HitPredict

Interactor 1: MP2K5 (Q13163)
Dual specificity mitogen-activated protein kinase kinase 5 (MAP kinase kinase 5) (MAPKK 5) (EC 2.7.12.2) (MAPK/ERK kinase 5) (MEK 5)
Gene: MAP2K5

Interactor 2: LATS2 (Q9NRM7)
Serine/threonine-protein kinase LATS2 (EC 2.7.11.1) (Kinase phosphorylated during mitosis protein) (Large tumor suppressor homolog 2) (Serine/threonine-protein kinase kpm) (Warts-like kinase)
Gene: LATS2

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	1.00	0.647

Property	Details
Experiments	28205554
Identification Methods	fluorescent resonance energy transfer
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	PB1~Pkinase, Pkinase~Pkinase, Pkinase~Pkinase_C
Common GO terms	GO:0004674 - protein serine/threonine kinase activity GO:0005524 - ATP binding GO:0046872 - metal ion binding GO:0106310 - protein serine kinase activity
Homologous interactions	17

Homologous interactions

Color coding for hit scores

	1 448 Hs			1 1088
+	Hs
		682034 AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		160800 AURKA_HUMAN (67-439): 1.27e-122: 364: 21.12		LATS2_HUMAN (1-1088): 0: 983: 100.00
+	Hs
		681821 MP2K5_HUMAN (1-448): 4.77e-153: 443: 100.00		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		681681 AKT2_HUMAN (111-442): 5.15e-125: 373: 20.86		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		682218 AKT2_HUMAN (111-442): 5.15e-125: 373: 20.86		AKT3_HUMAN (532-1043): 3.66e-141: 435: 22.01
+	Hs
		682081 AKT3_HUMAN (111-444): 6.73e-124: 370: 20.34		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Mm
		682096 AKT1_MOUSE (59-444): 7.18e-124: 370: 17.57		AKT1_MOUSE (532-1043): 5.78e-141: 434: 22.16
+	Hs
		681680 AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		160403 AURKA_HUMAN (67-439): 1.27e-122: 364: 21.12		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Hs
		681915 MARK2_HUMAN (113-445): 4.08e-116: 359: 20.59		AKT1_HUMAN (532-1043): 2.2e-141: 435: 22.16
+	Mm
		554867 AKT1_MOUSE (59-444): 7.18e-124: 370: 17.57		KPCE_MOUSE (554-1010): 2.84e-130: 415: 29.92
+	Hs
		568561 AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		969093 MARK2_HUMAN (113-445): 4.08e-116: 359: 20.59		KPCE_HUMAN (554-1010): 1.06e-129: 413: 29.92
+	Hs
		568551 MARK3_HUMAN (113-430): 1.45e-116: 359: 20.49		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		568714 MARK2_HUMAN (113-445): 4.08e-116: 359: 20.59		KAPCA_HUMAN (635-1024): 1.31e-133: 410: 31.73
+	Hs
		1026844 MP2K5_HUMAN (1-448): 4.77e-153: 443: 100.00		MRCKB_HUMAN (658-1007): 1.11e-70: 261: 40.34
+	Hs
		681859 AKT1_HUMAN (59-444): 3.89e-123: 368: 17.82		KS6A1_HUMAN (519-977): 1.47e-79: 277: 20.34