HitPredict

Interactor 1: SCN5A (Q14524)
Sodium channel protein type 5 subunit alpha (Sodium channel protein cardiac muscle subunit alpha) (Sodium channel protein type V subunit alpha) (Voltage-gated sodium channel subunit alpha Nav1.5) (hH1)
Gene: SCN5A

Interactor 2: SMUF2 (Q9HAU4)
E3 ubiquitin-protein ligase SMURF2 (hSMURF2) (EC 2.3.2.26) (HECT-type E3 ubiquitin transferase SMURF2) (SMAD ubiquitination regulatory factor 2) (SMAD-specific E3 ubiquitin-protein ligase 2)
Gene: SMURF2

Species: Homo sapiens

Source: intact

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.41	0.60	0.501

Property	Details
Experiments	unassigned3713
Identification Methods	phage display
Interaction Type	direct interaction

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005654 - nucleoplasm GO:0005886 - plasma membrane
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 2016 Hs			1 748
+	Mm
		808378 SCN5A_MOUSE (1-2016): 0: 2002: 94.35		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Hs
		1079738 SCN9A_HUMAN (2-2000): 0: 1826: 59.45		SMUF2_HUMAN (1-748): 0: 834: 100.00
+	Hs
		723851 SCN1A_HUMAN (3-2000): 0: 1819: 60.28		SMUF2_HUMAN (1-748): 0: 834: 100.00
+	Hs
		808128 SCN5A_HUMAN (1-2016): 0: 2020: 100.00		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Mm
		93283 SCN5A_MOUSE (1-2016): 0: 2002: 94.35		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Mm
		69867 SCN2A_MOUSE (3-2000): 0: 1857: 61.30		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		808358 SCN9A_MOUSE (2-2000): 0: 1831: 59.82		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		808363 SCNAA_MOUSE (5-2003): 0: 1830: 60.31		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		69865 SCN2A_MOUSE (3-2000): 0: 1857: 61.30		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Mm
		93274 SCN9A_MOUSE (2-2000): 0: 1831: 59.82		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Mm
		93276 SCNAA_MOUSE (5-2003): 0: 1830: 60.31		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Hs
		723839 SCN1A_HUMAN (3-2000): 0: 1819: 60.28		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Mm
		808381 SCN8A_MOUSE (2-2000): 0: 1737: 59.92		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Hs
		808340 SCNAA_HUMAN (5-2004): 0: 1774: 61.55		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Mm
		93284 SCN8A_MOUSE (2-2000): 0: 1737: 59.92		E9PXB7_MOUSE (85-746): 0: 636: 39.39
+	Hs
		808322 SCN8A_HUMAN (2-2000): 0: 1730: 59.39		NEDD4_HUMAN (104-746): 0: 628: 38.73
+	Hs
		1055040 SCN5A_HUMAN (1-2016): 0: 2020: 100.00		NED4L_HUMAN (5-396): 1.96e-36: 149: 18.58
+	Hs
		125457 SCN5A_HUMAN (1-2016): 0: 2020: 100.00		WWP2_HUMAN (1-416): 7.64e-26: 116: 17.39
+	Mm
		808349 Q3UF73_MOUSE (4-204): 1.61e-85: 280: 67.16		NEDD4_MOUSE (14-746): 0: 692: 34.57
+	Mm
		93270 Q3UF73_MOUSE (4-204): 1.61e-85: 280: 67.16		E9PXB7_MOUSE (85-746): 0: 636: 39.39