HitPredict

Interactor 1: WRN (Q14191)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
Gene: WRN

Interactor 2: WRN (Q14191)
Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN (DNA helicase, RecQ-like type 3) (RecQ protein-like 2) (Werner syndrome protein) [Includes: 3'-5' exonuclease (EC 3.1.-.-); ATP-dependent helicase (EC 5.6.2.4) (DNA 3'-5' helicase WRN)]
Gene: WRN

Species: Homo sapiens

Source: mint

Category: Small-scale

Confidence: High

Method score Annotation score Interaction score
0.52 1.00 0.724

The method score is based on:

Property Details
Experiments 10783163
Identification Methods pull down, affinity chromatography technology
Interaction Type direct interaction, physical association

The annotation score is based on:

Property Details
Interacting Pfam domains DEAD~DEAD, DEAD~Helicase_C, DEAD~HRDC, DEAD~RecQ_Zn_bind, DNA_pol_A_exo1~DNA_pol_A_exo1, DNA_pol_A_exo1~HRDC, Helicase_C~Helicase_C, HRDC~Helicase_C, Helicase_C~RecQ_Zn_bind, Helicase_C~RQC, HRDC~HRDC, RQC~RecQ_Zn_bind, RQC~RQC
Common GO terms GO:0000287 - magnesium ion binding
GO:0000400 - four-way junction DNA binding
GO:0000403 - Y-form DNA binding
GO:0000405 - bubble DNA binding
GO:0000723 - telomere maintenance
and 54 others

more...
Homologous interactions 15

Homologous interactions

Color coding for hit scores

1 1432
Hs

1 1432
+ Hs
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+ Hs
+ Hs
+ Hs
+ Hs
+ Hs
+ Sp
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+ Hs
+ Hs
+ Hs
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+ At

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Last updated: 15 Jul 2024