HitPredict

Interactor 1: STK3 (Q13188)
Serine/threonine-protein kinase 3 (EC 2.7.11.1) (Mammalian STE20-like protein kinase 2) (MST-2) (STE20-like kinase MST2) (Serine/threonine-protein kinase Krs-1) [Cleaved into: Serine/threonine-protein kinase 3 36kDa subunit (MST2/N); Serine/threonine-protein kinase 3 20kDa subunit (MST2/C)]
Gene: STK3

Interactor 2: PKHA4 (Q9H4M7)
Pleckstrin homology domain-containing family A member 4 (PH domain-containing family A member 4) (Phosphoinositol 3-phosphate-binding protein 1) (PEPP-1)
Gene: PLEKHA4

Species: Homo sapiens

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.618

Property	Details
Experiments	31091453
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	PH~Pkinase
Common GO terms	GO:0005737 - cytoplasm
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 491 Hs			1 779
+	Hs
		1023113 STK4_HUMAN (6-491): 3.63e-151: 441: 75.57		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		682210 AKT2_HUMAN (3-338): 1.43e-134: 399: 22.35		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1331766 STK24_HUMAN (16-325): 6.03e-124: 370: 50.32		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		131607 STK25_HUMAN (9-426): 4.69e-123: 368: 40.28		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1331504 STK26_HUMAN (22-392): 4.24e-122: 364: 44.27		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1026227 PAK1_HUMAN (6-302): 2.26e-118: 359: 41.81		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		850712 KS6A3_HUMAN (22-297): 8.86e-98: 312: 28.42		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1331724 M4K5_HUMAN (1-345): 1.89e-74: 252: 39.94		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1233543 MINK1_HUMAN (5-316): 3.34e-70: 244: 43.43		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1331590 TNIK_HUMAN (6-303): 4.21e-70: 244: 44.03		PKHA4_HUMAN (1-779): 4.1e-157: 477: 100.00
+	Hs
		1027413 STK3_HUMAN (1-491): 1.83e-172: 496: 100.00		CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84
+	Hs
		1023089 STK4_HUMAN (6-491): 3.63e-151: 441: 75.57		CNKR1_HUMAN (17-260): 6.93e-38: 153: 22.84
+	Sc
		419871 SNF1_YEAST (26-422): 1.11e-116: 358: 23.29		OSH3_YEAST (21-718): 7.21e-65: 235: 11.98
+	Mm
		1194491 MINK1_MOUSE (5-316): 4.46e-71: 247: 43.73		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Mm
		949351 TNIK_MOUSE (6-303): 2.2e-70: 245: 44.03		CNKR2_MOUSE (1-468): 7.51e-48: 185: 14.40
+	Hs
		1263851 TNIK_HUMAN (6-303): 4.21e-70: 244: 44.03		CNKR2_HUMAN (1-468): 1.39e-46: 181: 13.77
+	Mm
		949314 TNIK_MOUSE (6-303): 2.2e-70: 245: 44.03		RHG21_MOUSE (22-626): 1.41e-38: 157: 14.13
+	Mm
		93677 TNIK_MOUSE (6-303): 2.2e-70: 245: 44.03		E9Q6H8_MOUSE (2-527): 2.62e-38: 156: 19.44
+	Hs
		1018193 M4K2_HUMAN (14-310): 3.14e-73: 249: 42.11		PKHA5_HUMAN (2-653): 1.62e-36: 150: 17.61
+	Mm
		949327 TNIK_MOUSE (6-303): 2.2e-70: 245: 44.03		Q6ZPK1_MOUSE (2-527): 4.76e-37: 152: 19.44