HitPredict

Interactor 1: CUL3 (Q13618)
Cullin-3 (CUL-3)
Gene: CUL3

Interactor 2: K2C78 (Q8N1N4)
Keratin, type II cytoskeletal 78 (Cytokeratin-78) (CK-78) (Keratin-5b) (Keratin-78) (K78) (Type-II keratin Kb40)
Gene: KRT78

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.47	0.60	0.536

Property	Details
Experiments	21145461
Identification Methods	affinity chromatography technology, tandem affinity purification
Interaction Type	physical association, association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005829 - cytosol GO:0070062 - extracellular exosome
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 768 Hs			1 520
+	Hs
		729080 CUL3_HUMAN (1-768): 0: 951: 100.00		K22E_HUMAN (83-427): 1.05e-121: 372: 55.65
+	Hs
		409064 CUL3_HUMAN (1-768): 0: 951: 100.00		K2C8_HUMAN (83-465): 4.86e-121: 365: 55.09
+	Hs
		380606 CUL3_HUMAN (1-768): 0: 951: 100.00		K2C1_HUMAN (76-442): 7.29e-112: 347: 56.95
+	Hs
		1042632 CUL3_HUMAN (1-768): 0: 951: 100.00		KRT84_HUMAN (18-510): 1.1e-100: 317: 41.41
+	Hs
		318804 CUL3_HUMAN (1-768): 0: 951: 100.00		K2C75_HUMAN (2-516): 7.92e-95: 300: 48.22
+	Hs
		943669 CUL3_HUMAN (1-768): 0: 951: 100.00		KRT85_HUMAN (3-489): 6.87e-95: 299: 40.77
+	Hs
		1041699 CUL3_HUMAN (1-768): 0: 951: 100.00		K2C71_HUMAN (4-502): 3.35e-87: 279: 48.74
+	Hs
		965423 CUL3_HUMAN (1-768): 0: 951: 100.00		K22O_HUMAN (83-439): 7.09e-84: 274: 61.91
+	Hs
		380472 CUL3_HUMAN (1-768): 0: 951: 100.00		K2C6B_HUMAN (76-448): 4.72e-80: 262: 59.25
+	Hs
		531563 CUL3_HUMAN (1-768): 0: 951: 100.00		K2C5_HUMAN (76-427): 3.19e-78: 258: 62.50
+	Hs
		580129 CUL3_HUMAN (1-768): 0: 951: 100.00		K2C4_HUMAN (6-443): 3.19e-73: 243: 55.10
+	Hs
		280795 CUL3_HUMAN (1-768): 0: 951: 100.00		KRT36_HUMAN (14-424): 2e-68: 228: 23.84
+	Hs
		729081 CUL4A_HUMAN (10-768): 0: 791: 38.32		K22E_HUMAN (83-427): 1.05e-121: 372: 55.65
+	Hs
		380607 CUL4A_HUMAN (10-768): 0: 791: 38.32		K2C1_HUMAN (76-442): 7.29e-112: 347: 56.95
+	Hs
		380608 CUL4B_HUMAN (5-768): 0: 779: 36.77		K2C1_HUMAN (76-442): 7.29e-112: 347: 56.95
+	Hs
		318805 CUL4A_HUMAN (10-768): 0: 791: 38.32		K2C75_HUMAN (2-516): 7.92e-95: 300: 48.22
+	Hs
		943670 CUL4A_HUMAN (10-768): 0: 791: 38.32		KRT85_HUMAN (3-489): 6.87e-95: 299: 40.77
+	Hs
		318806 CUL4B_HUMAN (5-768): 0: 779: 36.77		K2C75_HUMAN (2-516): 7.92e-95: 300: 48.22
+	Hs
		965424 CUL4A_HUMAN (10-768): 0: 791: 38.32		K22O_HUMAN (83-439): 7.09e-84: 274: 61.91
+	Hs
		531564 CUL4B_HUMAN (5-768): 0: 779: 36.77		K2C5_HUMAN (76-427): 3.19e-78: 258: 62.50