292): 5.08e-137: 402: 34.35
+	Hs
		443189 CDK2_HUMAN (10-311): 3.29e-147: 417: 47.39		CDK1_HUMAN (1-291): 3.68e-137: 402: 35.37
+	Hs
		667779 CDK2_HUMAN (10-311): 3.29e-147: 417: 47.39		CDK5_HUMAN (1-292): 5.08e-137: 402: 34.35
+	Hs
		1025251 CDK3_HUMAN (10-313): 9.26e-139: 396: 45.78		CDK5_HUMAN (1-292): 5.08e-137: 402: 34.35
+	Hs
		443308 CDK3_HUMAN (10-313): 9.26e-139: 396: 45.78		CDK1_HUMAN (1-291): 3.68e-137: 402: 35.37
+	At
		1183666 MPK4_ARATH (6-322): 5.82e-134: 387: 32.82		MPK4_ARATH (7-319): 7.36e-134: 397: 29.15
+	Zm
		1734 A0A096S009_MAIZE (10-324): 3.86e-127: 377: 30.77		A0A096S009_MAIZE (2-513): 5.57e-133: 402: 23.45
+	At
		1183568 MPK3_ARATH (5-322): 8.77e-132: 381: 33.03		CDKC2_ARATH (1-453): 1.43e-130: 394: 23.36
+	Hs
		443120 CDK1_HUMAN (10-305): 7.44e-130: 373: 45.18		CDK1_HUMAN (1-291): 3.68e-137: 402: 35.37
+	At
		1183610 MPK3_ARATH (5-322): 8.77e-132: 381: 33.03		CDKC1_ARATH (1-439): 1.86e-130: 393: 24.95
+	At
		1183430 MPK6_ARATH (7-323): 4.96e-129: 375: 33.54		MPK2_ARATH (3-324): 2.35e-131: 390: 29.88
+	Hs
		667657 CDK2_HUMAN (10-311): 3.29e-147: 417: 47.39		CDK7_HUMAN (4-287): 7.33e-53: 186: 34.01
+	Hs
		897236 CDK6_HUMAN (1-326): 1.76e-146: 417: 100.00		CDK7_HUMAN (4-287): 7.33e-53: 186: 34.01
+	Hs
		667930 CDK2_HUMAN (10-311): 3.29e-147: 417: 47.39		CDK20_HUMAN (1-286): 3.4e-51: 181: 34.95
+	Hs
		443269 CDK1_HUMAN (10-305): 7.44e-130: 373: 45.18		CDK7_HUMAN (4-287): 7.33e-53: 186: 34.01