Protein: OTUD5
OTU domain-containing protein 5 (EC 3.4.19.12) (Deubiquitinating enzyme A) (DUBA)

Gene: OTUD5
Organism: Homo sapiens
Interactions: 48
UniProt ID: Q96G74

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0006508 - proteolysis
GO:0014033 - neural crest cell differentiation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508434

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

10

11

Small-scale

0.972

High

639291

TNAP3
Tumor necrosis factor alpha-induced protein 3

2

4

High-throughput

0.811

High

1352098

OTU7A
OTU domain-containing protein 7A

1

4

High-throughput

0.691

High

414400

P53
Cellular tumor antigen p53

3

3

Small-scale

0.690

High

1154904

NEDD8
Ubiquitin-like protein NEDD8

1

4

Small-scale

0.647

High

1391428

RABX5
Rab5 GDP/GTP exchange factor

2

1

High-throughput

0.628

High

1391429

TRI35
E3 ubiquitin-protein ligase TRIM35

2

3

High-throughput

0.628

High

1391426

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

1

Small-scale

0.611

High

705509

GRN
Progranulin

3

1

High-throughput

0.609

High

1094955

TRAF3
TNF receptor-associated factor 3

2

7

Small-scale

0.601

High

1391419

OTUD5
OTU domain-containing protein 5

1

7

High-throughput

0.575

High

325982

UBR5
E3 ubiquitin-protein ligase UBR5

1

7

Small-scale

0.561

High

723049

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

1

Small-scale

0.561

High

1065358

SSRP1
FACT complex subunit SSRP1

1

1

Small-scale

0.561

High

1144438

NONO
Non-POU domain-containing octamer-binding protein

1

10

Small-scale

0.561

High

162371

PDCD5
Programmed cell death protein 5

1

0

Small-scale

0.549

High

621711

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

Small-scale

0.537

High

667404

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

Small-scale

0.537

High

925963

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

Small-scale

0.537

High

1391430

SP16H
FACT complex subunit SPT16

1

0

Small-scale

0.537

High

347246

BAG2
BAG family molecular chaperone regulator 2

1

2

High-throughput

0.536

High

637682

FLNA
Filamin-A

1

8

High-throughput

0.536

High

687850

SYVC
Valine--tRNA ligase

1

5

High-throughput

0.536

High

720889

KPYR
Pyruvate kinase PKLR

1

1

High-throughput

0.536

High

907535

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

1

3

High-throughput

0.536

High

931059

HSP72
Heat shock-related 70 kDa protein 2

1

1

High-throughput

0.536

High

1029358

SET
Protein SET

1

2

High-throughput

0.536

High

1391422

CYBP
Calcyclin-binding protein

1

1

High-throughput

0.536

High

1391423

PYRG2
CTP synthase 2

1

1

High-throughput

0.536

High

1391424

LANC2
LanC-like protein 2

1

1

High-throughput

0.536

High

568689

GYS1
Glycogen [starch] synthase, muscle

1

0

High-throughput

0.513

High

788328

GPX4
Phospholipid hydroperoxide glutathione peroxidase GPX4

1

0

High-throughput

0.513

High

987856

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.513

High

1168949

LONF2
LON peptidase N-terminal domain and RING finger protein 2

1

1

High-throughput

0.489

High

170279

AURKA
Aurora kinase A

1

11

Small-scale

0.479

High

728380

AKT1
RAC-alpha serine/threonine-protein kinase

1

3

Small-scale

0.479

High

951807

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

3

Small-scale

0.479

High

1323128

CCAR2
Cell cycle and apoptosis regulator protein 2

1

2

Small-scale

0.479

High

1391420

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

696200

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

1244815

FBX38
F-box only protein 38

1

0

High-throughput

0.458

High

1292860

STING
Stimulator of interferon genes protein

1

0

Small-scale

0.458

High

1391425

RN146
E3 ubiquitin-protein ligase RNF146

1

0

Small-scale

0.458

High

1391421

LN28A
Protein lin-28 homolog A

1

5

High-throughput

0.445

High

179550

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.438

High

1391427

DS13B
Dual specificity protein phosphatase 13B

1

2

High-throughput

0.437

High

1331419

MB213
Protein mab-21-like 3

1

1

High-throughput

0.407

High


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Last updated: 11Aug2025