HitPredict

Interactor 1: CTBP1 (Q13363)
C-terminal-binding protein 1 (CtBP1) (EC 1.1.1.-)
Gene: CTBP1

Interactor 2: HIC1 (Q14526)
Hypermethylated in cancer 1 protein (Hic-1) (Zinc finger and BTB domain-containing protein 29)
Gene: HIC1

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.64	0.60	0.620

Property	Details
Experiments	19486893, 16762039
Identification Methods	two hybrid, affinity chromatography technology, anti bait coimmunoprecipitation
Interaction Type	direct interaction, physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0000122 - negative regulation of transcription by RNA polymerase II GO:0005634 - nucleus GO:0005654 - nucleoplasm GO:0006357 - regulation of transcription by RNA polymerase II
Homologous interactions	5

Homologous interactions

Color coding for hit scores

	1 440 Hs			1 733
+	Hs
		881174 CTBP2_HUMAN (10-439): 0: 538: 80.23		HIC1_HUMAN (1-733): 0: 608: 100.00
+	Hs
		1032555 CTBP1_HUMAN (1-440): 0: 547: 100.00		HIC2_HUMAN (23-615): 6.37e-156: 467: 46.35
+	Hs
		881255 CTBP2_HUMAN (10-439): 0: 538: 80.23		HIC2_HUMAN (23-615): 6.37e-156: 467: 46.35
+	Hs
		1343652 GRHPR_HUMAN (12-348): 1.18e-111: 333: 24.78		PRDM9_HUMAN (167-651): 6.38e-145: 448: 17.15
+	Hs
		881179 CTBP2_HUMAN (10-439): 0: 538: 80.23		ZNF79_HUMAN (273-628): 2.66e-71: 242: 21.57