Interactor 1: KRAF1 (Q07292)
Raf homolog serine/threonine-protein kinase (EC 2.7.11.1) (Abnormal cell lineage protein 45)
Gene: lin-45
Interactor 2: MEK2 (Q10664)
Dual specificity mitogen-activated protein kinase kinase mek-2 (MAP kinase kinase mek-2) (EC 2.7.12.2)
Gene: mek-2
Species: Caenorhabditis elegans
Source: intact
Category: High-throughput
Confidence: High
| Method score | Annotation score | Interaction score |
|---|---|---|
| 0.67 | 1.00 | 0.820 |
The method score is based on:
| Property | Details |
|---|---|
| Experiments | 12679813, 18692475, unassigned701 |
| Identification Methods | two hybrid |
| Interaction Type | direct interaction, physical association |
The annotation score is based on:
| Property | Details |
|---|---|
| Interacting Pfam domains | C1_1~Pkinase, PK_Tyr_Ser-Thr~Pkinase |
| Common GO terms | GO:0000165 - MAPK cascade GO:0005524 - ATP binding GO:0007265 - Ras protein signal transduction GO:0040025 - vulval development GO:0048477 - oogenesis and 3 others more... |
| Homologous interactions | 20 |
Homologous interactions (Top 20)
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Service provided by Combinatics, Japan
Last updated: 11Aug2025
