HitPredict

Interactor 1: MDM2 (Q00987)
E3 ubiquitin-protein ligase Mdm2 (EC 2.3.2.27) (Double minute 2 protein) (Hdm2) (Oncoprotein Mdm2) (RING-type E3 ubiquitin transferase Mdm2) (p53-binding protein Mdm2)
Gene: MDM2

Interactor 2: UBP25 (Q9UHP3)
Ubiquitin carboxyl-terminal hydrolase 25 (EC 3.4.19.12) (Deubiquitinating enzyme 25) (USP on chromosome 21) (Ubiquitin thioesterase 25) (Ubiquitin-specific-processing protease 25)
Gene: USP25

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	0.60	0.479

Property	Details
Experiments	37480689
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0005829 - cytosol GO:0031625 - ubiquitin protein ligase binding GO:0043130 - ubiquitin binding
Homologous interactions	10

Homologous interactions

Color coding for hit scores

	1 491 Hs			1 1055
+	Hs
		1028266 MDM2_HUMAN (1-491): 0: 710: 100.00		UBP48_HUMAN (157-406): 1.38e-66: 245: 25.86
+	Hs
		1028324 MDM2_HUMAN (1-491): 0: 710: 100.00		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78
+	Hs
		288392 MDM2_HUMAN (1-491): 0: 710: 100.00		UBP2_HUMAN (514-655): 1.22e-14: 80.4: 18.31
+	Hs
		1028400 MDM2_HUMAN (1-491): 0: 710: 100.00		UBP42_HUMAN (560-685): 5.39e-11: 69.2: 20.31
+	Hs
		275885 MDM2_HUMAN (1-491): 0: 710: 100.00		UBP12_HUMAN (465-658): 2.29e-09: 62.6: 16.83
+	Mm
		662976 MDM2_MOUSE (1-490): 0: 639: 80.24		UBP7_MOUSE (547-758): 7.25e-18: 91.4: 22.22
+	Hs
		179749 MDM4_HUMAN (4-489): 0: 531: 32.08		UBP22_HUMAN (460-661): 1.14e-19: 96.1: 17.82
+	Hs
		179733 MDM4_HUMAN (4-489): 0: 531: 32.08		UBP7_HUMAN (547-758): 1.63e-17: 90.2: 21.78
+	Mm
		205236 MDM4_MOUSE (4-489): 0: 522: 32.36		UBP7_MOUSE (547-758): 7.25e-18: 91.4: 22.22
+	Hs
		179653 MDM4_HUMAN (4-489): 0: 531: 32.08		UBP2_HUMAN (514-655): 1.22e-14: 80.4: 18.31