HitPredict

Interactor 1: SPTN1 (Q13813)
Spectrin alpha chain, non-erythrocytic 1 (Alpha-II spectrin) (Fodrin alpha chain) (Spectrin, non-erythroid alpha subunit)
Gene: SPTAN1

Interactor 2: SHAN3 (Q9BYB0)
SH3 and multiple ankyrin repeat domains protein 3 (Shank3) (Proline-rich synapse-associated protein 2) (ProSAP2)
Gene: SHANK3

Species: Homo sapiens

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	11509555
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Ank_2~EF-hand_7, Ank_2~SH3_1, SH3_1~SH3_2
Common GO terms	GO:0003779 - actin binding GO:0005829 - cytosol GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2472 Hs			1 1731
+	Mm
		561160 SPTN1_MOUSE (1-2472): 0: 712: 98.42		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Mm
		82760 B9EKJ1_MOUSE (1-2472): 0: 706: 98.18		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Rn
		555260 SPTN1_RAT (1-2472): 0: 713: 98.58		SHAN3_RAT (1-1731): 3.07e-172: 569: 92.31
+	Hs
		862037 SPTN1_HUMAN (1-2472): 0: 714: 100.00		DAPK1_HUMAN (103-579): 1.12e-67: 254: 14.94
+	Hs
		965102 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ANK2_HUMAN (117-358): 6.7e-53: 208: 25.27
+	Mm
		82740 B9EKJ1_MOUSE (1-2472): 0: 706: 98.18		ANK3_MOUSE (120-691): 8.6e-55: 214: 14.98
+	Hs
		1021399 SPTN1_HUMAN (1-2472): 0: 714: 100.00		ANK3_HUMAN (120-561): 2.39e-41: 170: 15.54
+	Hs
		1045573 SPTN1_HUMAN (1-2472): 0: 714: 100.00		SHAN1_HUMAN (320-1726): 3.34e-22: 107: 13.60
+	Mm
		1115949 Q68FG2_MOUSE (141-1932): 3.76e-63: 242: 20.06		SHAN3_MOUSE (1-1731): 8.04e-176: 579: 93.71
+	Mm
		561172 SPTN1_MOUSE (1-2472): 0: 712: 98.42		ANK2_MOUSE (134-336): 2.34e-09: 65.1: 29.56
+	Hs
		360612 SPTA1_HUMAN (1-2472): 2.98e-159: 552: 54.81		ANK1_HUMAN (175-527): 4.16e-38: 159: 17.28
+	Hs
		164586 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		DAPK1_HUMAN (103-579): 1.12e-67: 254: 14.94
+	Hs
		164604 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		ANK2_HUMAN (117-358): 6.7e-53: 208: 25.27
+	Hs
		862027 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		DAPK1_HUMAN (103-579): 1.12e-67: 254: 14.94
+	Hs
		164611 SPTN2_HUMAN (141-1932): 1.25e-65: 250: 20.41		ANK3_HUMAN (120-561): 2.39e-41: 170: 15.54
+	Mm
		103598 Q3UGX2_MOUSE (2-1625): 2.78e-45: 183: 19.60		ANK3_MOUSE (120-691): 8.6e-55: 214: 14.98
+	Rn
		251022 PLEC_RAT (1-1257): 6.84e-37: 156: 10.91		ANK3_RAT (11-639): 1.19e-61: 236: 14.61
+	Hs
		963292 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ANK2_HUMAN (117-358): 6.7e-53: 208: 25.27
+	Hs
		963306 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ANK3_HUMAN (120-561): 2.39e-41: 170: 15.54
+	Hs
		556695 SPTB2_HUMAN (2-1043): 1.4e-42: 174: 20.52		ANK1_HUMAN (175-527): 4.16e-38: 159: 17.28