HitPredict

Interactor 1: TIF1B (Q13263)
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-associated protein 1) (KAP-1) (KRAB-interacting protein 1) (KRIP-1) (Nuclear corepressor KAP-1) (RING finger protein 96) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)
Gene: TRIM28

Interactor 2: SENP7 (Q9BQF6)
Sentrin-specific protease 7 (EC 3.4.22.-) (SUMO-1-specific protease 2) (Sentrin/SUMO-specific protease SENP7)
Gene: SENP7

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	27705803, 24018422
Identification Methods	affinity chromatography technology, enzymatic study, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, direct interaction, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005634 - nucleus
Homologous interactions	9

Homologous interactions

Color coding for hit scores

	1 835 Hs			1 1050
+	Hs
		1029868 TIF1B_HUMAN (18-835): 3.77e-174: 525: 100.00		SENP3_HUMAN (629-965): 5.55e-74: 257: 12.47
+	Hs
		669029 PML_HUMAN (29-609): 1.21e-57: 214: 14.00		SENP1_HUMAN (621-965): 7.85e-89: 300: 14.68
+	Hs
		668992 PML_HUMAN (29-609): 1.21e-57: 214: 14.00		SENP2_HUMAN (599-965): 7.51e-89: 299: 13.44
+	Hs
		1282046 TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56		SENP2_HUMAN (599-965): 7.51e-89: 299: 13.44
+	Hs
		164494 TRI66_HUMAN (335-810): 2.93e-45: 178: 19.00		SENP1_HUMAN (621-965): 7.85e-89: 300: 14.68
+	Hs
		668982 PML_HUMAN (29-609): 1.21e-57: 214: 14.00		SENP3_HUMAN (629-965): 5.55e-74: 257: 12.47
+	Hs
		1282040 TRI63_HUMAN (53-406): 8.26e-61: 211: 15.56		SENP3_HUMAN (629-965): 5.55e-74: 257: 12.47
+	Hs
		668908 PML_HUMAN (29-609): 1.21e-57: 214: 14.00		SENP5_HUMAN (591-965): 1.31e-55: 209: 11.72
+	Hs
		668962 PML_HUMAN (29-609): 1.21e-57: 214: 14.00		SENP6_HUMAN (911-1046): 1.23e-35: 149: 53.68