HitPredict

Interactor 1: SQSTM (Q13501)
Sequestosome-1 (EBI3-associated protein of 60 kDa) (EBIAP) (p60) (Phosphotyrosine-independent ligand for the Lck SH2 domain of 62 kDa) (Ubiquitin-binding protein p62)
Gene: SQSTM1

Interactor 2: MLP3C (Q9BXW4)
Microtubule-associated proteins 1A/1B light chain 3C (Autophagy-related protein LC3 C) (Autophagy-related ubiquitin-like modifier LC3 C) (MAP1 light chain 3-like protein 3) (MAP1A/MAP1B light chain 3 C) (MAP1A/MAP1B LC3 C) (Microtubule-associated protein 1 light chain 3 gamma)
Gene: MAP1LC3C

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.95	0.60	0.755

Property	Details
Experiments	29426817, 31006538, 34929165, 29149599, 37219487, 31286822, 19250911, 23022382, 33436498, 24668264, 20562859, 34799561
Identification Methods	pull down, affinity chromatography technology, unspecified method, proximity labelling technology, fluorescence polarization spectroscopy, anti tag coimmunoprecipitation, phage display
Interaction Type	direct interaction, physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005776 - autophagosome GO:0005829 - cytosol GO:0016236 - macroautophagy GO:0031625 - ubiquitin protein ligase binding GO:0035973 - aggrephagy
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 440 Hs			1 147
+	Hs
		1036661 SQSTM_HUMAN (1-440): 0: 760: 100.00		Q6IAW1_HUMAN (13-127): 3.44e-54: 168: 38.26
+	Hs
		306157 SQSTM_HUMAN (1-440): 0: 760: 100.00		GBRAP_HUMAN (13-127): 3.44e-54: 168: 38.26
+	Hs
		891130 SQSTM_HUMAN (1-440): 0: 760: 100.00		GBRL2_HUMAN (13-126): 1.65e-54: 168: 42.98
+	Hs
		1036900 SQSTM_HUMAN (1-440): 0: 760: 100.00		MLP3A_HUMAN (7-126): 2.49e-53: 165: 59.17
+	Hs
		1036882 SQSTM_HUMAN (1-440): 0: 760: 100.00		MLP3B_HUMAN (7-127): 8.15e-53: 164: 54.55
+	Hs
		1036891 SQSTM_HUMAN (1-440): 0: 760: 100.00		GBRL1_HUMAN (13-126): 4.75e-52: 162: 39.47
+	Hs
		61895 SQSTM_HUMAN (1-440): 0: 760: 100.00		MP3B2_HUMAN (7-127): 1.01e-51: 162: 53.72
+	Mm
		1145358 SQSTM_MOUSE (1-440): 0: 731: 90.72		MLP3A_MOUSE (7-126): 2.49e-53: 165: 59.17
+	Mm
		1145362 SQSTM_MOUSE (1-440): 0: 731: 90.72		MLP3B_MOUSE (7-126): 6.48e-53: 165: 55.00
+	Hs
		306226 MIB1_HUMAN (105-233): 3.47e-43: 164: 25.19		GBRAP_HUMAN (13-127): 3.44e-54: 168: 38.26
+	Ce
		94010 F1LIM5_CAEEL (79-220): 6.58e-30: 124: 22.70		LGG1_CAEEL (12-126): 1.46e-52: 164: 38.26
+	Hs
		1056120 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		MLP3C_HUMAN (1-147): 4.64e-72: 214: 100.00
+	Ce
		94015 F1LIM5_CAEEL (79-220): 6.58e-30: 124: 22.70		LGG2_CAEEL (10-126): 1.88e-44: 143: 47.01
+	Dm
		536028 REF2P_DROME (107-170): 7.35e-20: 94: 36.92		Q9W2S2_DROME (13-127): 6.14e-55: 170: 37.39
+	Hs
		320003 HERC2_HUMAN (120-197): 2.6e-12: 71.3: 32.50		MLP3B_HUMAN (7-127): 8.15e-53: 164: 54.55
+	Hs
		306175 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		GBRAP_HUMAN (13-127): 3.44e-54: 168: 38.26
+	Hs
		891147 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		GBRL2_HUMAN (13-126): 1.65e-54: 168: 42.98
+	Hs
		1056129 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		MLP3A_HUMAN (7-126): 2.49e-53: 165: 59.17
+	Hs
		1056123 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		MLP3B_HUMAN (7-127): 8.15e-53: 164: 54.55
+	Hs
		1056126 NBR1_HUMAN (80-184): 5.95e-10: 63.6: 24.78		GBRL1_HUMAN (13-126): 4.75e-52: 162: 39.47