HitPredict

Interactor 1: CBLB (Q13191)
E3 ubiquitin-protein ligase CBL-B (EC 2.3.2.27) (Casitas B-lineage lymphoma proto-oncogene b) (RING finger protein 56) (RING-type E3 ubiquitin transferase CBL-B) (SH3-binding protein CBL-B) (Signal transduction protein CBL-B)
Gene: CBLB

Interactor 2: CD2AP (Q9Y5K6)
CD2-associated protein (Adapter protein CMS) (Cas ligand with multiple SH3 domains)
Gene: CD2AP

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.71	0.60	0.654

Property	Details
Experiments	23663663, 17020880
Identification Methods	pull down, x-ray crystallography, affinity chromatography technology, anti bait coimmunoprecipitation, nuclear magnetic resonance, isothermal titration calorimetry, anti tag coimmunoprecipitation
Interaction Type	direct interaction, association, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0007165 - signal transduction GO:0017124 - SH3 domain binding GO:0030163 - protein catabolic process GO:0050852 - T cell receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 982 Hs			1 639
+	Hs
		1027621 CBLB_HUMAN (1-982): 0: 877: 100.00		SH3K1_HUMAN (1-638): 3.71e-91: 297: 32.43
+	Hs
		209046 CBLB_HUMAN (1-982): 0: 877: 100.00		NCK2_HUMAN (2-361): 2.2e-59: 205: 16.17
+	Mm
		223012 CBLB_MOUSE (1-982): 0: 873: 95.12		NCK2_MOUSE (2-361): 1.08e-58: 203: 16.58
+	Hs
		275194 CBLB_HUMAN (1-982): 0: 877: 100.00		GRAP2_HUMAN (2-329): 1.68e-45: 166: 12.83
+	Mm
		292684 CBLB_MOUSE (1-982): 0: 873: 95.12		GRAP2_MOUSE (2-328): 2.38e-46: 168: 15.27
+	Hs
		924539 CBLB_HUMAN (1-982): 0: 877: 100.00		GRB2_HUMAN (112-328): 1.9e-40: 148: 18.27
+	Mm
		1112053 CBLB_MOUSE (1-982): 0: 873: 95.12		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Mm
		82735 B9EKI5_MOUSE (1-982): 0: 852: 90.53		GRB2_MOUSE (112-328): 1.43e-40: 149: 18.27
+	Hs
		557678 CBLB_HUMAN (1-982): 0: 877: 100.00		NCK1_HUMAN (113-378): 9.79e-21: 96.5: 14.24
+	Hs
		298976 CBLB_HUMAN (1-982): 0: 877: 100.00		SRBS2_HUMAN (6-215): 1e-18: 92.7: 18.40
+	Mm
		1112057 CBLB_MOUSE (1-982): 0: 873: 95.12		SRBS1_MOUSE (58-326): 2.72e-19: 94.7: 17.93
+	Hs
		1027604 CBLB_HUMAN (1-982): 0: 877: 100.00		ARHG7_HUMAN (176-378): 4.79e-13: 74.6: 20.87
+	Hs
		235501 CBLB_HUMAN (1-982): 0: 877: 100.00		VINEX_HUMAN (163-343): 4.52e-13: 74.2: 18.28
+	Mm
		82738 B9EKI5_MOUSE (1-982): 0: 852: 90.53		NCK1_MOUSE (113-378): 6.4e-21: 97.3: 14.24
+	Hs
		1027627 CBLB_HUMAN (1-982): 0: 877: 100.00		ITSN2_HUMAN (1-63): 2.7e-12: 72.2: 34.92
+	Mm
		1112077 CBLB_MOUSE (1-982): 0: 873: 95.12		ARHG7_MOUSE (230-378): 9.82e-13: 73.4: 26.17
+	Hs
		1027606 CBLB_HUMAN (1-982): 0: 877: 100.00		ITSN1_HUMAN (1-55): 3.97e-11: 68.8: 43.64
+	Mm
		1112081 CBLB_MOUSE (1-982): 0: 873: 95.12		ITSN2_MOUSE (1-63): 9.2e-12: 70.7: 34.92
+	Hs
		47590 CBL_HUMAN (25-976): 0: 675: 47.10		A0A8V8TNS8_HUMAN (1-416): 2.27e-70: 236: 37.21
+	Dm
		112567 O46034_DROME (27-434): 0: 718: 71.39		M9ND00_DROME (213-549): 1.1e-13: 76.9: 11.30