HitPredict

Interactor 1: NOTC2 (Q04721)
Neurogenic locus notch homolog protein 2 (Notch 2) (hN2) [Cleaved into: Notch 2 extracellular truncation (N2ECD); Notch 2 intracellular domain (N2ICD)]
Gene: NOTCH2

Interactor 2: LAMC2 (Q13753)
Laminin subunit gamma-2 (Cell-scattering factor 140 kDa subunit) (CSF 140 kDa subunit) (Epiligrin subunit gamma) (Kalinin subunit gamma) (Kalinin/nicein/epiligrin 100 kDa subunit) (Ladsin 140 kDa subunit) (Laminin B2t chain) (Laminin-5 subunit gamma) (Large adhesive scatter factor 140 kDa subunit) (Nicein subunit gamma)
Gene: LAMC2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.33	0.60	0.445

Property	Details
Experiments	unassigned3799
Identification Methods	anti tag coimmunoprecipitation
Interaction Type	association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005576 - extracellular region
Homologous interactions	19

Homologous interactions

Color coding for hit scores

	1 2471 Hs			1 1193
+	Hs
		1047781 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		NOTC3_HUMAN (282-743): 1.9e-32: 140: 14.34
+	Hs
		1047538 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		LAMB3_HUMAN (8-188): 2.07e-30: 132: 31.94
+	Hs
		857423 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		NOTC1_HUMAN (328-743): 1.31e-24: 114: 13.60
+	Hs
		183243 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		LAMA5_HUMAN (1-126): 8.17e-11: 69.2: 17.69
+	Hs
		535835 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		LAMC1_HUMAN (69-285): 6.19e-10: 66.1: 17.99
+	Hs
		937387 NOTC2_HUMAN (22-2471): 0: 1400: 100.00		LAMB2_HUMAN (99-284): 5.5e-10: 66.1: 14.77
+	Dm
		68582 A8JNM5_DROME (1600-2294): 1.53e-111: 402: 12.07		NOTCH_DROME (1-568): 1.5e-37: 156: 10.98
+	Dm
		451712 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		NOTCH_DROME (1-568): 1.5e-37: 156: 10.98
+	Dm
		95089 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		E1JHA6_DROME (198-493): 7.25e-11: 69.2: 11.40
+	Dm
		451745 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		LAMA_DROME (3-149): 2.7e-09: 64.2: 20.00
+	Dm
		451968 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		Q9W4Y4_DROME (6-586): 2.37e-09: 64.2: 12.94
+	Dm
		451718 NOTCH_DROME (2-871): 3.92e-108: 390: 32.69		LAMC1_DROME (208-425): 5.09e-09: 63: 11.26
+	Hs
		1331020 ANR44_HUMAN (1522-2009): 3.15e-62: 235: 16.42		NOTC3_HUMAN (282-743): 1.9e-32: 140: 14.34
+	Hs
		1047634 ANR44_HUMAN (1522-2009): 3.15e-62: 235: 16.42		NOTC2_HUMAN (277-743): 3.21e-28: 126: 13.55
+	Hs
		857505 ANR44_HUMAN (1522-2009): 3.15e-62: 235: 16.42		NOTC1_HUMAN (328-743): 1.31e-24: 114: 13.60
+	Hs
		857591 NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26		NOTC3_HUMAN (282-743): 1.9e-32: 140: 14.34
+	Dm
		535775 Q0KIE7_DROME (1917-2288): 7.05e-60: 230: 16.35		LAMB1_DROME (239-501): 3.38e-14: 80: 12.98
+	Hs
		857370 NOTC1_HUMAN (1094-1611): 2.67e-43: 177: 23.26		NOTC1_HUMAN (328-743): 1.31e-24: 114: 13.60
+	Hs
		857407 JAG1_HUMAN (1070-1552): 3.46e-37: 156: 20.04		NOTC1_HUMAN (328-743): 1.31e-24: 114: 13.60