Protein: TIF1B
Transcription intermediary factor 1-beta (TIF1-beta) (E3 SUMO-protein ligase TRIM28) (EC 2.3.2.27) (KRAB-A-interacting protein) (KRIP-1) (RING-type E3 ubiquitin transferase TIF1-beta) (Tripartite motif-containing protein 28)

Gene: TIF1B, Trim28
Organism: Mus musculus
Interactions: 81
UniProt ID: Q62318

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000791 - euchromatin
GO:0000792 - heterochromatin
GO:0001701 - in utero embryonic development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1014253

CBX1
Chromobox protein homolog 1

5

20

Small-scale

0.936

High

1223213

CBX5
Chromobox protein homolog 5

5

20

Small-scale

0.925

High

1224077

Q9DCC5
Cbx3 protein

4

20

Small-scale

0.913

High

1224048

TIF1B
Transcription intermediary factor 1-beta

2

19

Small-scale

0.768

High

1224057

NANOG
Homeobox protein NANOG

3

20

Small-scale

0.662

High

852344

CBP
Histone lysine acetyltransferase CREBBP

1

19

Small-scale

0.646

High

1189443

SMCA4
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 4

1

16

Small-scale

0.646

High

1221289

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

17

Small-scale

0.646

High

1224050

TIF1A
Transcription intermediary factor 1-alpha

1

19

Small-scale

0.646

High

1224072

ROAA
Heterogeneous nuclear ribonucleoprotein A/B

1

19

Small-scale

0.646

High

1224073

TRI33
E3 ubiquitin-protein ligase TRIM33

1

19

Small-scale

0.646

High

1224085

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

7

Small-scale

0.646

High

1224053

UHRF2
E3 ubiquitin-protein ligase UHRF2

1

20

Small-scale

0.618

High

205208

DAXX
Death domain-associated protein 6

2

5

Small-scale

0.594

High

609540

PCNA
Proliferating cell nuclear antigen

2

3

Small-scale

0.584

High

1224082

AIRE
Autoimmune regulator

1

20

Small-scale

0.575

High

1021126

MCM6
DNA replication licensing factor MCM6

1

18

High-throughput

0.561

High

1224080

SRTD1
SERTA domain-containing protein 1

1

2

Small-scale

0.552

High

629300

PO5F1
POU domain, class 5, transcription factor 1

1

15

Small-scale

0.536

High

1013599

TNIK
Traf2 and NCK-interacting protein kinase

1

13

High-throughput

0.536

High

1193758

SHAN3
SH3 and multiple ankyrin repeat domains protein 3

1

6

High-throughput

0.536

High

1222769

SMRD1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1

1

2

Small-scale

0.536

High

1223021

FXR1
RNA-binding protein FXR1

1

16

High-throughput

0.536

High

1224054

MYCB2
E3 ubiquitin-protein ligase MYCBP2

1

2

High-throughput

0.536

High

1224056

MYOME
Myomegalin

1

20

High-throughput

0.536

High

1224078

TSC1
Hamartin

1

16

High-throughput

0.536

High

449638

MYB
Transcriptional activator Myb

1

6

Small-scale

0.527

High

927806

ATX1
Ataxin-1

1

3

High-throughput

0.515

High

1224081

CAF1A
Chromatin assembly factor 1 subunit A

1

13

Small-scale

0.501

High

236755

PER2
Period circadian protein homolog 2

1

17

Small-scale

0.500

High

555577

NR4A1
Nuclear receptor subfamily 4 group A member 1

1

20

Small-scale

0.500

High

846712

MSH2
DNA mismatch repair protein Msh2

1

5

Small-scale

0.500

High

1021781

SMRC1
SWI/SNF complex subunit SMARCC1

1

13

Small-scale

0.500

High

1191316

Q3V232
Zinc finger protein 709

1

20

Small-scale

0.500

High

1221381

ITF2
Transcription factor 4

1

6

Small-scale

0.500

High

1224074

VTA1
Vacuolar protein sorting-associated protein VTA1 homolog

1

2

Small-scale

0.500

High

1224083

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

3

Small-scale

0.500

High

1223300

Z354A
Zinc finger protein 354A

