HitPredict

Interactor 1: PIAS2 (O75928)
E3 SUMO-protein ligase PIAS2 (EC 2.3.2.-) (Androgen receptor-interacting protein 3) (ARIP3) (DAB2-interacting protein) (DIP) (E3 SUMO-protein transferase PIAS2) (Msx-interacting zinc finger protein) (Miz1) (PIAS-NY protein) (Protein inhibitor of activated STAT x) (Protein inhibitor of activated STAT2)
Gene: PIAS2

Interactor 2: NAV2 (Q8IVL1)
Neuron navigator 2 (EC 3.6.4.12) (Helicase APC down-regulated 1) (Pore membrane and/or filament-interacting-like protein 2) (Retinoic acid inducible in neuroblastoma 1) (Steerin-2) (Unc-53 homolog 2) (unc53H2)
Gene: NAV2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.69	0.60	0.646

Property	Details
Experiments	25416956, 16189514
Identification Methods	two hybrid, two hybrid prey pooling approach, two hybrid array, validated two hybrid, two hybrid pooling approach
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm
Homologous interactions	8

Homologous interactions

Color coding for hit scores

	1 621 Hs			1 2488
+	Hs
		278081 PIAS1_HUMAN (1-621): 0: 653: 54.10		FLNC_HUMAN (51-2016): 4.72e-131: 464: 9.74
+	Hs
		261165 PIAS1_HUMAN (1-621): 0: 653: 54.10		FLNB_HUMAN (70-1944): 5.47e-122: 435: 9.92
+	Hs
		277933 PIAS1_HUMAN (1-621): 0: 653: 54.10		FLNA_HUMAN (64-1900): 4.31e-116: 416: 10.76
+	Hs
		278089 PIAS1_HUMAN (1-621): 0: 653: 54.10		PLEC_HUMAN (2-322): 2.96e-74: 279: 15.46
+	Hs
		277910 PIAS1_HUMAN (1-621): 0: 653: 54.10		ACTN1_HUMAN (60-309): 3.46e-72: 264: 17.12
+	Hs
		278053 PIAS1_HUMAN (1-621): 0: 653: 54.10		SPTB2_HUMAN (60-303): 5.64e-57: 222: 16.80
+	Hs
		211442 PIAS1_HUMAN (1-621): 0: 653: 54.10		ACTN4_HUMAN (84-187): 4.26e-30: 132: 29.81
+	Hs
		521575 PIAS4_HUMAN (2-499): 1.7e-172: 502: 43.32		ACTN1_HUMAN (60-309): 3.46e-72: 264: 17.12