HitPredict

Interactor 1: CUL2 (Q13617)
Cullin-2 (CUL-2)
Gene: CUL2

Interactor 2: KLDC2 (Q9Y2U9)
Kelch domain-containing protein 2 (Hepatocellular carcinoma-associated antigen 33) (Host cell factor homolog LCP) (Host cell factor-like protein 1) (HCLP-1)
Gene: KLHDC2

Species: Homo sapiens

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.85	0.60	0.718

Property	Details
Experiments	28514442, 33961781, 36805027, 18187417, 21145461
Identification Methods	affinity chromatography technology, tandem affinity purification, anti tag coimmunoprecipitation
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0016567 - protein ubiquitination GO:0031462 - Cul2-RING ubiquitin ligase complex GO:0140627 - ubiquitin-dependent protein catabolic process via the C-end degron rule pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 745 Hs			1 406
+	Hs
		1041366 CUL2_HUMAN (1-745): 0: 840: 100.00		KLD10_HUMAN (139-399): 2.36e-38: 145: 17.84
+	Hs
		299515 CUL3_HUMAN (1-745): 0: 768: 26.38		KLH18_HUMAN (87-405): 5.72e-60: 206: 15.85
+	Hs
		1041317 CUL2_HUMAN (1-745): 0: 840: 100.00		KEAP1_HUMAN (226-406): 5.71e-30: 123: 15.76
+	Hs
		1041449 CUL2_HUMAN (1-745): 0: 840: 100.00		KLDC3_HUMAN (5-195): 2.91e-29: 119: 16.58
+	Hs
		1043281 CUL4A_HUMAN (4-745): 0: 773: 26.86		KLHL3_HUMAN (165-400): 3.41e-45: 166: 14.41
+	Hs
		848213 CUL3_HUMAN (1-745): 0: 768: 26.38		HCFC1_HUMAN (1-302): 6.46e-41: 157: 17.43
+	Hs
		1041189 CUL1_HUMAN (6-745): 0: 775: 36.24		KLHL4_HUMAN (228-405): 1.02e-31: 129: 15.17
+	Hs
		1043103 CUL4A_HUMAN (4-745): 0: 773: 26.86		LZTR1_HUMAN (162-401): 1.73e-32: 131: 13.83
+	Hs
		1040975 CUL1_HUMAN (6-745): 0: 775: 36.24		KEAP1_HUMAN (226-406): 5.71e-30: 123: 15.76
+	Hs
		1042971 CUL4A_HUMAN (4-745): 0: 773: 26.86		KEAP1_HUMAN (226-406): 5.71e-30: 123: 15.76
+	Hs
		1041547 CUL3_HUMAN (1-745): 0: 768: 26.38		KEAP1_HUMAN (226-406): 5.71e-30: 123: 15.76
+	Mm
		1337550 CUL3_MOUSE (1-745): 0: 768: 26.50		KEAP1_MOUSE (226-406): 3.36e-29: 121: 15.22
+	Hs
		1041022 CUL1_HUMAN (6-745): 0: 775: 36.24		KLH12_HUMAN (6-156): 1.27e-25: 110: 16.56
+	Hs
		1043391 CUL4B_HUMAN (4-745): 0: 771: 27.79		KLH12_HUMAN (6-156): 1.27e-25: 110: 16.56
+	Hs
		1041712 CUL3_HUMAN (1-745): 0: 768: 26.38		KLH12_HUMAN (6-156): 1.27e-25: 110: 16.56
+	Hs
		1041048 CUL1_HUMAN (6-745): 0: 775: 36.24		FBX42_HUMAN (212-366): 7.52e-22: 99.9: 25.00
+	Rn
		70072 B1WBY1_RAT (6-745): 0: 775: 36.24		KLH17_RAT (262-406): 3.24e-18: 88.6: 12.41
+	Rn
		78189 CUL3_RAT (1-745): 0: 769: 26.50		KLH17_RAT (262-406): 3.24e-18: 88.6: 12.41
+	Hs
		1041237 CUL1_HUMAN (6-745): 0: 775: 36.24		KLH13_HUMAN (280-402): 3.05e-13: 73.2: 13.74
+	Hs
		1043271 CUL4A_HUMAN (4-745): 0: 773: 26.86		KLHL9_HUMAN (265-402): 2.48e-13: 73.6: 15.07