1

20

High-throughput

0.481

High

1224059

ZNF2
Zinc finger protein 2

1

20

High-throughput

0.481

High

1224076

Q9D4A7
Zinc finger protein 819

1

20

Small-scale

0.481

High

205434

SOCS1
Suppressor of cytokine signaling 1

1

17

Small-scale

0.479

High

236903

ACK1
Activated CDC42 kinase 1

1

19

Small-scale

0.479

High

646751

ZFP42
Zinc finger protein 42

1

20

Small-scale

0.479

High

873002

SOX2
Transcription factor SOX-2

1

20

High-throughput

0.479

High

876530

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C]

1

20

Small-scale

0.479

High

947438

LMBL2
Lethal(3)malignant brain tumor-like protein 2

1

3

Small-scale

0.479

High

966018

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

20

High-throughput

0.479

High

972236

1433E
14-3-3 protein epsilon

1

3

High-throughput

0.479

High

1047375

SMRCD
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1

1

17

Small-scale

0.479

High

1211240

Q5SXC4
Vascular endothelial zinc finger 1

1

20

Small-scale

0.479

High

1222237

NR0B1
Nuclear receptor subfamily 0 group B member 1

1

20

Small-scale

0.479

High

1222776

SOX17
Transcription factor SOX-17

1

20

Small-scale

0.479

High

1224049

TFE3
Transcription factor E3

1

7

High-throughput

0.479

High

1224055

FACD2
Fanconi anemia group D2 protein homolog

1

6

High-throughput

0.479

High

1224058

BACD1
BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 1

1

13

High-throughput

0.479

High

1224060

Q8BLK6
Zinc finger protein 68

1

20

Small-scale

0.479

High

1224061

TF3C4
General transcription factor 3C polypeptide 4

1

3

Small-scale

0.479

High

1224067

KAT5
Histone acetyltransferase KAT5

1

5

Small-scale

0.479

High

1224068

LN28A
Protein lin-28 homolog A

1

12

Small-scale

0.479

High

1224070

NLRP3
NACHT, LRR and PYD domains-containing protein 3

1

8

Small-scale

0.479

High

1224071

EED
Polycomb protein EED

1

20

High-throughput

0.479

High

1224075

SSBP3
Single-stranded DNA-binding protein 3

1

8

Small-scale

0.479

High

1224084

Q9Z117
KRAB-containing zinc-finger protein KRAZ1

1

20

Small-scale

0.479

High

1201670

LITD1
LINE-1 type transposase domain-containing protein 1

1

2

Small-scale

0.457

High

108327

ZN809
Zinc finger protein 809

1

20

Small-scale

0.445

High

777910

FMR1
Fragile X messenger ribonucleoprotein 1

1

16

High-throughput

0.445

High

1000134

TBX5
T-box transcription factor TBX5

1

8

Small-scale

0.445

High

1224051

Q6AXH7
Histone-lysine N-methyltransferase EZH2

1

20

High-throughput

0.445

High

1224066

FTM
Protein fantom

1

17

High-throughput

0.445

High

1224079

XPO7
Exportin-7

1

7

High-throughput

0.445

High

398481

CFAD
Complement factor D

1

1

High-throughput

0.437

High

663108

GRIA2
Glutamate receptor 2

1

1

High-throughput

0.437

High

946650

PIM3
Serine/threonine-protein kinase pim-3

1

11

Small-scale

0.437

High

1224052

TEDC2
Tubulin epsilon and delta complex protein 2

1

1

High-throughput

0.437

High

1224062

IQCB1
IQ calmodulin-binding motif-containing protein 1

1

1

High-throughput

0.437

High

1224063

Q8BPK8
Fragile X messenger ribonucleoprotein 1

1

16

High-throughput

0.437

High

1224064

A16L1
Autophagy-related protein 16-1

1

20

High-throughput

0.437

High

1224065

MT21E
Protein-lysine methyltransferase METTL21E

1

4

High-throughput

0.437

High

148233

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

4

High-throughput

0.407

High

1224069

FNDC5
Fibronectin type III domain-containing protein 5

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025