HitPredict

Interactor 1: SIX1 (Q62231)
Homeobox protein SIX1 (Sine oculis homeobox homolog 1)
Gene: SIX1

Interactor 2: EYA4 (Q9Z191)
Protein phosphatase EYA4 (EC 3.1.3.48) (Eyes absent homolog 4)
Gene: EYA4

Species: Mus musculus

Source: biogrid

Category: Small-scale

Confidence: High

Method score	Annotation score	Interaction score
0.38	1.00	0.621

Property	Details
Experiments	15492887
Identification Methods	two hybrid
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	Hydrolase~SIX1_SD
Common GO terms	GO:0005634 - nucleus GO:0005737 - cytoplasm GO:0007605 - sensory perception of sound GO:0042474 - middle ear morphogenesis
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 284 Mm			1 616
+	Hs
		97045 SIX1_HUMAN (1-284): 4.65e-98: 290: 99.30		E9PLN6_HUMAN (1-616): 0: 719: 96.59
+	Hs
		341573 SIX1_HUMAN (1-284): 4.65e-98: 290: 99.30		EYA4_HUMAN (1-616): 0: 713: 90.45
+	Hs
		97046 SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48		E9PLN6_HUMAN (1-616): 0: 719: 96.59
+	Hs
		341684 SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48		EYA4_HUMAN (1-616): 0: 713: 90.45
+	Hs
		341699 SIX4_HUMAN (5-282): 3.99e-75: 245: 50.36		EYA4_HUMAN (1-616): 0: 713: 90.45
+	Hs
		1149418 SIX1_HUMAN (1-284): 4.65e-98: 290: 99.30		EYA1_HUMAN (30-616): 0: 609: 69.95
+	Mm
		1021848 SIX1_MOUSE (1-284): 2.91e-97: 289: 100.00		EYA1_MOUSE (30-616): 0: 607: 69.90
+	Hs
		124604 SIX1_HUMAN (1-284): 4.65e-98: 290: 99.30		EYA2_HUMAN (72-616): 0: 603: 54.97
+	Mm
		1021849 SIX2_MOUSE (1-284): 1.69e-90: 272: 73.06		EYA1_MOUSE (30-616): 0: 607: 69.90
+	Hs
		1405003 SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48		EYA1_HUMAN (30-616): 0: 609: 69.95
+	Hs
		124654 SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48		EYA2_HUMAN (72-616): 0: 603: 54.97
+	Hs
		1405004 SIX4_HUMAN (5-282): 3.99e-75: 245: 50.36		EYA1_HUMAN (30-616): 0: 609: 69.95
+	Mm
		1021847 SIX4_MOUSE (5-273): 1.6e-74: 244: 50.56		EYA1_MOUSE (30-616): 0: 607: 69.90
+	Hs
		124662 SIX4_HUMAN (5-282): 3.99e-75: 245: 50.36		EYA2_HUMAN (72-616): 0: 603: 54.97
+	Hs
		1405016 SIX2_HUMAN (1-284): 2.69e-89: 269: 71.48		EYA3_HUMAN (66-616): 0: 576: 53.83
+	Mm
		1021540 SIX1_MOUSE (1-284): 2.91e-97: 289: 100.00		EYA3_MOUSE (69-616): 0: 555: 51.17
+	Mm
		147613 SIX4_MOUSE (5-273): 1.6e-74: 244: 50.56		EYA2_MOUSE (72-616): 0: 587: 55.44
+	Mm
		1021850 SIX3_MOUSE (1-249): 1.02e-68: 217: 55.73		EYA1_MOUSE (30-616): 0: 607: 69.90
+	Dm
		1050766 SO_DROME (2-269): 7.66e-79: 246: 62.69		EYA_DROME (145-616): 3.51e-159: 476: 46.26
+	Ce
		196357 HM33_CAEEL (6-254): 5.53e-65: 205: 47.39		EYA1_CAEEL (144-612): 2.36e-109: 339: 23.72