HitPredict

Interactor 1: EYA (Q05201)
Protein phosphatase eya (EC 3.1.3.48) (Developmental protein eyes absent) (Protein Clift)
Gene: EYA

Interactor 2: SO (Q27350)
Protein sine oculis
Gene: SO

Species: Drosophila melanogaster

Source: intact

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.90	1.00	0.949

Property	Details
Experiments	15802522, 26980695, 22318629, 16125693, 28619818, 14605208, unassigned4
Identification Methods	affinity chromatography technology, two hybrid, experimental interaction detection
Interaction Type	physical association, direct interaction

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0001744 - insect visual primordium formation GO:0001746 - Bolwig's organ morphogenesis GO:0005634 - nucleus GO:0007283 - spermatogenesis GO:0045944 - positive regulation of transcription by RNA polymerase II and 1 others more... GO:0048749 - compound eye development
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 766 Dm			1 416
+	Dm
		1050774 EYA_DROME (1-766): 0: 571: 100.00		OPTIX_DROME (67-336): 2.74e-50: 178: 42.70
+	Hs
		124662 EYA2_HUMAN (227-766): 6.48e-147: 442: 39.89		SIX4_HUMAN (29-397): 3.03e-71: 240: 36.95
+	Hs
		341699 EYA4_HUMAN (149-766): 1.57e-142: 434: 39.06		SIX4_HUMAN (29-397): 3.03e-71: 240: 36.95
+	Hs
		124604 EYA2_HUMAN (227-766): 6.48e-147: 442: 39.89		SIX1_HUMAN (95-373): 9.61e-70: 223: 61.35
+	Mm
		147613 EYA2_MOUSE (205-766): 5.74e-139: 422: 38.87		SIX4_MOUSE (29-391): 3.81e-71: 240: 38.68
+	Hs
		124654 EYA2_HUMAN (227-766): 6.48e-147: 442: 39.89		SIX2_HUMAN (95-379): 4.11e-67: 217: 58.60
+	Hs
		341573 EYA4_HUMAN (149-766): 1.57e-142: 434: 39.06		SIX1_HUMAN (95-373): 9.61e-70: 223: 61.35
+	Hs
		341684 EYA4_HUMAN (149-766): 1.57e-142: 434: 39.06		SIX2_HUMAN (95-379): 4.11e-67: 217: 58.60
+	Hs
		97045 E9PLN6_HUMAN (171-766): 1.34e-138: 424: 39.32		SIX1_HUMAN (95-373): 9.61e-70: 223: 61.35
+	Mm
		1223916 EYA4_MOUSE (171-766): 5.63e-138: 422: 40.13		SIX1_MOUSE (95-373): 1.95e-69: 222: 61.35
+	Hs
		97046 E9PLN6_HUMAN (171-766): 1.34e-138: 424: 39.32		SIX2_HUMAN (95-379): 4.11e-67: 217: 58.60
+	Hs
		1405004 EYA1_HUMAN (231-766): 7.76e-124: 385: 40.36		SIX4_HUMAN (29-397): 3.03e-71: 240: 36.95
+	Mm
		1021847 EYA1_MOUSE (223-766): 5.14e-123: 382: 39.68		SIX4_MOUSE (29-391): 3.81e-71: 240: 38.68
+	Hs
		341621 EYA4_HUMAN (149-766): 1.57e-142: 434: 39.06		SIX5_HUMAN (81-414): 6.74e-51: 184: 40.06
+	Hs
		1149418 EYA1_HUMAN (231-766): 7.76e-124: 385: 40.36		SIX1_HUMAN (95-373): 9.61e-70: 223: 61.35
+	Mm
		1021540 EYA3_MOUSE (267-766): 8.98e-125: 384: 37.11		SIX1_MOUSE (95-373): 1.95e-69: 222: 61.35
+	Hs
		1405003 EYA1_HUMAN (231-766): 7.76e-124: 385: 40.36		SIX2_HUMAN (95-379): 4.11e-67: 217: 58.60
+	Mm
		999800 EYA3_MOUSE (267-766): 8.98e-125: 384: 37.11		SIX5_MOUSE (96-414): 7.7e-52: 186: 40.87
+	Hs
		1323268 EYA1_HUMAN (231-766): 7.76e-124: 385: 40.36		SIX5_HUMAN (81-414): 6.74e-51: 184: 40.06
+	Mm
		999801 EYA1_MOUSE (223-766): 5.14e-123: 382: 39.68		SIX5_MOUSE (96-414): 7.7e-52: 186: 40.87