Protein: OTU6A
OTU domain-containing protein 6A (EC 3.4.19.12) (DUBA-2)

Gene: OTU6A, OTUD6A
Organism: Homo sapiens
Interactions: 32
UniProt ID: Q7L8S5

Gene Ontology (top 5):
GO:0004843 - cysteine-type deubiquitinase activity
GO:0006508 - proteolysis
GO:0035523 - protein K29-linked deubiquitination
GO:0035871 - protein K11-linked deubiquitination
GO:1990167 - protein K27-linked deubiquitination

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

508193

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

8

Small-scale

0.579

High

553753

MYCL
Protein L-Myc

2

2

High-throughput

0.553

High

789150

NUP62
Nuclear pore glycoprotein p62

2

1

High-throughput

0.553

High

991590

DYL1
Dynein light chain 1, cytoplasmic

2

1

High-throughput

0.553

High

1048223

EMX2
Homeobox protein EMX2

2

3

High-throughput

0.553

High

1123257

DPYL3
Dihydropyrimidinase-related protein 3

2

1

High-throughput

0.553

High

1273057

DYL2
Dynein light chain 2, cytoplasmic

2

1

High-throughput

0.553

High

1273058

P121A
Nuclear envelope pore membrane protein POM 121

2

2

High-throughput

0.553

High

1273063

TRIM7
E3 ubiquitin-protein ligase TRIM7

2

3

High-throughput

0.553

High

1273066

PDLI7
PDZ and LIM domain protein 7

2

1

High-throughput

0.553

High

1273054

TRI46
Tripartite motif-containing protein 46

1

8

High-throughput

0.439

High

1273060

RING2
E3 ubiquitin-protein ligase RING2

1

7

High-throughput

0.439

High

1273062

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

1

High-throughput

0.439

High

1273064

TRIM5
Tripartite motif-containing protein 5

1

3

High-throughput

0.439

High

1273065

TRI39
E3 ubiquitin-protein ligase TRIM39

1

3

High-throughput

0.439

High

170210

AURKA
Aurora kinase A

1

9

Small-scale

0.437

High

251608

CCNT1
Cyclin-T1

1

2

Small-scale

0.437

High

325909

UBR5
E3 ubiquitin-protein ligase UBR5

1

4

Small-scale

0.437

High

372404

MYC
Myc proto-oncogene protein

1

2

Small-scale

0.437

High

717879

2AAA
Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform

1

1

Small-scale

0.437

High

977531

PP2AB
Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform

1

2

Small-scale

0.437

High

994277

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

2

Small-scale

0.437

High

1039527

TOP2B
DNA topoisomerase 2-beta

1

1

Small-scale

0.437

High

1191537

TBRG1
Transforming growth factor beta regulator 1

1

1

High-throughput

0.437

High

1273059

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

1

Small-scale

0.437

High

1273061

GPR21
Probable G-protein coupled receptor 21

2

0

High-throughput

0.328

High

1048575

SSBP
Single-stranded DNA-binding protein, mitochondrial

2

0

High-throughput

0.316

High

1273055

VPS52
Vacuolar protein sorting-associated protein 52 homolog

2

0

High-throughput

0.316

High

563976

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.282

High

1273067

CBLC
E3 ubiquitin-protein ligase CBL-C

1

0

High-throughput

0.251

Low

135642

DNM1L
Dynamin-1-like protein

1

0

Small-scale

0.249

Low

1273056

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025